Nalin Gupta MD, PhD

Nalin Gupta MD, PhD

Professor in Residence of Neurological Surgery and Pediatrics

Dennis Bruce Dettmer Endowed Chair in Pediatric Neurosurgery

Director, Pediatric Neurological Surgery Program

Principal Investigator, Brain Tumor Center

Director of the Department's Pediatric Neurological Surgery Program, Dr. Gupta has specialty interests in the evaluation and surgical management of neurological disorders in children, including such conditions as brain tumors, hydrocephalus, cranial and spinal congenital anomalies, and epilepsy. After his residency training in neurological surgery at the University of Toronto in Ontario, Canada, he completed fellowship training in pediatric neurosurgery at the Hospital for Sick Children in Toronto.

Dr.Gupta's research interests include fundamental mechanisms of brain tumor progression and defining the biological response of tumors to various treatment strategies. During his graduate studies, Dr. Gupta studied the effect of radiation and chemotherapy agents on glioma cells as they progress through the cell cycle.. Currently, his laboratory is focusing on cell-cell interactions during tumor progression, and the special role of pro-inflammatory cytokines. Dr. Gupta is also Co-PI of the Pediatric Brain Tumor Foundation Institute Award at UCSF. This program is directed towards basic and translational research for brainstem glioma and medulloblastoma.

Education, Training, and Previous Positions

1983: BS, McGill University, Montreal, Canada
1987: MD, University of Toronto, Canada
1987-1988: Surgical Internship, Mount Sinai Hospital, Faculty of Medicine, University of Toronto
1988-1989: Resident in Neurosurgery, University of Ottawa, Canada
1989-1997: Resident in Neurosurgery, Department of Neurosurgery, University of Toronto
1991-1996 Research Fellow, Medical Research Council of Canada and Brain Tumor Research Center, Department of Neurological Surgery, UCSF
1992-1996: PhD, Graduate Group in Biophysics, UCSF
1997-1998: Fellow in Pediatric Neurosurgery, Hospital for Sick Children, University of Toronto
1998-2000: Clinical Associate, Section of Neurosurgery, Department of Surgery, University of Chicago

Selected Professional Memberships and Appointments

American Association of Cancer Research
American Association of Neurological Surgery
American Society of Pediatric Neurosurgeons
Congress of Neurological Surgeons
Joint Section on tumors, AANS/CNS
Joint Section on Pediatric Neurosurgery, AANS/CNS
Society of Neuro-Oncology

Selected Honors and Awards

1981: J.W. McConnell Scholarship, McGill University
1988: Outstanding Intern, Department of Emergency Medicine, Mount Sinai Hospital
1995: Junior Scientist Travel Award, International Congress of Radiation Research
1995: T.P. Morley Resident Research Award, Division of Neurosurgery, University of Toronto
1997: Alan Hudson Resident Teaching Award, Division of Neurosurgery, University of Toronto
2002: Hellman Family Award for Early Faculty, UCSF Cancer Center
2004: SPORE Career Development Award, Department of Neurological Surgery, UCSF
2005: NIH/NINDS K08 Career Development Award

Selected Recent Publications

Gupta N, Goumnerova LC, Manley P, Chi SN, Neuberg D, Puligandla M, Fangusaro J, Goldman S, Tomita T, Alden T, DiPatri A, Rubin JB, Gauvain K, Limbrick D, Leonard J, Geyer JR, Leary S, Browd S, Wang Z, Sood S, Bendel A, Nagib M, Gardner S, Karajannis MA, Harter D, Ayyanar K, Gump W, Bowers DC, Weprin B, MacDonald TJ, Aguilera D, Brahma B, Robison NJ, Kiehna E, Krieger M, Sandler E, Aldana P, Khatib Z, Ragheb J, Bhatia S, Mueller S, Banerjee A, Bredlau AL, Gururangan S, Fuchs H, Cohen KJ, Jallo G, Dorris K, Handler M, Comito M, Dias M, Nazemi K, Baird L, Murray J, Lindeman N, Hornick JL, Malkin H, Sinai C, Greenspan L, Wright KD, Prados M, Bandopadhayay P, Ligon KL, Kieran MW. Prospective Feasibility and Safety Assessment of Surgical Biopsy for Patients with Newly Diagnosed Diffuse Intrinsic Pontine Glioma. Neuro Oncol. 2018 May 5. doi: 10.1093/neuonc/noy070. [Epub ahead of print] PubMed PMID: 29741745.

