Ethan Winkler MD, PhD

Ethan Winkler MD

Expected Graduation: 2021





Education, Training, and Previous Positions

2006: BA, University of Southern California
2012: PhD, University of Rochester School of Medicine & Dentistry
2014: MD, University of Rochester School of Medicine & Dentistry

Selected Honors and Awards

2013: Alpha Omega Alpha Medical Honor Society
2013: Vincent du Vigneaud Award, University of Rochester School of Medicine & Dentistry
2012: Robert Doty Award of Excellence, University of Rochester School of Medicine & Dentistry
2009: Medical Scientist Training Program Award, University of Rochester School of Medicine & Dentistry
2009: Walle J. Nauta Adward for Excellence in Neural Science, University of Rochester School of Medicine & Dentistry
2008: McGraw-Hill/Lange Medical Student Award, University of Rochester School of Medicine & Dentistry
2007: Edward F. Adolph Medal for Excellence in Physiology, University of Rochester School of Medicine & Dentistry
2006: Renaissance Scholar, University of Southern California

Selected Recent Publications

Han SJ, Rutledge WC, Englot DJ, Winkler EA, Browne JL, Pflugrath L, Cronsier D, Abla AA, Kliot M, Lawton MT. The Presto 1000: A novel automated transcranial Doppler ultrasound system. J Clin Neurosci. 2015 Jul 31. pii: S0967-5868(15)00290-8.

Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 Jul;18(7):978-87.

Yue JK, Winkler EA, McAllister TW, Temkin N, Ferguson A, Lingsma HF, Yuh E, Tarapore PE, Sharma S, Puccio A, Wang K, Mukherjee P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley GT. 178 COMT Val158Met is Associated With Domain-Specific Cognitive Impairment Following Mild Traumatic Brain Injury. Neurosurgery. 2015 Aug;62 Suppl 1:225.

Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, Zlokovic BV. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab. 2015 Mar 11. doi: 10.1038/jcbfm.2015.44. [Epub ahead of print].

Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci 2015;18(4):521-30.

Yue JK, Pronger AM, Ferguson AR, Temkin NR, Sharma S, Rosand J, Sorani MD, McAllister TW, Barber J, Winkler EA, Burchard EG, Hu D, Lingsma HF, Cooper SR, Puccio AM, Okonkwo DO, Diaz-Arrastia R, Manley GT; COBRIT Investigators; TRACK-TBI Investigators. Association of a common genetic variant within ANKK1 with six-month cognitive performance after traumatic brain injury. Neurogenetics 2015;16(3):169-80.

Winkler EA, Sagare AP, Zlokovic BV. The pericyte: a forgotten cell type with important implications for Alzheimer’s disease? Brain Pathol 2014;24(4):371-86.

Winkler EA
, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. Blood-spinal cord barrier disruption contributes to early motor neuron degeneration in ALS model mice. Proc Natl Acad Sci USA 2014;111(11):E1035-42.

Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun 2013;4:2932.

Sengillo JD, Winkler EA, Walker CT, Sullivan JS, Johnson M, Zlokovic BV. Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer’s disease. Brain Pathol 2013;23(3):303-10.

Winkler EA, Sengillo JD, Sullivan JS, Henkel JS, Appel SH, Zlokovic BV. Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. Acta Neuropathol 2013;125(1):111-20.

Winkler EA, Sengillo JD, Bell RD, Wang J, Zlokovic BV. Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. J Cereb Blood Flow Metab 2012;32(10):1841-52.

Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 2012;485(7399):512-6.

Petraglia AL, Winkler EA, Bailes JE. Stuck at the bench: potential natural neuroprotective compounds for concussion. Surg Neurol Int 2011;2:146. Winkler EA, Bell RD, Zlokovic BV. Central nervous system pericytes in health and disease. Nat Neurosci 2011;14(11):1398-405.

Sagare AP, Winkler EA, Bell RD, Deane R, Zlokovic BV. From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels. J Neurosci Res 2011;89(7):967-8.

Zhong Z, Winkler EA, Zlokovic BV. Microhemorrhages: undetectable but clinically meaningful the question persists. Amyotroph Lateral Scler 2011;12(3):231-2.

Winkler EA, Bell RD, Zlokovic BV. Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch. Dev Cell 2011;20(3):409-427.

Bell RD, Winkler EA, Sagare AP, Singh I, Larue B, Deane R, Zlokovic BV. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 2010;68(3):409-427.

Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain. J Neurochem 2010;115(5), 1077-89.

Winkler EA, Bell RD, Zlokovic BV (2010). Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Mol Neurodegener 2010;5:32.

Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosinge 1-phosphate receptor. Blood 2010;115(23):4963-72.

Hudak LM, Lunt S, Chang CH, Winkler E, Flammer H, Lindsey M, Perkins BD. The intraflagellar transport protein ift80 is essential for photoreceptor survival in a zebrafish model of jeune asphyxiating thoracic dystrophy. Invest Ophthalmol Vis Sci 2010;51(7):3792-99.