Nalin Gupta MD, PhD

Nalin Gupta MD, PhD

Professor in Residence of Neurological Surgery and Pediatrics

Dennis Bruce Dettmer Endowed Chair in Pediatric Neurosurgery

Director, Pediatric Neurological Surgery Program

Principal Investigator, Brain Tumor Research Center

Director of the Department's Pediatric Neurological Surgery Program, Dr. Gupta has specialty interests in the evaluation and surgical management of neurological disorders in children, including such conditions as brain tumors, hydrocephalus, cranial and spinal congenital anomalies, and epilepsy. After his residency training in neurological surgery at the University of Toronto in Ontario, Canada, he completed fellowship training in pediatric neurosurgery at the Hospital for Sick Children in Toronto.

Dr.Gupta's research interests include fundamental mechanisms of brain tumor progression and defining the biological response of tumors to various treatment strategies. During his graduate studies, Dr. Gupta studied the effect of radiation and chemotherapy agents on glioma cells as they progress through the cell cycle.. Currently, his laboratory is focusing on cell-cell interactions during tumor progression, and the special role of pro-inflammatory cytokines. Dr. Gupta is also Co-PI of the Pediatric Brain Tumor Foundation Institute Award at UCSF. This program is directed towards basic and translational research for brainstem glioma and medulloblastoma.

Education, Training, and Previous Positions

1983: BS, McGill University, Montreal, Canada
1987: MD, University of Toronto, Canada
1987-1988: Surgical Internship, Mount Sinai Hospital, Faculty of Medicine, University of Toronto
1988-1989: Resident in Neurosurgery, University of Ottawa, Canada
1989-1997: Resident in Neurosurgery, Department of Neurosurgery, University of Toronto
1991-1996 Research Fellow, Medical Research Council of Canada and Brain Tumor Research Center, Department of Neurological Surgery, UCSF
1992-1996: PhD, Graduate Group in Biophysics, UCSF
1997-1998: Fellow in Pediatric Neurosurgery, Hospital for Sick Children, University of Toronto
1998-2000: Clinical Associate, Section of Neurosurgery, Department of Surgery, University of Chicago

Selected Professional Memberships and Appointments

American Association of Cancer Research
American Association of Neurological Surgery
American Society of Pediatric Neurosurgeons
Congress of Neurological Surgeons
Joint Section on tumors, AANS/CNS
Joint Section on Pediatric Neurosurgery, AANS/CNS
Society of Neuro-Oncology

Selected Honors and Awards

1981: J.W. McConnell Scholarship, McGill University
1988: Outstanding Intern, Department of Emergency Medicine, Mount Sinai Hospital
1995: Junior Scientist Travel Award, International Congress of Radiation Research
1995: T.P. Morley Resident Research Award, Division of Neurosurgery, University of Toronto
1997: Alan Hudson Resident Teaching Award, Division of Neurosurgery, University of Toronto
2002: Hellman Family Award for Early Faculty, UCSF Cancer Center
2004: SPORE Career Development Award, Department of Neurological Surgery, UCSF
2005: NIH/NINDS K08 Career Development Award

Selected Recent Publications

Morganti JM, Jopson TD, Liu S, Riparip LK, Guandique CK, Gupta N, Ferguson AR, Rosi S. CCR2 antagonism alters brain macrophage polarization and ameliorates cognitive dysfunction induced by traumatic brain injury. J Neurosci. 2015 Jan 14;35(2):748-60. doi: 10.1523/JNEUROSCI.2405-14.2015. PubMed PMID: 25589768; PubMed Central PMCID: PMC4293420.

Zhukova N, Ramaswamy V, Remke M, et al. WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. Acta Neuropathol Commun. 2014 Dec 24;2:174. doi: 10.1186/s40478-014-0174-y. PubMed PMID: 25539912; PubMed Central PMCID: PMC4297452.

Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec;20(12):1394-6. doi: 10.1038/nm.3716. Epub 2014 Nov 17. PubMed PMID: 25401693; PubMed Central PMCID: PMC4257862.

Schoenfeld A, Haas-Kogan DA, Molinaro A, Banerjee A, Nicolaides T, Tihan T, Bollen AW, Gupta N, Mueller S. Pure germinomas of the central nervous system: treatment strategies and outcomes. J Neurooncol. 2014 Dec;120(3):643-9. doi: 10.1007/s11060-014-1599-7. Epub 2014 Sep 5. PubMed PMID: 25189788.