Iorgulescu JB, Van Ziffle J, Stevers M, Grenert JP, Bastian BC, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, Pfister S, Korshunov A, Perry A, Solomon DA. Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation. Acta Neuropathol. 2018 Apr;135(4):635-638. doi: 10.1007/s00401-018-1819-x. Epub 2018 Feb 12. PubMed PMID: 29435664.

Farmer DL, Thom EA, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Gupta N, Adzick NS; Management of Myelomeningocele Study Investigators. The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes. Am J Obstet Gynecol. 2018 Feb;218(2):256.e1-256.e13. doi: 10.1016/j.ajog.2017.12.001. Epub 2017 Dec 12. PubMed PMID: 29246577.

Louis N, Liu S, He X, Drummond DC, Noble CO, Goldman S, Mueller S, Bankiewicz K, Gupta N, Hashizume R. New therapeutic approaches for brainstem tumors: a comparison of delivery routes using nanoliposomal irinotecan in an animal model. J Neurooncol. 2018 Feb;136(3):475-484. doi: 10.1007/s11060-017-2681-8. Epub 2017 Nov 23. PubMed PMID: 29170909; PubMed Central PMCID: PMC5807192.

Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA. Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. Acta Neuropathol. 2017 Oct;134(4):671-673. doi: 10.1007/s00401-017-1759-x. Epub 2017 Aug 3. PubMed PMID: 28776091; PubMed Central PMCID: PMC5693679.

Gupta N. Surgical techniques for open fetal repair of myelomeningocele. Childs Nerv Syst. 2017 Jul;33(7):1143-1148. doi: 10.1007/s00381-017-3439-5. Epub 2017 May 16. Review. PubMed PMID: 28510071.

Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 May 1;19(5):699-709. doi: 10.1093/neuonc/now254. PubMed PMID: 28453743; PubMed Central PMCID: PMC5464451.

Rutkowski MJ, Birk HS, Wood MD, Perry A, Nicolaides T, Ames CP, Gupta N. Metastatic clival chordoma: a case report of multiple extraneural metastases following resection and proton beam radiotherapy in a 5-year old boy. J Neurosurg Pediatr. 2017 May;19(5):531-537. doi: 10.3171/2017.1.PEDS16549. Epub 2017 Mar 17. PubMed PMID: 28304223.

Behfar MH, Abada E, Sydanheimo L, Goldman K, Fleischman AJ, Gupta N, Ukkonen L, Roy S. Inductive passive sensor for intraparenchymal and intraventricular monitoring of intracranial pressure. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:1950-1954. doi: 10.1109/EMBC.2016.7591105. PubMed PMID: 28268710.

Olow A, Mueller S, Yang X, Hashizume R, Meyerowitz J, Weiss W, Resnick AC, Waanders AJ, Stalpers LJ, Berger MS, Gupta N, James CD, Petritsch CK, Haas-Kogan DA. BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas. Clin Cancer Res. 2016 Nov 1;22(21):5312-5321. Epub 2016 May 23. PubMed PMID: 27217440; PubMed Central PMCID: PMC5093033.

Feng X, Jopson TD, Paladini MS, Liu S, West BL, Gupta N, Rosi S. Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits. J Neuroinflammation. 2016 Aug 30;13(1):215. doi: 10.1186/s12974-016-0671-y. PubMed PMID: 27576527; PubMed Central PMCID: PMC5006433.

