Philip R. Weinstein MD
Professor of Neurological Surgery
Dr. Weinstein specializes in the treatment of adult disc disease, adult spinal deformities and spondylolisthesis, spinal stenosis, complex spinal instrumentation, degenerative neurospinal disorders, spinal axis tumors, spinal cord vascular malformations, and spinal trauma or instability.
Dr. Weinstein's research has chiefly concerned repair and regeneration after spinal cord injury, the cerebrovascular, cardiovascular, and metabolic aspects of cerebral ischemia, and mechanisms of brain protection during temporary focal ischemia and reperfusion. He has used advanced magnetic resonance imaging techniques in the study of diffusion and perfusion and spectroscopic imaging to detect thresholds of viability. More recently, he has become involved in molecular biologic approaches to mechanisms of ischemic neuronal injury in the brain and spinal cord and the study of impairment of blood flow regulation.
Education, Training, and Previous Positions
- 1961: BA, Princeton University
1965: MD, New York University College of Medicine
1965-1966: Internship, UCSF
1966-1971: Residency in Neurological Surgery, UCSF
1971-1973: Attending Neurosurgeon, Loma Linda University Medical Center
1973-1977: Assistant Professor, Neurological Surgery, UCSF
1977-1981: Associate Professor, Neurological Surgery, University of Arizona Health Sciences Center
1980-1982: Professor, Neurological Surgery, University of Arizona Health Sciences Center
1982-1984: Associate Professor, Neurological Surgery, UCSF
1984-present: Professor, Neurological Surgery, UCSF
Selected Honors and Awards
- 1995 - 20009: Chairman, Resident Matching Committee, The Society of Neurological Surgeons
2005: President, The Society of Neurological Surgeons
2003: Vice-President, The Society of Neurological Surgeons
2007 - 2008: Vice President, Western Neurosurgical Society
Selected Recent Publications
Yuh EL, Jain Palrecha S, Lagemann GM, Kliot M, Weinstein PR, Barbaro NM, Chin
CT. Diffusivity Measurements Differentiate Benign from Malignant Lesions in
Patients with Peripheral Neuropathy or Plexopathy. AJNR Am J Neuroradiol. 2014
Oct 9. [Epub ahead of print] PubMed PMID: 25300985.
Safaee M, Oh MC, Mummaneni PV, Weinstein PR, Ames CP, Chou D, Berger MS, Parsa AT, Gupta N. Surgical outcomes in spinal cord ependymomas and the importance of extent of resection in children and young adults. J Neurosurg Pediatr 2014;13(4):393-9.
Clark AJ, Ziewacz JE, Safaee M, Lau D, Lyon R, Chou D, Weinstein PR, Ames CP, Clark JP 3rd, Mummaneni PV. Intraoperative neuromonitoring with MEPs and prediction of postoperative neurological deficits in patients undergoing surgery for cervical and cervicothoracic myelopathy. Neurosurg Focus 2013;35(1):E7.
Tarapore PE, Modera P, Naujokas A, Oh MC, Amin B, Tihan T, Parsa AT, Ames CP, Chou D, Mummaneni PV, Weinstein PR. Pathology of spinal ependymomas: an institutional experience over 25 years in 134 patients. Neurosurgery 2013;73(2):247-55.
Abdul-Jabbar A, Takemoto S, Weber MH, Hu SS, Mummaneni PV, Deviren V, Ames CP, Chou D, Weinstein PR, Burch S, Berven SH. Surgical site infection in spinal surgery: description of surgical and patient-based risk factors for postoperative infection using administrative claims data. Spine (Phila Pa 1976) 2012;37(15):1340-5.
Clark AJ, Lu DC, Richardson RM, Tihan T, Parsa AT, Chou D, Barbaro NM, Kunwar S, Weinstein PR, Lawton MT, Berger MS, McDermott MW. Surgical technique of temporary arterial occlusion in the operative management of spinal hemangioblastomas. World Neurosurg 2010;74(1):200-5.
