Pediatric Brain Tumor Clinical Trials
Questions about patients' participation in the following clinical trials can be directed to Dennis Aguiling by calling 415.353.9387 or by e-mail at AguilingD@peds.ucsf.edu. Alternatively, to contact the nurse practitioner in charge, please call 415.476.3831.
Newly Diagnosed Tumor
High-Grade Glioma
A Randomized Phase II/III Study of Vorinostat (IND# 71976) and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab and Local Irradiation Followed by Maintenance Bevacizumab (IND # 7921) and Temozolomide in Newly Diagnosed High Grade Glioma ( Children’s Oncology Group Study ACNS0822).Study Details
Ependymoma
Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years (Childrens Oncology Group Study ACNS0831). Study Details
Medulloblastoma and Primitive Neural Ectodermal Tumor (PNET)
A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy (18.00 Gy) and Chemotherapy in Children With Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial (Children's Oncology Group Study ACNS0331). Study Details.
Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients (Children's Oncology Group Study ACNS0332). Study Details.
A Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children < 36 Months Old with Intensive Induction Chemotherapy with Methotrexate Followed by Consolidation with Stem Cell Rescue vs. the Same Therapy Without Methotrexate (Children's Oncology Group Study ACNS0334). Study Details.
Atypicial Teratoid/Rhabdoid Tumor
Treatment of Atypical Teratoid/Rhabdoid Tumors of the Central Nervous System with Surgery, Intensive Chemotherapy, and 3-D Conformal Radiation (Children’s Oncology Group Study ACNS0333).
Recurrent Disease
A Phase I and Pharmacokinetic Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma (PBTC 029). This is a phase I study for children with recurrent and refractory low grade glioma. Study Details
A Phase I Pharmacokinetic Trial of PTC299 in Pediatric Patients with Refractory or Recurrent CNS Tumors (PBTC-031). This is a phase I study for children with recurrent or refractory tumors of the Central Nervous System.Study Details
A Phase II Clinical Trial Evaluating the Efficacy and Safety of GDC-0449 in Children with Recurrent or Refractory Medulloblastoma (PBTC-032) This is a Phase II trial for children with recurrent or refractory Medulloblastoma. Study Details
A Phase II Study of Bevacizumab and Lapatinib in Children with Recurrent or Refractory Ependymoma (CERN08-01). This is a phase II study for patients with recurrent or refractory ependymoma. Study Details.
A Phase I Study to Evaluate the Safety and Pharmacokinetics of Panitumumab in Children with Solid Tumors (Amgen Study 20050252). Study Details.
Temozolomide with Irinotecan Versus Temozolomide, Irinotecan plus Bevacizumab for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial (Children’s Oncology Group Trial ACNS0821). Study Details
A Phase 1 Study of Temsirolimus in Combination with Irinotecan and Temozolomide in Children, Adolescents, and Young Adults with Relapsed or Refractory Solid Tumors (Children’s Oncology Group Trial ADVL0918). Study Details
A Phase 1 Study of MK-2206, an AKT Inhibitor, in Pediatric Patients with Recurrent or Refractory Solid Tumors or Leukemia (Children’s Oncology Group Trial ADVL1013). Study Details
Pediatric Brain Tumor Clinical Trials In Development
A Phase 1/2 Study of Suberoylanilide Hydroxamic Acid (SAHA, Vorinostat) and Local Irradiation, Followed by Maintenance SAHA in Children with Newly Diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG) (Children’s Oncology Group Trial ACNS0927).
Trials Studying Late Effects of Treatment
Neurocognitive Brain Tumor Study. This is a prospective study to test the feasibility of a computerized neurocognitive training program in children with brain tumors. (This is a UCSF study).
Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer (Children's Oncology Group Trial ALTE07C1). Study Details