Jones C, Karajannis MA, Jones DTW, Kieran MW, Monje M, Baker SJ, Becher OJ, Cho YJ, Gupta N, Hawkins C, Hargrave D, Haas-Kogan DA, Jabado N, Li XN, Mueller S, Nicolaides T, Packer RJ, Persson AI, Phillips JJ, Simonds EF, Stafford JM, Tang Y, Pfister SM, Weiss WA. Pediatric high-grade glioma: biologically and clinically in need of new thinking. Neuro Oncol. 2017 Feb 1;19(2):153-161. doi: 10.1093/neuonc/now101. Review. PubMed PMID: 27282398; PubMed Central PMCID: PMC5464243.

Hashizume R, Gupta N. Patient-derived Tumor Models for Diffuse Intrinsic Pontine Gliomas. Curr Neuropharmacol. 2017;15(1):98-103. Review. PubMed PMID: 27212051; PubMed Central PMCID: PMC5327452.

Rutledge WC, Choudhri O, Walcott BP, Benet A, Fox CK, Gupta N, Lawton MT. Indirect and direct revascularization of ACTA2 cerebral arteriopathy: feasibility of the superficial temporal artery to anterior cerebral artery bypass with posterior auricular artery interposition graft: case report. J Neurosurg Pediatr. 2016 Sep;18(3):339-43. doi: 10.3171/2016.3.PEDS15694. Epub 2016 May 13. PubMed PMID: 27176728.

Ferris SP, Goode B, Joseph NM, Kline CN, Samuel D, Gupta N, Bollen A, Perry A, Mueller S, Solomon DA. IDH1 mutation can be present in diffuse astrocytomas and giant cell glioblastomas of young children under 10 years of age. Acta Neuropathol. 2016 Jul;132(1):153-5. doi: 10.1007/s00401-016-1579-4. Epub 2016 May 9. PubMed PMID: 27161253; PubMed Central PMCID: PMC4915961.

Kieran MW, Goumnerova LC, Prados M, Gupta N. Biopsy for diffuse intrinsic pontine glioma: a reappraisal. J Neurosurg Pediatr. 2016 Sep;18(3):390-1. doi: 10.3171/2015.6.PEDS15374. Epub 2016 May 6. PubMed PMID: 27153377.

Morganti JM, Riparip LK, Chou A, Liu S, Gupta N, Rosi S. Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury. J Neuroinflammation. 2016 Apr 18;13(1):80. doi: 10.1186/s12974-016-0547-1. PubMed PMID: 27090212; PubMed Central PMCID: PMC4835854.

Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Gururangan S, McLendon RE, Bigner DD, Lipp ES, Perreault S, Cho YJ, Grant G, Kim SK, Lee JY, Rao AAN, Giannini C, Li KKW, Ng HK, Yao Y, Kumabe T, Tominaga T, Grajkowska WA, Perek-Polnik M, Low DCY, Seow WT, Chang KTE, Mora J, Pollack IF, Hamilton RL, Leary S, Moore AS, Ingram WJ, Hallahan AR, Jouvet A, Fèvre-Montange M, Vasiljevic A, Faure-Conter C, Shofuda T, Kagawa N, Hashimoto N, Jabado N, Weil AG, Gayden T, Wataya T, Shalaby T, Grotzer M, Zitterbart K, Sterba J, Kren L, Hortobágyi T, Klekner A, László B, Pócza T, Hauser P, Schüller U, Jung S, Jang WY, French PJ, Kros JM, van Veelen MC, Massimi L, Leonard JR, Rubin JB, Vibhakar R, Chambless LB, Cooper MK, Thompson RC, Faria CC, Carvalho A, Nunes S, Pimentel J, Fan X, Muraszko KM, López-Aguilar E, Lyden D, Garzia L, Shih DJH, Kijima N, Schneider C, Adamski J, Northcott PA, Kool M, Jones DTW, Chan JA, Nikolic A, Garre ML, Van Meir EG, Osuka S, Olson JJ, Jahangiri A, Castro BA, Gupta N, Weiss WA, Moxon-Emre I, Mabbott DJ, Lassaletta A, Hawkins CE, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka JT, Korshunov A, Pfister SM, Packer RJ, Ramaswamy V, Taylor MD. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis. Lancet Oncol. 2016 Apr;17(4):484-495. doi: 10.1016/S1470-2045(15)00581-1. Epub 2016 Mar 12. PubMed PMID: 26976201; PubMed Central PMCID: PMC4907853.

