Geoffrey T. Manley MD, PhD


Professor in Residence and Vice Chairman of Neurological Surgery

Co-Director and Principal Investigator, Brain and Spinal Injury Center (BASIC)

Chief of Neurosurgery, San Francisco General Hospital

Geoffrey T. Manley, MD, PhD is the Chief of Neurosurgery at San Francisco General Hospital and Professor of Neurosurgery at the University of California San Francisco (UCSF). He is a trauma neurosurgeon with clinical interests in brain injury, spinal cord injury and neurocritical critical care. His translational research interests span from the laboratory to the bedside.

Dr. Manley is a graduate of the Medical Scientist Training Program at Cornell University Medical College, where he earned his medical degree as well as his doctorate degree in Neuroscience. He completed his residency in Neurosurgery at UCSF and a Postdoctoral Fellowship in Molecular Biophysics. Dr. Manley is also a faculty member of the California Institute for Quantitative Biosciences and the UCSF Center for Clinical and Translational Informatics.

Dr. Manley is an internationally recognized expert in neurotrauma. He has published over 120 manuscripts that reflect a wide range of research interests from molecular aspects of brain injury to the clinical care of head trauma patients. He has helped to define new molecular mechanisms of injury to the nervous system that may lead to new treatments for these devastating injuries. He is also considered a leader in the rapidly growing field of advanced neuromonitoring and clinical informatics for critical care. His many honors include the General Motors Trauma Research Award and the Trauma Research Award from the American College of Surgeons. He has served as a Consultant for the Prehospital Guidelines Committee for the World Health Organization and on a number of committees for the National Institutes of Health.

Education, Training, and Previous Positions

1988: BS, University of Kentucky, Lexington
1994: PhD, Cornell University Graduate School of Medical Sciences
1994-1995: Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center, Laboratory of Molecular Neuro-Oncology
1995: MD, Cornell University Medical College
1995-1996: Internship in General Surgery, UCSF
1996-2001: Residency in Neurological Surgery, UCSF
1998-1999: Postdoctoral Fellow: UCSF Cardiovascular Research Institute, Laboratory of Molecular Biophysics

Selected Professional Memberships and Appointments

American Association for the Advancement of Science
American Association of Neurological Surgeons
American Federation for Clinical Research
American Medical Association
Brain Edema Society
California Association of Neurological Surgeons
Congress of Neurological Surgeons
International Society of Oxygen Transport to Tissue
Joint Council of State Neurosurgical Societies
Neurotrauma Society

Selected Honors and Awards

1996: Most Valuable Intern Award, San Francisco General Hospital
1997: Housestaff Award for Excellence in Teaching , UCSF
1997: Northern California Committee on Trauma Resident Award
1997: First Place, Residents Trauma Research Competition, Western Regional Committee on Trauma
1998: General Motors Trauma Research Award
1998: First Place, 20th Annual Resident's Trauma Paper Competition, American College of Surgeons, Committee on Trauma
1998: Earl Young Award, Western Trauma Association
1999: First Place, Prehospital Research Competition , Prehospital Research Forum
2000: Neurotrauma Resident Award for Brain Injury Research, American Association of Neurological Surgeons
2006: Heroes & Hearts Award, San Francisco General Hospital Foundation

Selected Recent Publications

Laroche M, Kutcher ME, Huang MC, Cohen MJ, Manley GT. Coagulopathy after traumatic brain injury. Neurosurgery 2012;70(6):1334-45.

Yuh EL, Cooper SR, Ferguson AR, Manley GT. Quantitative CT improves outcome prediction in acute traumatic brain injury. J Neurotrauma 2012;29(5):735-46.

Lu DC, Zador Z, Yao J, Fazlollahi F, Manley GT. Aquaporin-4 Reduces Post-Traumatic Seizure Susceptibility by Promoting Astrocytic Glial Scar Formation in Mice. J Neurotrauma. 2011 Sep 22. [Epub ahead of print].