Du R, Auguste KI, Chin CT, Engstrom JW, Weinstein PR. Magnetic resonance neurography for the evaluation of peripheral nerve, brachial plexus, and nerve root disorders J Neurosurg 2010;112(2):362-71.
Wang Y, Bontempi B, Hong SM, Mehta K, Weinstein PR , Abrams GM, Liu J. A comprehensive analysis of gait impairment after experimental stroke and the therapeutic effect of environmental enrichment in rats. J Cereb Blood Flow Metab 2008;28(12):1936-50.
Acosta FL Jr, Sanai N, Chi JH, Dowd CF, Chin C, Tihan T, Chou D, Weinstein PR, Ames CP. Comprehensive management of symptomatic and aggressive vertebral hemangiomas. Neurosurg Clin N Am 2008;19(1):17-29.
Hong SM, Liu Z, Fan Y, Neumann M, Won SJ, Lac D, Lum X, Weinstein PR, Liu J. Reduced hippocampal neurogenesis and skill reaching performance in adult Emx1 mutant mice. Exp Neurol 2007;206(1):24-32.
Fan Y, Liu Z, Weinstein PR, Fike JR, Liu J. Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation. Eur J Neurosci 2007;25(1):38-46.
Liu Z, Fan Y, Won SJ, Neumann M, Hu D, Zhou L, Weinstein PR, Liu J. Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia. Stroke 2007;38(1):146-52.
Quinones-Hinojosa A, Robert Kolen E, Jun P, Rosenberg WS, Weinstein PR. Accuracy over space and time of computer-assisted fluoroscopic navigation in the lumbar spine in vivo. J Spinal Disord Tech 2006;19(2):109-13.
Acosta FL Jr, Dowd CF, Chin C, Tihan T, Ames CP, Weinstein PR. Current treatment strategies and outcomes in the management of symptomatic vertebral hemangiomas. Neurosurgery 2006;58(2):287-95; discussion 287-95.
Guo L, Quinones-Hinojosa A, Yingling CD, Weinstein PR. Continuous EMG recordings and intraoperative electrical stimulation for identification and protection of cervical nerve roots during foraminal tumor surgery. J Spinal Disord Tech 2006;19(1):37-42.
Matsumori Y, Northington FJ, Hong SM, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J. Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70. Stroke 2006;37(2):507-12.
Matsumori Y, Hong SM, Fan Y, Kayama T, Hsu CY, Weinstein PR, Liu J. Enriched environment and spatial learning enhance hippocampal neurogenesis and salvages ischemic penumbra after focal cerebral ischemia. Neurobiol Dis 2006;22(1):187-98.
Binder DK, Sarkissian V, Dillon WP, Weinstein PR. Spontaneous intracranial hypotension associated with transdural thoracic osteophyte reversed by primary dural repair [Case report]. J Neurosurg Spine 2005;2(5):614-8.
Acosta FL Jr, Thompson TL, Campbell S, Weinstein PR, Ames CP. Use of intraoperative isocentric C-arm 3D fluoroscopy for sextant percutaneous pedicle screw placement: case report and review of the literature. Spine J 2005;5(3):339-43.
Quinones-Hinojosa A, Lyon R, Zada G, Lamborn KR, Gupta N, Parsa AT, McDermott MW, Weinstein PR. Changes in transcranial motor evoked potentials during intramedullary spinal cord tumor resection correlate with postoperative motor function. Neurosurgery 2005;56(5):982-93; discussion 982-93.
Matsumori Y, Hong SM, Aoyama K, Fan Y, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J. Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J Cereb Blood Flow Metab 2005;25(7):899-910.
Suh SW, Fan Y, Hong SM, Liu Z, Matsumori Y, Weinstein PR, Swanson RA, Liu J. Hypoglycemia induces transient neurogenesis and subsequent progenitor cell loss in the rat hippocampus. Diabetes 2005;54(2):500-9.