Worthen M, Leonard TH, Blair TR, Gupta N. Experiences of Parents Caring for Infants with Rare Scalp Mass as Identified through a Disease-Specific Blog. J Am Board Fam Med. 2015 Nov-Dec;28(6):750-8. doi: 10.3122/jabfm.2015.06.150080. PubMed PMID: 26546650.

Solomon DA, Wood MD, Tihan T, Bollen AW, Gupta N, Phillips JJ, Perry A. Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Brain Pathol. 2016 Sep;26(5):569-80. doi: 10.1111/bpa.12336. Epub 2015 Dec 14. PubMed PMID: 26517431.

Tulipan N, Wellons JC 3rd, Thom EA, Gupta N, Sutton LN, Burrows PK, Farmer D, Walsh W, Johnson MP, Rand L, Tolivaisa S, D'alton ME, Adzick NS; MOMS Investigators. Prenatal surgery for myelomeningocele and the need for cerebrospinal fluid shunt placement. J Neurosurg Pediatr. 2015 Dec;16(6):613-20. doi: 10.3171/2015.7.PEDS15336. Epub 2015 Sep 15. PubMed PMID: 26369371; PubMed Central PMCID: PMC5206797.

Simon NG, Franz CK, Gupta N, Alden T, Kliot M. Central Adaptation following Brachial Plexus Injury. World Neurosurg. 2016 Jan;85:325-32. doi: 10.1016/j.wneu.2015.09.027. Epub 2015 Sep 25. Review. PubMed PMID: 26409073.

Barajas RF Jr, Phelps A, Foster HC, Courtier J, Buelow BD, Gupta N, Nicolaides T, Glenn OA, Banerjee A. Metastatic Diffuse Intrinsic Pontine Glioma to the Peritoneal Cavity Via Ventriculoperitoneal Shunt: Case Report and Literature Review. J Neurol Surg Rep. 2015 Jul;76(1):e91-6. doi: 10.1055/s-0035-1547365. Epub 2015 Apr 27. PubMed PMID: 26251821; PubMed Central PMCID: PMC4520967.

Seymour ZA, Sneed PK, Gupta N, Lawton MT, Molinaro AM, Young W, Dowd CF, Halbach VV, Higashida RT, McDermott MW. Volume-staged radiosurgery for large arteriovenous malformations: an evolving paradigm. J Neurosurg. 2016 Jan;124(1):163-74. doi: 10.3171/2014.12.JNS141308. Epub 2015 Jul 3. PubMed PMID: 26140495.

Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz HJ, Ryzhova M, Mack S, Ramaswamy V, Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Toledano H, Avigad S, Hoffman LM, Donson AM, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong TS, Gupta N, Allen JC, Karajannis MA, Zagzag D, Hasselblatt M, Kulozik AE, Witt O, Collins VP, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo ML, von Deimling A, Lichter P, Taylor MD, Gilbertson R, Ellison DW, Aldape K, Korshunov A, Kool M, Pfister SM. Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. Cancer Cell. 2015 May 11;27(5):728-43. doi: 10.1016/j.ccell.2015.04.002. PubMed PMID: 25965575; PubMed Central PMCID: PMC4712639.

