Nalin Gupta MD, PhD

Associate Professor in Residence of Neurological Surgery and Pediatrics

Dennis Bruce Dettmer Endowed Chair in Pediatric Neurosurgery

Director, Pediatric Neurological Surgery Program

Principal Investigator, Brain Tumor Research Center

Director of the Department's Pediatric Neurological Surgery Program, Dr. Gupta has specialty interests in the evaluation and surgical management of neurological disorders in children, including such conditions as brain tumors, hydrocephalus, cranial and spinal congenital anomalies, and epilepsy. After his residency training in neurological surgery at the University of Toronto in Ontario, Canada, he completed fellowship training in pediatric neurosurgery at the Hospital for Sick Children in Toronto.

Dr.Gupta's research interests include fundamental mechanisms of brain tumor progression and defining the biological response of tumors to various treatment strategies. During his graduate studies, Dr. Gupta studied the effect of radiation and chemotherapy agents on glioma cells as they progress through the cell cycle.. Currently, his laboratory is focusing on cell-cell interactions during tumor progression, and the special role of pro-inflammatory cytokines. Dr. Gupta is also Co-PI of the Pediatric Brain Tumor Foundation Institute Award at UCSF. This program is directed towards basic and translational research for brainstem glioma and medulloblastoma.

Education, Training, and Previous Positions

1983: BS, McGill University, Montreal, Canada
1987: MD, University of Toronto, Canada
1987-1988: Surgical Internship, Mount Sinai Hospital, Faculty of Medicine, University of Toronto
1988-1989: Resident in Neurosurgery, University of Ottawa, Canada
1989-1997: Resident in Neurosurgery, Department of Neurosurgery, University of Toronto
1991-1996 Research Fellow, Medical Research Council of Canada and Brain Tumor Research Center, Department of Neurological Surgery, UCSF
1992-1996: PhD, Graduate Group in Biophysics, UCSF
1997-1998: Fellow in Pediatric Neurosurgery, Hospital for Sick Children, University of Toronto
1998-2000: Clinical Associate, Section of Neurosurgery, Department of Surgery, University of Chicago

Selected Professional Memberships and Appointments

American Association of Cancer Research
American Association of Neurological Surgery
American Society of Pediatric Neurosurgeons
Congress of Neurological Surgeons
Joint Section on tumors, AANS/CNS
Joint Section on Pediatric Neurosurgery, AANS/CNS
Society of Neuro-Oncology

Selected Honors and Awards

1981: J.W. McConnell Scholarship, McGill University
1988: Outstanding Intern, Department of Emergency Medicine, Mount Sinai Hospital
1995: Junior Scientist Travel Award, International Congress of Radiation Research
1995: T.P. Morley Resident Research Award, Division of Neurosurgery, University of Toronto
1997: Alan Hudson Resident Teaching Award, Division of Neurosurgery, University of Toronto
2002: Hellman Family Award for Early Faculty, UCSF Cancer Center
2004: SPORE Career Development Award, Department of Neurological Surgery, UCSF
2005: NIH/NINDS K08 Career Development Award

Selected Recent Publications

NS Adzick, EA Thom, CY Spong, JW Brock, PK Burrows, MP Johnson, LJ Howell, JA Farrell, ME Dabrowiak, LN Sutton, N Gupta, NB Tulipan, ME D’Alton, DL Farmer, MOMS Investigators. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med 364:993-1004, 2011

N Sanai, T Nguyen, RA Ihrie, Z Mirzadeh, H Tsai, M Wong, N Gupta, MS Berger, E Huang, J Garcia-Verdugo, DH Rowitch, A Alvarez-Buylla. Corridors of migratory neurons in human brain and their depletion during infancy. Nature 478:xxx, 2011

Hetts SW, Narvid J, Sanai N, Lawton MT, Gupta N, Fullerton HJ, Dowd CF, Higashida RT, Halbach VV. Intracranial Aneurysms in Childhood: 27-Year Single-Institution Experience. AJNR Am J Neuroradiol 30:1315-1324. 2009

McBride SM, Daganzo SM, Banerjee A, Gupta N, Lamborn KR, Prados MD, Berger MS, Wara WM, Haas-Kogan DA. Radiation is an Important Component of Multimodality Therapy for Pediatric Non-Pineal Supratentorial Primitive Neuroectodermal Tumors. Int J Radiat Oncol Biol Phys 73:1319-1323, 2008

Smith AB, Gupta N, Strober J, Chin C. Magnetic resonance neurography in children with birth-related brachial plexus injury. Pediatr Radiol 38(2):159-63, 2008

Liang Y, Bollen AW, Gupta N. CC chemokine receptor-2A is frequently overexpressed in glioblastoma. J Neurooncol 86(2):153-63, 2008

Liang Y, Diehn M, Bollen AW, Israel MA, Gupta N. Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment. J Neurooncol 86(2):133-41, 2008

Dinca EB, Sarkaria JN, Schroeder MA, Carlson BL, Voicu R, Gupta N, Berger MS, James CD. Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy. J Neurosurg 107(3):610-6, 2007

Wu Y, Green NL, Wrensch MR, Zhao S, Gupta N. Ventriculoperitoneal shunt complications in California: 1990 to 2000. Neurosurgery 61(3):557-62, 2007

Gupta N, Park J, Solomon C, Kranz DA, Wrensch M, Wu YW. Long-term outcomes in patients with treated childhood hydrocephalus. J Neurosurg 106(5 Suppl):334-9, 2007

Liang Y, Bollen AW, Aldape KD, Gupta N. Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma. BMC Cancer 6:97, 2006

Steinbok P, Garton HJ, Gupta N. Occult tethered cord syndrome: a survey of practice patterns. J Neurosurg 104(5 Suppl):309-13, 2006

Mishra KK, Puri DR, Missett BT, Lamborn KR, Prados MD, Berger MS, Banerjee A, Gupta N, Wara WM, Haas-Kogan DA. The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas. Neuro Oncol 8(2):166-74, 2006

Liang Y, Bollen AW, Nicholas MK, Gupta N. Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. BMC Clin Pathol 5:6, 2005