Sughrue ME, Bloch OG, Manley GT, Stiver SI. Marked reduction in wound complication rates following decompressive hemicraniectomy with an improved operative closure technique. J Clin Neurosci 2011;18(9):1201-5.

Flint AC, Gean AD, Manley GT, Rao VA, Sheridan WF, von Koch CS. Temporizing treatment of hyperacute subdural hemorrhage by subdural evacuation port system placement. J Neurosurg 2011;115(4):844-8.

Beattie MS, Manley GT. Tight squeeze, slow burn: inflammation and the aetiology of cervical myelopathy. Brain 2011;134(Pt 5):1259-61.

Maas AI, Menon DK, Lingsma HF, Pineda JA, Sandel ME, Manley GT. Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research. J Neurotrauma 2012;29(1):32-46.

Nakagawa A, Manley GT, Gean AD, Ohtani K, Armonda R, Tsukamoto A, Yamamoto H, Takayama K, Tominaga T. Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research. J Neurotrauma 2011;28(6):1101-19.

Sorani MD, Manley GT, Claude Hemphill J, Baranzini SE. Dynamic, multi-level network models of clinical trials. Pac Symp Biocomput 2011:38-49.

Monson KL, Matsumoto MM, Young WL, Manley GT, Hashimoto T. Abrupt increase in rat carotid blood flow induces rapid alteration of artery mechanical properties. J Mech Behav Biomed Mater 2011;4(1):9-15.

Nakagawa K, Hills NK, Kamel H, Morabito, Diane, Patel PV, Manley GT, Hemphill JC 3rd. The effect of decompressive hemicraniectomy on brain temperature after severe brain injury. Neurocrit Care 2011;15(1):101-6.

Whyte J, Vasterling J, Manley GT. Common data elements for research on traumatic brain injury and psychological health: current status and future development. Arch Phys Med Rehabil 2010;91(11):1692-6.

Manley GT, Diaz-Arrastia R, Brophy M, Engel D, Goodman C, Gwinn K, Veenstra TD, Ling G, Ottens AK, Tortella F, Hayes RL. Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group. Arch Phys Med Rehabil 2010;91(11):1667-72.

Gean AD, Fischbein NJ, Purcell DD, Aiken AH, Manley GT, Stiver SI. Benign anterior temporal epidural hematoma: indolent lesion with a characteristic CT imaging appearance after blunt head trauma. Radiology 2010;257(1):212-8.

Rosenthal G, Sanchez-Mejia RO, Phan N, Hemphill JC 3rd, Martin C, Manley GT. Incorporating a parenchymal thermal diffusion cerebral blood flow probe in bedside assessment of cerebral autoregulation and vasoreactivity in patients with severe traumatic brain injury. J Neurosurg 2011;114(1):62-70.

Maas AI, Roozenbeek B, Manley GT. Clinical trials in traumatic brain injury: past experience and current developments. Neurotherapeutics 2010;7(1):115-26.

Cohen MJ, Grossman AD, Morabito D, Knudson MM, Butte AJ, Manley GT. Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care 2010;14(1):R10.

Voytek B, Secundo L, Bidet-Caulet A, Scabini D, Stiver SI, Gean AD, Manley GT, Knight RT. Hemicraniectomy: a new model for human electrophysiology with high spatio-temporal resolution. J Cogn Neurosci 2010;22(11):2491-502.

Chun KA, Manley GT, Stiver SI, Aiken AH, Phan N, Wang V, Meeker M, Cheng SC, Gean AD, Wintermark M. Interobserver variability in the assessment of CT imaging features of traumatic brain injury. J Neurotrauma 2010;27(2):325-30.

Grossman AD, Cohen MJ, Manley GT, Butte AJ. Infection in the intensive care unit alters physiological networks. BMC Bioinformatics 2009;10 Suppl 9:S4.

Wan JJ, Cohen MJ, Rosenthal G, Haitsma IK, Morabito DJ, Derugin N, Knudson MM, Manley GT. Refining resuscitation strategies using tissue oxygen and perfusion monitoring in critical organ beds. J Trauma 2009;66(2):353-7.