Mack SC, Agnihotri S, Bertrand KC, Wang X, Shih DJ, Witt H, Hill N, Zayne K, Barszczyk M, Ramaswamy V, Remke M, Thompson Y, Ryzhova M, Massimi L, Grajkowska W, Lach B, Gupta N, Weiss WA, Guha A, Hawkins C, Croul S, Rutka JT, Pfister SM, Korshunov A, Pekmezci M, Tihan T, Philips JJ, Jabado N, Zadeh G, Taylor MD. Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype. Clin Cancer Res. 2015 Aug 15;21(16):3750-8. doi: 10.1158/1078-0432.CCR-14-2650. Epub 2015 May 8. PubMed PMID: 25957288; PubMed Central PMCID: PMC4537825.

Morganti JM, Jopson TD, Liu S, Riparip LK, Guandique CK, Gupta N, Ferguson AR, Rosi S. CCR2 antagonism alters brain macrophage polarization and ameliorates cognitive dysfunction induced by traumatic brain injury. J Neurosci. 2015 Jan 14;35(2):748-60. doi: 10.1523/JNEUROSCI.2405-14.2015. PubMed PMID: 25589768; PubMed Central PMCID: PMC4293420.

Zhukova N, Ramaswamy V, Remke M, et al. WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. Acta Neuropathol Commun. 2014 Dec 24;2:174. doi: 10.1186/s40478-014-0174-y. PubMed PMID: 25539912; PubMed Central PMCID: PMC4297452.

Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec;20(12):1394-6. doi: 10.1038/nm.3716. Epub 2014 Nov 17. PubMed PMID: 25401693; PubMed Central PMCID: PMC4257862.

Schoenfeld A, Haas-Kogan DA, Molinaro A, Banerjee A, Nicolaides T, Tihan T, Bollen AW, Gupta N, Mueller S. Pure germinomas of the central nervous system: treatment strategies and outcomes. J Neurooncol. 2014 Dec;120(3):643-9. doi: 10.1007/s11060-014-1599-7. Epub 2014 Sep 5. PubMed PMID: 25189788.

Zygourakis CC, Davis JL, Kaur G, Ames CP, Gupta N, Auguste KI, Parsa AT. Management of central nervous system teratoma. J Clin Neurosci. 2015 Jan;22(1):98-104. doi: 10.1016/j.jocn.2014.03.039. Epub 2014 Aug 21. PubMed PMID: 25150764.

Silvestrini MT, Yin D, Martin AJ, Coppes VG, Mann P, Larson PS, Starr PA, Zeng X, Gupta N, Panter SS, Desai TA, Lim DA. Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment. Mol Ther. 2015 Jan;23(1):119-29. doi: 10.1038/mt.2014.155. Epub 2014 Aug 20. PubMed PMID: 25138755.

Englot DJ, Han SJ, Rolston JD, Ivan ME, Kuperman RA, Chang EF, Gupta N, Sullivan JE, Auguste KI. Epilepsy surgery failure in children: a quantitative and qualitative analysis. J Neurosurg Pediatr. 2014 Oct;14(4):386-95. doi: 10.3171/2014.7.PEDS13658. Epub 2014 Aug 15. Erratum in: J Neurosurg Pediatr. 2014 Oct;14(4):437. PubMed PMID: 25127098; PubMed Central PMCID: PMC4393949.

Sun MZ, Ivan ME, Oh MC, Delance AR, Clark AJ, Safaee M, Oh T, Kaur G, Molinaro A, Gupta N, Parsa AT. Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014 Nov;120(2):353-60. doi: 10.1007/s11060-014-1559-2. Epub 2014 Aug 9. PubMed PMID: 25106865.

Cheng JS, Ivan ME, Stapleton CJ, Quinones-Hinojosa A, Gupta N, Auguste KI. Response. J Neurosurg Pediatr. 2014 Jun;13(6):590. PubMed PMID: 25006643.

Potts MB, Sheth SA, Louie J, Smyth MD, Sneed PK, McDermott MW, Lawton MT, Young WL, Hetts SW, Fullerton HJ, Gupta N. Stereotactic radiosurgery at a low marginal dose for the treatment of pediatric arteriovenous malformations: obliteration, complications, and functional outcomes. J Neurosurg Pediatr. 2014 Jul;14(1):1-11. doi: 10.3171/2014.3.PEDS13381. Epub 2014 Apr 25. PubMed PMID: 24766309.