Zygourakis CC, Davis JL, Kaur G, Ames CP, Gupta N, Auguste KI, Parsa AT. Management of central nervous system teratoma. J Clin Neurosci. 2015 Jan;22(1):98-104. doi: 10.1016/j.jocn.2014.03.039. Epub 2014 Aug 21. PubMed PMID: 25150764.

Silvestrini MT, Yin D, Martin AJ, Coppes VG, Mann P, Larson PS, Starr PA, Zeng X, Gupta N, Panter SS, Desai TA, Lim DA. Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment. Mol Ther. 2015 Jan;23(1):119-29. doi: 10.1038/mt.2014.155. Epub 2014 Aug 20. PubMed PMID: 25138755.

Englot DJ, Han SJ, Rolston JD, Ivan ME, Kuperman RA, Chang EF, Gupta N, Sullivan JE, Auguste KI. Epilepsy surgery failure in children: a quantitative and qualitative analysis. J Neurosurg Pediatr. 2014 Oct;14(4):386-95. doi: 10.3171/2014.7.PEDS13658. Epub 2014 Aug 15. Erratum in: J Neurosurg Pediatr. 2014 Oct;14(4):437. PubMed PMID: 25127098; PubMed Central PMCID: PMC4393949.

Sun MZ, Ivan ME, Oh MC, Delance AR, Clark AJ, Safaee M, Oh T, Kaur G, Molinaro A, Gupta N, Parsa AT. Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014 Nov;120(2):353-60. doi: 10.1007/s11060-014-1559-2. Epub 2014 Aug 9. PubMed PMID: 25106865.

Cheng JS, Ivan ME, Stapleton CJ, Quinones-Hinojosa A, Gupta N, Auguste KI. Response. J Neurosurg Pediatr. 2014 Jun;13(6):590. PubMed PMID: 25006643.

Potts MB, Sheth SA, Louie J, Smyth MD, Sneed PK, McDermott MW, Lawton MT, Young WL, Hetts SW, Fullerton HJ, Gupta N. Stereotactic radiosurgery at a low marginal dose for the treatment of pediatric arteriovenous malformations: obliteration, complications, and functional outcomes. J Neurosurg Pediatr. 2014 Jul;14(1):1-11. doi: 10.3171/2014.3.PEDS13381. Epub 2014 Apr 25. PubMed PMID: 24766309.

Cheng JS, Ivan ME, Stapleton CJ, Quinones-Hinojosa A, Gupta N, Auguste KI. Intraoperative changes in transcranial motor evoked potentials and somatosensory evoked potentials predicting outcome in children with intramedullary spinal cord tumors. J Neurosurg Pediatr. 2014 Jun;13(6):591-9. doi: 10.3171/2014.2.PEDS1392. Epub 2014 Apr 4. PubMed PMID: 24702615; PubMed Central PMCID: PMC4322892.

Morganti JM, Jopson TD, Liu S, Gupta N, Rosi S. Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration. PLoS One. 2014 Apr 2;9(4):e93650. doi: 10.1371/journal.pone.0093650. eCollection 2014. PubMed PMID: 24695541; PubMed Central PMCID: PMC3973545.

Potts MB, Jahangiri A, Jen M, Sneed PK, McDermott MW, Gupta N, Hetts SW, Young WL, Lawton MT; UCSF Brain AVM Study Project. Deep arteriovenous malformations in the basal ganglia, thalamus, and insula: multimodality management, patient selection, and results. World Neurosurg. 2014 Sep-Oct;82(3-4):386-94. doi: 10.1016/j.wneu.2014.03.033. Epub 2014 Mar 19. PubMed PMID: 24657255; PubMed Central PMCID: PMC4169357.

Safaee M, Oh MC, Mummaneni PV, Weinstein PR, Ames CP, Chou D, Berger MS, Parsa AT, Gupta N. Surgical outcomes in spinal cord ependymomas and the importance of extent of resection in children and young adults. J Neurosurg Pediatr. 2014 Apr;13(4):393-9. doi: 10.3171/2013.12.PEDS13383. Epub 2014 Feb 7. PubMed PMID: 24506340.

Mueller S, Hashizume R, Yang X, Kolkowitz I, Olow AK, Phillips J, Smirnov I, Tom MW, Prados MD, James CD, Berger MS, Gupta N, Haas-Kogan DA. Targeting Wee1 for the treatment of pediatric high-grade gliomas. Neuro Oncol. 2014 Mar;16(3):352-60. doi: 10.1093/neuonc/not220. Epub 2013 Dec 4. PubMed PMID: 24305702; PubMed Central PMCID: PMC3922515.

