Geoffrey T. Manley MD, PhD
Associate Professor in Residence of Neurological Surgery
Co-Director and Principal Investigator, Brain and Spinal Injury Center (BASIC)
Chief of Neurotrauma, San Francisco General Hospital
Geoffrey T. Manley, MD, PhD is the Chief of Neurosurgery at San Francisco General Hospital and Professor of Neurosurgery at the University of California San Francisco (UCSF). He is a trauma neurosurgeon with clinical interests in brain injury, spinal cord injury and neurocritical critical care. His translational research interests span from the laboratory to the bedside.
Dr. Manley is a graduate of the Medical Scientist Training Program at Cornell University Medical College, where he earned his medical degree as well as his doctorate degree in Neuroscience. He completed his residency in Neurosurgery at UCSF and a Postdoctoral Fellowship in Molecular Biophysics. Dr. Manley is also a faculty member of the California Institute for Quantitative Biosciences and the UCSF Center for Clinical and Translational Informatics.
Dr. Manley is an internationally recognized expert in neurotrauma. He has published over 120 manuscripts that reflect a wide range of research interests from molecular aspects of brain injury to the clinical care of head trauma patients. He has helped to define new molecular mechanisms of injury to the nervous system that may lead to new treatments for these devastating injuries. He is also considered a leader in the rapidly growing field of advanced neuromonitoring and clinical informatics for critical care. His many honors include the General Motors Trauma Research Award and the Trauma Research Award from the American College of Surgeons. He has served as a Consultant for the Prehospital Guidelines Committee for the World Health Organization and on a number of committees for the National Institutes of Health.
Education, Training, and Previous Positions
- 1988: BS, University of Kentucky, Lexington
1994: PhD, Cornell University Graduate School of Medical Sciences
1994-1995: Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center, Laboratory of Molecular Neuro-Oncology
1995: MD, Cornell University Medical College
1995-1996: Internship in General Surgery, UCSF
1996-2001: Residency in Neurological Surgery, UCSF
1998-1999: Postdoctoral Fellow: UCSF Cardiovascular Research Institute, Laboratory of Molecular Biophysics
Selected Professional Memberships and Appointments
- American Association for the Advancement of Science
American Association of Neurological Surgeons
American Federation for Clinical Research
American Medical Association
Brain Edema Society
California Association of Neurological Surgeons
Congress of Neurological Surgeons
International Society of Oxygen Transport to Tissue
Joint Council of State Neurosurgical Societies
Neurotrauma Society
Selected Honors and Awards
- 1996: Most Valuable Intern Award, San Francisco General Hospital
1997: Housestaff Award for Excellence in Teaching , UCSF
1997: Northern California Committee on Trauma Resident Award
1997: First Place, Residents Trauma Research Competition, Western Regional Committee on Trauma
1998: General Motors Trauma Research Award
1998: First Place, 20th Annual Resident's Trauma Paper Competition, American College of Surgeons, Committee on Trauma
1998: Earl Young Award, Western Trauma Association
1999: First Place, Prehospital Research Competition , Prehospital Research Forum
2000: Neurotrauma Resident Award for Brain Injury Research, American Association of Neurological Surgeons
2006: Heroes & Hearts Award, San Francisco General Hospital Foundation
Selected Recent Publications
Wan JJ, Cohen MJ, Rosenthal G, Haitsma IK, Morabito DJ, Derugin N, Knudson MM, Manley GT. Refining resuscitation strategies using tissue oxygen and perfusion monitoring in critical organ beds. J Trauma 2009;66(2):353-7.
Sparrey CJ, Manley GT, Keaveny TM. Effects of White, Grey, and Pia Mater Properties on Tissue Level Stresses and Strains in the Compressed Spinal Cord. J Neurotrauma 2009; [Epub ahead of Print]. Stiver SI, Gean AD, Manley GT. Survival with good outcome after cerebral herniation and Duret hemorrhage caused by traumatic brain injury. J Neurosurg 2008; [Epub Ahead of Print].
Yuh EL, Gean AD, Manley GT, Callen AL, Wintermark M. Computer-aided assessment of head computed tomography (CT) studies in patients with suspected traumatic brain injury. J Neurotrauma 2008;5(10):1163-72.
Manley GT. Biaxial Response of Passive Human Cerebral Arteries. Ann Biomed Eng 2008;36(12):2028-41.
Stiver SI, Manley GT. Prehospital management of traumatic brain injury. Neurosurg Focus 2008;25(4):E5.
Vik A, Nag T, Fredriksli OA, Skandsen T, Moen KG, Schirmer-Mikalsen K, Manley GT. Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injury. J Neurosurg 2008;109(4):678-84.
Lee H, Wintermark M, Gean AD, Ghajar J, Manley GT, Mukherjee P. Focal Lesions in Acute Mild Traumatic Brain Injury and Neurocognitive Outcome: CT Versus 3T MRI. J Neurotrauma. 2008;25(9):1049-56.
Stiver SI, Wintermark M, Manley GT. Reversible monoparesis following decompressive hemicraniectomy for traumatic brain injury. J Neurosurg 2008;109(2):245-54.
Saatman KE, Duhaime AC, Bullock R, Maas AI, Valadka A, Manley GT; Workshop Scientific Team and Advisory Panel Members. Classification of traumatic brain injury for targeted therapies. J Neurotrauma 2008;25(7):719-38.
Rosenthal G, Hemphill JC 3rd, Sorani M, Martin C, Morabito D, Obrist WD, Manley GT. Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Crit Care Med 2008;36(6):1917-24.
Sorani MD, Morabito D, Rosenthal G, Giacomini KM, Manley GT. Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system. J Neurotrauma 2008;25(4):291-8.