Cheng JS, Ivan ME, Stapleton CJ, Quinones-Hinojosa A, Gupta N, Auguste KI. Intraoperative changes in transcranial motor evoked potentials and somatosensory evoked potentials predicting outcome in children with intramedullary spinal cord tumors. J Neurosurg Pediatr. 2014 Jun;13(6):591-9. doi: 10.3171/2014.2.PEDS1392. Epub 2014 Apr 4. PubMed PMID: 24702615; PubMed Central PMCID: PMC4322892.

Morganti JM, Jopson TD, Liu S, Gupta N, Rosi S. Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration. PLoS One. 2014 Apr 2;9(4):e93650. doi: 10.1371/journal.pone.0093650. eCollection 2014. PubMed PMID: 24695541; PubMed Central PMCID: PMC3973545.

Potts MB, Jahangiri A, Jen M, Sneed PK, McDermott MW, Gupta N, Hetts SW, Young WL, Lawton MT; UCSF Brain AVM Study Project. Deep arteriovenous malformations in the basal ganglia, thalamus, and insula: multimodality management, patient selection, and results. World Neurosurg. 2014 Sep-Oct;82(3-4):386-94. doi: 10.1016/j.wneu.2014.03.033. Epub 2014 Mar 19. PubMed PMID: 24657255; PubMed Central PMCID: PMC4169357.

Safaee M, Oh MC, Mummaneni PV, Weinstein PR, Ames CP, Chou D, Berger MS, Parsa AT, Gupta N. Surgical outcomes in spinal cord ependymomas and the importance of extent of resection in children and young adults. J Neurosurg Pediatr. 2014 Apr;13(4):393-9. doi: 10.3171/2013.12.PEDS13383. Epub 2014 Feb 7. PubMed PMID: 24506340.

Mueller S, Hashizume R, Yang X, Kolkowitz I, Olow AK, Phillips J, Smirnov I, Tom MW, Prados MD, James CD, Berger MS, Gupta N, Haas-Kogan DA. Targeting Wee1 for the treatment of pediatric high-grade gliomas. Neuro Oncol. 2014 Mar;16(3):352-60. doi: 10.1093/neuonc/not220. Epub 2013 Dec 4. PubMed PMID: 24305702; PubMed Central PMCID: PMC3922515.

Sun MZ, Ivan ME, Clark AJ, Oh MC, Delance AR, Oh T, Safaee M, Kaur G, Bloch O, Molinaro A, Gupta N, Parsa AT. Gross total resection improves overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014 Jan;116(1):179-85. doi: 10.1007/s11060-013-1281-5. Epub 2013 Oct 29. PubMed PMID: 24166581.

Rana M, Gupta N, Dalboni Da Rocha JL, Lee S, Sitaram R. A toolbox for real-time subject-independent and subject-dependent classification of brain states from fMRI signals. Front Neurosci. 2013 Oct 17;7:170. doi: 10.3389/fnins.2013.00170. eCollection 2013. PubMed PMID: 24151454; PubMed Central PMCID: PMC3798026.

Sheth SA, Potts MB, Sneed PK, Young WL, Cooke DL, Gupta N, Hetts SW. Angiographic features help predict outcome after stereotactic radiosurgery for the treatment of pediatric arteriovenous malformations. Childs Nerv Syst. 2014 Feb;30(2):241-7. doi: 10.1007/s00381-013-2231-4. Epub 2013 Jul 27. PubMed PMID: 23892391.

Englot DJ, Rutkowski MJ, Ivan ME, Sun PP, Kuperman RA, Chang EF, Gupta N, Sullivan JE, Auguste KI. Effects of temporal lobectomy on consciousness-impairing and consciousness-sparing seizures in children. Childs Nerv Syst. 2013 Oct;29(10):1915-22. doi: 10.1007/s00381-013-2168-7. Epub 2013 May 31. PubMed PMID: 23723065.

