Bringing together leading clinicians and scientists, as well as trainees, this live and virtual half day event will provide a comprehensive overview of the latest in treatment and clinical, basic, and translational research throughout UCSF in the area of central nervous system metastatic disease. There is no cost for this program, but registration is required and CME credits are not available.
Lunch will be served following the event, and we encourage participants to come with questions and ideas for future direction and collaborations.
Registration link: https://ucsf.co1.qualtrics.com/jfe/preview/SV_cIaXdmPpk5KjtHw?Q_CHL=preview&Q_SurveyVersionID=current
In-person location: Fisher West Banquet Hall in the Mission Bay Conference Center (1675 Owens Street, San Francisco, CA 94158)
Program
8:00-8:10 AM Opening Remarks: John de Groot, MD
- CLINICAL PERSPECTIVES IN THE MANAGEMENT OF CNS METASTATIC DISEASE
Introduction by: Mariza Daras, MD
8:15–8:30 AM Adil Daud, MD
Clinical Professor of Medicine, Division of Hematology Oncology
Mechanisms of PD1 resistance in melanoma and the combinatorial approach to therapies: quadruple checkpoint blockade
8:30–8:45 AM Mariza Daras, MD
Associate Professor, Division of Neuro-oncology
Overcoming the blood brain barrier in the management of CNS metastases
8:45–9:00 AM Steve Braunstein, MD, PhD
Associate Professor, Department of Radiation Oncology
The role of brachytherapy in recurrent CNS metastases
9:00–9:15 AM Manish Aghi, MD, PhD
Professor, Department of Neurological Surgery
Laser interstitial thermal therapy in management of RT necrosis and treatment refractory brain metastases
9:15–9:30 AM Javier Villanueva-Meyer, MD
Assistant Professor, Department of Clinical Radiology
Advanced Imaging in the early detection of brain metastases and in differentiating progression from treatment-related inflammation
9:30–9:40 AM Questions/Discussion
- PRECLINCAL AND TRANSLATIONAL EFFORTS
Introduction by: Michelle Melisko, MD
9:45–10:05 AM Hugo Gonzalez Velozo, PhD
Postdoctoral Scholar, Department of Anatomy
Cell Archetypes in Human Brain Metastases: Connecting Tumor Cell Programs, and Tumor Microenvironment
10:05–10:25 AM Laura Huppert, MD
Assistant Clinical Professor, Division of Hematology Oncology
Chris Im, PhD
Postdoctoral Scholar, Department of Pathology
CSF Immune profiling in leptomeningeal disease
10:25–10:45 AM Harish Vasudevan, MD, PhD
Assistant Professor, Department of Radiation Oncology
Mutational analysis and single cell sequencing of melanoma brain metastases
10:45–11:05 AM Joanna Phillips, MD, PhD
Professor, Departments of Neurological Surgery and Pathology
Co-director of the UCSF Brain Tumor SPORE Biorepository
CNS metastasis biobanking: a critical resource in translational efforts
11:05–11:15 AM Questions/Discussion
- TRAINEE ABSTRACTS
Introduction by: Steve Braunstein, MD, PhD
11:20–11:30 AM Oral Presentation 1 – Ramin Morshed, MD (Dept of Neurosurgery)
Supervised machine learning identifies risk factors associated with leptomeningeal disease after surgical resection of brain metastases
11:30–11:40 AM Oral Presentation 2 – Lisa Ni, MD (Dept of Radiation Oncology)
Volumetric Response of Brain Metastases in EGFR mutant NSCLC treated with Osimertinib alone vs in combination with RT
11:40–11:50 AM Oral Presentation 3 – William Chen, MD (Dept of Radiation Oncology)
Radiosurgery in eloquent areas: efficacy and safety of stereotactic radiosurgery for brainstem metastases
11:50 AM–12:00 PM Closing Remarks: Mariza Daras, MD - The UCSF CNS Metastasis Experience: Future areas of growth and opportunity
12:00 PM Lunch and Discussion on Future Efforts/Collaborations
Symposium Organizers
