John K. Wiencke PhD

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Professor in Residence of Neurological Surgery and Epidemiology and Biostatistics

Co-Director, Division of Neuroepidemiology

 

 


Dr. Wiencke's background is in cytogenetics, radiation biology, and molecular epidemiology. His research has focused on biomarkers of exposure to chemical toxins and tobacco smoke and on genetic susceptibility to environmental exposures. Wiencke is the director of the laboratory providing support for epidemiological and clinical studies in neuroepidemiology. His laboratory is currently studying molecular subgroups of glioma and aberrant gene methylation.

Education, Training, and Previous Positions

1976: BS, University of Minnesota, Minneapolis
1978: MS, University of Minnesota, Minneapolis
1983: PhD, University of Minnesota, Minneapolis
1983-1986: Postdoctoral Fellow, Laboratory of Radiobiology and Environmental Health, UCSF
1986-1989: Assistant Research Geneticist, Department of Epidemiology and Biostatistics, UCSF
1986-1995: Research Associate, Laboratory of Radiobiology and Environmental Health, UCSF
1990-1993: Assistant Adjunct Professor, Department of Epidemiology and Biostatistics, UCSF
1990-2004: Director, Molecular Epidemiology Lab, Department of Epidemiology and Biostatistics, UCSF
1993-1999: Associate Adjunct Professor, Department of Epidemiology and Biostatistics, UCSF
1995-2004: Director, Molecular Epidemiology Program, Department of Epidemiology and Biostatistics, UCSF
1999-2002: Adjunct Professor, Department of Epidemiology and Biostatistics, UCSF
2002-2004: Professor In Residence (Joint Appointment Current), Department of Epidemiology and Biostatistics, UCSF

Selected Professional Memberships and Appointments

American Association for Cancer Research
American Society of Human Genetics
Environmental Health Institute

Selected Honors and Awards

1983: Bacaner Basic Science Award, University of Minnesota

Selected Recent Publications

Wiencke JK, Zheng S, Morrison Z, Yeh RF. Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells. Oncogene 2007; [Epub ahead of print].
 
Felini MJ, Olshan AF, Schroeder JC, North KE, Carozza SE, Kelsey KT, Liu M, Rice T, Wiencke JK, Wrensch MR. DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas. Neuroepidemiology 2007;29(1-2):55-8.
 
Hansen HM, Wiemels JL, Wrensch M, Wiencke JK. DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platform. Cancer Epidemiol Biomarkers Prev 2007;16(8):1686-90.
 
Wiemels JL, Wiencke JK, Kelsey KT, Moghadassi M, Rice T, Urayama KY, Miike R, Wrensch M. Allergy-related polymorphisms influence glioma status and serum IgE levels. Cancer Epidemiol Biomarkers Prev 2007;16(6):1229-35.
 
Wiencke JK, Zheng S, Jelluma N, Tihan T, Vandenberg S, Tamguney T, Baumber R, Parsons R, Lamborn KR, Berger MS, Wrensch MR, Haas-Kogan DA, Stokoe D. Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neuro Oncol 2007;9(3):271-9.
 
Wrensch M, McMillan A, Wiencke J, Wiemels J, Kelsey K, Patoka J, Jones H, Carlton V, Miike R, Sison J, Moghadassi M, Prados M. Nonsynonymous coding single-nucleotide polymorphisms spanning the genome in relation to glioblastoma survival and age at diagnosis. Clin Cancer Res 2007;13(1):197-205.
 
Urayama KY, Wiencke JK, Buffler PA, Chokkalingam AP, Metayer C, Wiemels JL. MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev 2007;16(6):1172-7.
 
Yong LC, Schulte PA, Kao CY, Giese RW, Boeniger MF, Strauss GH, Petersen MR, Wiencke JK. DNA adducts in granulocytes of hospital workers exposed to ethylene oxide. Am J Ind Med 2007;50(4):293-302.
 
Wrensch M, Wiencke JK, Wiemels J, Miike R, Patoka J, Moghadassi M, McMillan A, Kelsey KT, Aldape K, Lamborn KR, Parsa AT, Sison JD, Prados MD. Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival. Cancer Res 2006;66(8):4531-41.
 
Wrensch M, Kelsey KT, Liu M, Miike R, Moghadassi M, Sison JD, Aldape K, McMillan A, Wiemels J, Wiencke JK. ERCC1 and ERCC2 polymorphisms and adult glioma. Neuro Oncol 2005;7(4):495-507.
 
Tang J, Shao W, Dorak MT, Li Y, Miike R, Lobashevsky E, Wiencke JK, Wrensch M, Kaslow RA, Cobbs CS. Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme. Cancer Epidemiol Biomarkers Prev 2005;14(8):2040-4.
 
Wiencke JK, Aldape K, McMillan A, Wiemels J, Moghadassi M, Miike R, Kelsey KT, Patoka J, Long J, Wrensch M. Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase. Cancer Epidemiol Biomarkers Prev 2005;14(7):1774-83.
 
Wrensch M, Kelsey KT, Liu M, Miike R, Moghadassi M, Aldape K, McMillan A, Wiencke JK. Glutathione-S-transferase variants and adult glioma. Cancer Epidemiol Biomarkers Prev 2004;13:461-7.