Cage TA, Samagh SP, Mueller S, Nicolaides T, Haas-Kogan D, Prados M, Banerjee A, Auguste KI, Gupta N. Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. Childs Nerv Syst. 2013 Aug;29(8):1313-9. doi: 10.1007/s00381-013-2101-0. Epub 2013 May 11. PubMed PMID: 23666401.

Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, Sarkaria J, Zhang Z. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 2013 May 1;27(9):985-90. doi: 10.1101/gad.217778.113. Epub 2013 Apr 19. PubMed PMID: 23603901; PubMed Central PMCID: PMC3656328.

Cage TA, Clark AJ, Aranda D, Gupta N, Sun PP, Parsa AT, Auguste KI. A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas. J Neurosurg Pediatr. 2013 Jun;11(6):673-81. doi: 10.3171/2013.2.PEDS12345. Epub 2013 Mar 29. Review. PubMed PMID: 23540528.

Safaee M, Clark AJ, Bloch O, Oh MC, Singh A, Auguste KI, Gupta N, McDermott MW, Aghi MK, Berger MS, Parsa AT. Surgical outcomes in choroid plexus papillomas: an institutional experience. J Neurooncol. 2013 May;113(1):117-25. doi: 10.1007/s11060-013-1097-3. Epub 2013 Mar 7. PubMed PMID: 23468001.

Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim DA. Radially branched deployment for more efficient cell transplantation at the scale of the human brain. Stereotact Funct Neurosurg. 2013;91(2):92-103. doi: 10.1159/000343213. Epub 2013 Jan 22. PubMed PMID: 23343609; PubMed Central PMCID: PMC3739996.

Oh MC, Sayegh ET, Safaee M, Sun MZ, Kaur G, Kim JM, Aranda D, Molinaro AM, Gupta N, Parsa AT. Prognosis by tumor location for pediatric spinal cord ependymomas. J Neurosurg Pediatr. 2013 Mar;11(3):282-8. doi: 10.3171/2012.11.PEDS12292. Epub 2012 Dec 21. PubMed PMID: 23259510.

Fogh S, Ma L, Gupta N, Sahgal A, Nakamura JL, Barani I, Sneed PK, McDermott M, Larson DA. High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations. J Neurosurg. 2012 Dec;117 Suppl:115-9. doi: 10.3171/2012.7.GKS121023. PubMed PMID: 23205798.

Silber J, Hashizume R, Felix T, Hariono S, Yu M, Berger MS, Huse JT, VandenBerg SR, James CD, Hodgson JG, Gupta N. Expression of miR-124 inhibits growth of medulloblastoma cells. Neuro Oncol. 2013 Jan;15(1):83-90. doi: 10.1093/neuonc/nos281. Epub 2012 Nov 21. PubMed PMID: 23172372; PubMed Central PMCID: PMC3534424.

Clark AJ, Cage TA, Aranda D, Parsa AT, Sun PP, Auguste KI, Gupta N. A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Childs Nerv Syst. 2013 Feb;29(2):231-8. doi: 10.1007/s00381-012-1926-2. Epub 2012 Oct 23. Review. PubMed PMID: 23089933.

Gupta N, Henry RG, Strober J, Kang SM, Lim DA, Bucci M, Caverzasi E, Gaetano L, Mandelli ML, Ryan T, Perry R, Farrell J, Jeremy RJ, Ulman M, Huhn SL, Barkovich AJ, Rowitch DH. Neural stem cell engraftment and myelination in the human brain. Sci Transl Med. 2012 Oct 10;4(155):155ra137. doi: 10.1126/scitranslmed.3004373. Erratum in: Sci Transl Med. 2012 Dec 19;4(165):165er8. PubMed PMID: 23052294; PubMed Central PMCID: PMC3893824.

