Nalin Gupta MD, PhD
Associate Professor in Residence of Neurological Surgery
Dennis Bruce Dettmer Endowed Chair in Pediatric Neurosurgery
Director, Pediatric Neurological Surgery Program
Principal Investigator, Brain Tumor Research Center
Director of the Department's Pediatric Neurological Surgery Program, Dr. Gupta has specialty interests in the evaluation and surgical management of neurological disorders in children, including such conditions as brain tumors, hydrocephalus, cranial and spinal congenital anomalies, and epilepsy. After his residency training in neurological surgery at the University of Toronto in Ontario, Canada, he completed fellowship training in pediatric neurosurgery at the Hospital for Sick Children in Toronto.
Dr.Gupta's research interests include fundamental mechanisms of brain tumor progression and defining the biological response of tumors to various treatment strategies. During his graduate studies, Dr. Gupta studied the effect of radiation and chemotherapy agents on glioma cells as they progress through the cell cycle.. Currently, his laboratory is focusing on cell-cell interactions during tumor progression, and the special role of pro-inflammatory cytokines. Dr. Gupta is also a member of the research group funded by the Pediatric Brain Tumor Foundation Institute Award. This program is directed towards basic and translational research for brainstem glioma and medulloblastoma.
Education, Training, and Previous Positions
- 1957: BS, University of Washington
1983: BS, McGill University, Montreal, Canada
1987: MD, University of Toronto, Canada
1987-1988: Surgical Internship, Mount Sinai Hospital, Faculty of Medicine, University of Toronto
1988-1989: Resident in Neurosurgery, University of Ottawa, Canada
1989-1997: Resident in Neurosurgery, Department of Neurosurgery, University of Toronto
1991-1996 Research Fellow, Medical Research Council of Canada and Brain Tumor Research Center, Department of Neurological Surgery, UCSF
1992-1996: PhD, Graduate Group in Biophysics, UCSF
1997-1998: Fellow in Pediatric Neurosurgery, Hospital for Sick Children, University of Toronto
1998-2000: Clinical Associate, Section of Neurosurgery, Department of Surgery, University of Chicago
Selected Professional Memberships and Appointments
- American Association of Cancer Research
American Association of Neurological Surgery
American Society of Pediatric Neurosurgeons
Congress of Neurological Surgeons
Joint Section on tumors, AANS/CNS
Joint Section on Pediatric Neurosurgery, AANS/CNS
Society of Neuro-Oncology
Selected Honors and Awards
- 1981: J.W. McConnell Scholarship, McGill University
1988: Outstanding Intern, Department of Emergency Medicine, Mount Sinai Hospital
1989: Resident Teaching Award, St. Michael's Hospital, Toronto
1994: Student Travel Award, Radiation Research Society
1995: Junior Scientist Travel Award, International Congress of Radiation Research
1995: T.P. Morley Resident Research Award, Division of Neurosurgery, University of Toronto
1997: Alan Hudson Resident Teaching Award, Division of Neurosurgery, University of Toronto
1997: Resident Teaching Award, St. Michael's Hospital, Toronto
2002: Hellman Family Award for Early Faculty, UCSF Cancer Center
2004: SPORE Career Development Award, Department of Neurological Surgery, UCSF
2005: NIH/NINDS K08 Career Development Award
Selected Recent Publications
Hetts SW, Narvid J, Sanai N, Lawton MT, Gupta N, Fullerton HJ, Dowd CF, Higashida RT, Halbach VV. Intracranial Aneurysms in Childhood: 27-Year Single-Institution Experience [published online ahead of print April 8, 2009]. AJNR Am J Neuroradiol. doi: 10.3174/ajnr.A1587
McBride SM, Daganzo SM, Banerjee A, Gupta N, Lamborn KR, Prados MD, Berger MS, Wara WM, Haas-Kogan DA. Radiation is an Important Component of Multimodality Therapy for Pediatric Non-Pineal Supratentorial Primitive Neuroectodermal Tumors [published online ahead of print May 15, 2008]. Int J Radiat Oncol Biol Phys. doi:10.1016/j.ijrobp.2008.03.033
Smith AB, Gupta N, Strober J, Chin C. Magnetic resonance neurography in children with birth-related brachial plexus injury. Pediatr Radiol 2008;38(2):159-63.
Liang Y, Bollen AW, Gupta N. CC chemokine receptor-2A is frequently overexpressed in glioblastoma. J Neurooncol 2008;86(2):153-63.
Liang Y, Diehn M, Bollen AW, Israel MA, Gupta N. Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment. J Neurooncol 2008;86(2):133-41.
Dinca EB, Sarkaria JN, Schroeder MA, Carlson BL, Voicu R, Gupta N, Berger MS, James CD. Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy. J Neurosurg 2007;107(3):610-6.
Wu Y, Green NL, Wrensch MR, Zhao S, Gupta N. Ventriculoperitoneal shunt complications in California: 1990 to 2000. Neurosurgery 2007;61(3):557-62.
Gupta N, Park J, Solomon C, Kranz DA, Wrensch M, Wu YW. Long-term outcomes in patients with treated childhood hydrocephalus. J Neurosurg 2007;106(5 Suppl):334-9.
Liang Y, Bollen AW, Aldape KD, Gupta N. Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma. BMC Cancer 2006;6:97.
Steinbok P, Garton HJ, Gupta N. Occult tethered cord syndrome: a survey of practice patterns. J Neurosurg 2006y;104(5 Suppl):309-13.
Mishra KK, Puri DR, Missett BT, Lamborn KR, Prados MD, Berger MS, Banerjee A, Gupta N, Wara WM, Haas-Kogan DA. The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas. Neuro Oncol 2006;8(2):166-74.
Liang Y, Bollen AW, Nicholas MK, Gupta N. Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. BMC Clin Pathol 2005;5:6.
Chi JH, Fullerton HJ, Gupta N. Time trends and demographics of deaths from congenital hydrocephalus in children in the United States: National Center for Health Statistics data, 1979 to 1998. J Neurosurg 2005;103(2 Suppl):113-8.