Niogi SN, Mukherjee P, Ghajar J, Johnson C, Kolster RA, Sarkar R, Lee H, Meeker M, Zimmerman RD, Manley GT, McCandliss BD. Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury. AJNR Am J Neuroradiol 2008;29(5):967-73.
Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma 2007;63(6):1254-62.
Sorani MD, Manley GT. Dose-response relationship of mannitol and intracranial pressure: a metaanalysis. J Neurosurg 2008;108(1):80-7.
Rosenthal G, Hemphill JC, Sorani M, Martin C, Morabito D, Meeker M, Wang V, Manley GT. The role of lung function in brain tissue oxygenation following traumatic brain injury. J Neurosurg 2008;108(1):59-65.
Zador Z, Magzoub M, Jin S, Manley GT, Papadopoulos MC, Verkman AS. Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain. FASEB J 2008;22:870-879.
Sorani MD, Manley GT. Dose-response relationship of mannitol and intracranial pressure: a metaanalysis. J Neurosurg 2008;108(1):80-7.
Rosenthal G, Hemphill JC, Sorani M, Martin C, Morabito D, Meeker M, Wang V, Manley GT. The role of lung function in brain tissue oxygenation following traumatic brain injury. J Neurosurg 2008;108(1):59-65.
Smith JS, Chang EF, Rosenthal G, Meeker M, von Koch C, Manley GT, Holland MC. The role of early follow-up computed tomography imaging in the management of traumatic brain injury patients with intracranial hemorrhage. J Trauma 2007;63(1):75-82.
Zador Z, Bloch O, Yao X, Manley GT. Aquaporins: role in cerebral edema and brain water balance [Review]. Prog Brain Res 2007;161:185-94.
Sorani MD, Hemphill JC 3rd, Morabito D, Rosenthal G, Manley GT. New approaches to physiological informatics in neurocritical care. Neurocrit Care 2007;7(1):45-52.
Quiñones-Hinojosa A, Chi JH, Manley GT. Emergent placement of halo orthosis after a traumatic cervical injury leading to a cerebral abscess. J Trauma 2007;62(6):E11-3.
Auguste KI, Jin S, Uchida K, Yan D, Manley GT, Papadopoulos MC, Verkman AS. Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury. FASEB J 2007;21(1):108-16.
Chi JH, Knudson MM, Vassar MJ, McCarthy MC, Shapiro MB, Mallet S, Holcroft JJ, Moncrief H, Noble J, Wisner D, Kaups KL, Bennick LD, Manley GT. Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study. J Trauma 2006;61(5):1134-41.
Ikossi DG, Knudson MM, Morabito DJ, Cohen MJ, Wan JJ, Khaw L, Stewart CJ, Hemphill C, Manley GT. Continuous muscle tissue oxygenation in critically injured patients: a prospective observational study. J Trauma 2006;61(4):780-90.
Zaharchuk G, Busse RF, Rosenthal G, Manley GT, Glenn OA, Dillon WP. Noninvasive oxygen partial pressure measurement of human body fluids in vivo using magnetic resonance imaging. Acad Radiol 2006;13(8):1016-24.
Manley GT, Rosenthal G, Lam M, Morabito D, Yan D, Derugin N, Bollen A, Knudson MM, Panter SS. Controlled cortical impact in swine: pathophysiology and biomechanics. J Neurotrauma 2006;23(2):128-39.
Livingston DH, Lavery RF, Mosenthal AC, Knudson MM, Lee S, Morabito D, Manley GT, Nathens A, Jurkovich G, Hoyt DB, Coimbra R. Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial. J Trauma 2005;59(6):1298-304.
Zador Z, Magzoub M, Jin S, Manley GT, Papadopoulos MC, Verkman AS. Barton CW, Hemphill JC, Morabito D, Manley G. A novel method of evaluating the impact of secondary brain insults on functional outcomes in traumatic brain-injured patients. Acad Emerg Med 2005;12(1):1-6.
Hemphill JC 3rd, Barton CW, Morabito D, Manley GT. Influence of data resolution and interpolation method on assessment of secondary brain insults in neurocritical care. Physiol Meas 2005;26(4):373-86.
Hemphill JC 3rd, Smith WS, Sonne DC, Morabito D, Manley GT. Relationship between brain tissue oxygen tension and CT perfusion: feasibility and initial results. AJNR Am J Neuroradiol 2005;26(5):1095-100.
Le TH, Mukherjee P, Henry RG, Berman JI, Ware M, Manley GT. Diffusion tensor imaging with three-dimensional fiber tractography of traumatic axonal shearing injury: an imaging correlate for the posterior callosal "disconnection" syndrome: case report. Neurosurgery 2005;56(1):189.
Meeker M, Du R, Bacchetti P, Privitera CM, Larson MD, Holland MC, Manley G. Pupil examination: validity and clinical utility of an automated pupillometer. J Neurosci Nurs 2005;37(1):34-40.
Monson KL, Goldsmith W, Barbaro NM, Manley GT. Significance of source and size in the mechanical response of human cerebral blood vessels. J Biomech 2005;38(4):737-44.
Oshio K, Binder DK, Liang Y, Bollen A, Feuerstein B, Berger MS, Manley GT. Expression of the aquaporin-1 water channel in human glial tumors. Neurosurgery 2005;56(2):375-81; discussion 375-81.
Oshio K, Watanabe H, Song Y, Verkman AS, Manley GT. Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J 2005;19(1):76-8.
Zaharchuk G, Martin AJ, Rosenthal G, Manley GT, Dillon WP. Measurement of cerebrospinal fluid oxygen partial pressure in humans using MRI. Magn Reson Med 2005;54(1):113-21.