Hashizume R, Smirnov I, Liu S, Phillips JJ, Hyer J, McKnight TR, Wendland M, Prados M, Banerjee A, Nicolaides T, Mueller S, James CD, Gupta N. Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment. J Neurooncol. 2012 Dec;110(3):305-13. doi: 10.1007/s11060-012-0973-6. Epub 2012 Sep 17. PubMed PMID: 22983601.

Clark AJ, Cage TA, Aranda D, Parsa AT, Auguste KI, Gupta N. Treatment-related morbidity and the management of pediatric craniopharyngioma: a systematic review. J Neurosurg Pediatr. 2012 Oct;10(4):293-301. doi: 10.3171/2012.7.PEDS11436. Epub 2012 Aug 24. Review. PubMed PMID: 22920295.

NS Adzick, EA Thom, CY Spong, JW Brock, PK Burrows, MP Johnson, LJ Howell, JA Farrell, ME Dabrowiak, LN Sutton, N Gupta, NB Tulipan, ME D’Alton, DL Farmer, MOMS Investigators. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med 364:993-1004, 2011

N Sanai, T Nguyen, RA Ihrie, Z Mirzadeh, H Tsai, M Wong, N Gupta, MS Berger, E Huang, J Garcia-Verdugo, DH Rowitch, A Alvarez-Buylla. Corridors of migratory neurons in human brain and their depletion during infancy. Nature 478:xxx, 2011

Hetts SW, Narvid J, Sanai N, Lawton MT, Gupta N, Fullerton HJ, Dowd CF, Higashida RT, Halbach VV. Intracranial Aneurysms in Childhood: 27-Year Single-Institution Experience. AJNR Am J Neuroradiol 30:1315-1324. 2009

McBride SM, Daganzo SM, Banerjee A, Gupta N, Lamborn KR, Prados MD, Berger MS, Wara WM, Haas-Kogan DA. Radiation is an Important Component of Multimodality Therapy for Pediatric Non-Pineal Supratentorial Primitive Neuroectodermal Tumors. Int J Radiat Oncol Biol Phys 73:1319-1323, 2008
 
Smith AB, Gupta N, Strober J, Chin C. Magnetic resonance neurography in children with birth-related brachial plexus injury. Pediatr Radiol 38(2):159-63, 2008 
 
Liang Y, Bollen AW, Gupta N. CC chemokine receptor-2A is frequently overexpressed in glioblastoma. J Neurooncol 86(2):153-63, 2008 
 
Liang Y, Diehn M, Bollen AW, Israel MA, Gupta N. Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment. J Neurooncol 86(2):133-41, 2008
 
Dinca EB, Sarkaria JN, Schroeder MA, Carlson BL, Voicu R, Gupta N, Berger MS, James CD. Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy. J Neurosurg 107(3):610-6, 2007
 
Wu Y, Green NL, Wrensch MR, Zhao S, Gupta N. Ventriculoperitoneal shunt complications in California: 1990 to 2000. Neurosurgery 61(3):557-62, 2007
 
Gupta N, Park J, Solomon C, Kranz DA, Wrensch M, Wu YW. Long-term outcomes in patients with treated childhood hydrocephalus. J Neurosurg 106(5 Suppl):334-9, 2007
 
Liang Y, Bollen AW, Aldape KD, Gupta N. Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma. BMC Cancer 6:97, 2006
 
Steinbok P, Garton HJ, Gupta N. Occult tethered cord syndrome: a survey of practice patterns. J Neurosurg 104(5 Suppl):309-13, 2006
 
Mishra KK, Puri DR, Missett BT, Lamborn KR, Prados MD, Berger MS, Banerjee A, Gupta N, Wara WM, Haas-Kogan DA. The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas. Neuro Oncol 8(2):166-74, 2006
 
Liang Y, Bollen AW, Nicholas MK, Gupta N. Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. BMC Clin Pathol 5:6, 2005