Sun MZ, Ivan ME, Clark AJ, Oh MC, Delance AR, Oh T, Safaee M, Kaur G, Bloch O, Molinaro A, Gupta N, Parsa AT. Gross total resection improves overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014 Jan;116(1):179-85. doi: 10.1007/s11060-013-1281-5. Epub 2013 Oct 29. PubMed PMID: 24166581.

Rana M, Gupta N, Dalboni Da Rocha JL, Lee S, Sitaram R. A toolbox for real-time subject-independent and subject-dependent classification of brain states from fMRI signals. Front Neurosci. 2013 Oct 17;7:170. doi: 10.3389/fnins.2013.00170. eCollection 2013. PubMed PMID: 24151454; PubMed Central PMCID: PMC3798026.

Sheth SA, Potts MB, Sneed PK, Young WL, Cooke DL, Gupta N, Hetts SW. Angiographic features help predict outcome after stereotactic radiosurgery for the treatment of pediatric arteriovenous malformations. Childs Nerv Syst. 2014 Feb;30(2):241-7. doi: 10.1007/s00381-013-2231-4. Epub 2013 Jul 27. PubMed PMID: 23892391.

Englot DJ, Rutkowski MJ, Ivan ME, Sun PP, Kuperman RA, Chang EF, Gupta N, Sullivan JE, Auguste KI. Effects of temporal lobectomy on consciousness-impairing and consciousness-sparing seizures in children. Childs Nerv Syst. 2013 Oct;29(10):1915-22. doi: 10.1007/s00381-013-2168-7. Epub 2013 May 31. PubMed PMID: 23723065.

Cage TA, Samagh SP, Mueller S, Nicolaides T, Haas-Kogan D, Prados M, Banerjee A, Auguste KI, Gupta N. Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. Childs Nerv Syst. 2013 Aug;29(8):1313-9. doi: 10.1007/s00381-013-2101-0. Epub 2013 May 11. PubMed PMID: 23666401.

Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, Sarkaria J, Zhang Z. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 2013 May 1;27(9):985-90. doi: 10.1101/gad.217778.113. Epub 2013 Apr 19. PubMed PMID: 23603901; PubMed Central PMCID: PMC3656328.

Cage TA, Clark AJ, Aranda D, Gupta N, Sun PP, Parsa AT, Auguste KI. A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas. J Neurosurg Pediatr. 2013 Jun;11(6):673-81. doi: 10.3171/2013.2.PEDS12345. Epub 2013 Mar 29. Review. PubMed PMID: 23540528.

Safaee M, Clark AJ, Bloch O, Oh MC, Singh A, Auguste KI, Gupta N, McDermott MW, Aghi MK, Berger MS, Parsa AT. Surgical outcomes in choroid plexus papillomas: an institutional experience. J Neurooncol. 2013 May;113(1):117-25. doi: 10.1007/s11060-013-1097-3. Epub 2013 Mar 7. PubMed PMID: 23468001.

Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim DA. Radially branched deployment for more efficient cell transplantation at the scale of the human brain. Stereotact Funct Neurosurg. 2013;91(2):92-103. doi: 10.1159/000343213. Epub 2013 Jan 22. PubMed PMID: 23343609; PubMed Central PMCID: PMC3739996.

Oh MC, Sayegh ET, Safaee M, Sun MZ, Kaur G, Kim JM, Aranda D, Molinaro AM, Gupta N, Parsa AT. Prognosis by tumor location for pediatric spinal cord ependymomas. J Neurosurg Pediatr. 2013 Mar;11(3):282-8. doi: 10.3171/2012.11.PEDS12292. Epub 2012 Dec 21. PubMed PMID: 23259510.

Fogh S, Ma L, Gupta N, Sahgal A, Nakamura JL, Barani I, Sneed PK, McDermott M, Larson DA. High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations. J Neurosurg. 2012 Dec;117 Suppl:115-9. doi: 10.3171/2012.7.GKS121023. PubMed PMID: 23205798.

Silber J, Hashizume R, Felix T, Hariono S, Yu M, Berger MS, Huse JT, VandenBerg SR, James CD, Hodgson JG, Gupta N. Expression of miR-124 inhibits growth of medulloblastoma cells. Neuro Oncol. 2013 Jan;15(1):83-90. doi: 10.1093/neuonc/nos281. Epub 2012 Nov 21. PubMed PMID: 23172372; PubMed Central PMCID: PMC3534424.

Clark AJ, Cage TA, Aranda D, Parsa AT, Sun PP, Auguste KI, Gupta N. A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Childs Nerv Syst. 2013 Feb;29(2):231-8. doi: 10.1007/s00381-012-1926-2. Epub 2012 Oct 23. Review. PubMed PMID: 23089933.

Gupta N, Henry RG, Strober J, Kang SM, Lim DA, Bucci M, Caverzasi E, Gaetano L, Mandelli ML, Ryan T, Perry R, Farrell J, Jeremy RJ, Ulman M, Huhn SL, Barkovich AJ, Rowitch DH. Neural stem cell engraftment and myelination in the human brain. Sci Transl Med. 2012 Oct 10;4(155):155ra137. doi: 10.1126/scitranslmed.3004373. Erratum in: Sci Transl Med. 2012 Dec 19;4(165):165er8. PubMed PMID: 23052294; PubMed Central PMCID: PMC3893824.

Hashizume R, Smirnov I, Liu S, Phillips JJ, Hyer J, McKnight TR, Wendland M, Prados M, Banerjee A, Nicolaides T, Mueller S, James CD, Gupta N. Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment. J Neurooncol. 2012 Dec;110(3):305-13. doi: 10.1007/s11060-012-0973-6. Epub 2012 Sep 17. PubMed PMID: 22983601.

Clark AJ, Cage TA, Aranda D, Parsa AT, Auguste KI, Gupta N. Treatment-related morbidity and the management of pediatric craniopharyngioma: a systematic review. J Neurosurg Pediatr. 2012 Oct;10(4):293-301. doi: 10.3171/2012.7.PEDS11436. Epub 2012 Aug 24. Review. PubMed PMID: 22920295.

NS Adzick, EA Thom, CY Spong, JW Brock, PK Burrows, MP Johnson, LJ Howell, JA Farrell, ME Dabrowiak, LN Sutton, N Gupta, NB Tulipan, ME D’Alton, DL Farmer, MOMS Investigators. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med 364:993-1004, 2011

N Sanai, T Nguyen, RA Ihrie, Z Mirzadeh, H Tsai, M Wong, N Gupta, MS Berger, E Huang, J Garcia-Verdugo, DH Rowitch, A Alvarez-Buylla. Corridors of migratory neurons in human brain and their depletion during infancy. Nature 478:xxx, 2011

Hetts SW, Narvid J, Sanai N, Lawton MT, Gupta N, Fullerton HJ, Dowd CF, Higashida RT, Halbach VV. Intracranial Aneurysms in Childhood: 27-Year Single-Institution Experience. AJNR Am J Neuroradiol 30:1315-1324. 2009

McBride SM, Daganzo SM, Banerjee A, Gupta N, Lamborn KR, Prados MD, Berger MS, Wara WM, Haas-Kogan DA. Radiation is an Important Component of Multimodality Therapy for Pediatric Non-Pineal Supratentorial Primitive Neuroectodermal Tumors. Int J Radiat Oncol Biol Phys 73:1319-1323, 2008
 
Smith AB, Gupta N, Strober J, Chin C. Magnetic resonance neurography in children with birth-related brachial plexus injury. Pediatr Radiol 38(2):159-63, 2008 
 
Liang Y, Bollen AW, Gupta N. CC chemokine receptor-2A is frequently overexpressed in glioblastoma. J Neurooncol 86(2):153-63, 2008 
 
Liang Y, Diehn M, Bollen AW, Israel MA, Gupta N. Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment. J Neurooncol 86(2):133-41, 2008
 
Dinca EB, Sarkaria JN, Schroeder MA, Carlson BL, Voicu R, Gupta N, Berger MS, James CD. Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy. J Neurosurg 107(3):610-6, 2007
 
Wu Y, Green NL, Wrensch MR, Zhao S, Gupta N. Ventriculoperitoneal shunt complications in California: 1990 to 2000. Neurosurgery 61(3):557-62, 2007
 
Gupta N, Park J, Solomon C, Kranz DA, Wrensch M, Wu YW. Long-term outcomes in patients with treated childhood hydrocephalus. J Neurosurg 106(5 Suppl):334-9, 2007
 
Liang Y, Bollen AW, Aldape KD, Gupta N. Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma. BMC Cancer 6:97, 2006
 
Steinbok P, Garton HJ, Gupta N. Occult tethered cord syndrome: a survey of practice patterns. J Neurosurg 104(5 Suppl):309-13, 2006
 
Mishra KK, Puri DR, Missett BT, Lamborn KR, Prados MD, Berger MS, Banerjee A, Gupta N, Wara WM, Haas-Kogan DA. The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas. Neuro Oncol 8(2):166-74, 2006
 
Liang Y, Bollen AW, Nicholas MK, Gupta N. Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. BMC Clin Pathol 5:6, 2005