Philip Theodosopoulos MD

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Professor and Vice Chair of Neurological Surgery

Reza and Georgianna Khatib Endowed Chair in Skull Base Surgery

Director, Skull Base Tumor Program

Co-Director, Skull Base and Cerebrovascular Laboratory

 

Dr. Theodosopoulos is the Director of Skull Base Tumor Program and a Professor and Vice Chairman of neurological surgery at UCSF. Before joining the faculty at UCSF, he served as the Residency Program Director and the Director of Skull Base Surgery at the University of Cincinnati for 10 years. Dr. Theodosopoulos completed his undergraduate work at MIT and medical school at Stanford University. He completed his neurosurgical training at UCSF and a fellowship in cerebrovascular and skull base surgery at the Brigham and Women’s Hospital, Harvard University.

Dr. Theodosopoulos' primary clinical interests involve the treatment of skull base lesions, particularly acoustic neuromas and malignancies as well as minimally invasive approaches to the skull base. He served as the Co-Principal Investigator for the largest prospective multi-center trial of the surgical treatment of acoustic neuromas and currently serves on the Medical Advisory Board of the Acoustic Neuroma Association. He has extensive expertise in the endoscopic treatment of pituitary adenomas and chordomas and has been a pioneer in the development of new surgical approaches to the skull base. As the do-director of the Goodyear Microsurgical Laboratory at the University of Cincinnati he lead a prolific team focused on translational work related to the development of novel surgical corridors to the skull base among which the first description and clinical application of the endoscopic approach to the infratemporal fossa.

He has been faculty on more than 50 national and international surgical courses and serves on the Congress of Neurological Surgeons Education Committee. Dr Theodosopoulos also has extensive expertise in the field of Outcomes Research having completed the UCSF Outcome Research and Clinical Epidemiology full curriculum as a resident and having remained involved in outcomes research at the local and national level.

Education, Training, and Previous Positions

1992: BS, Massachusetts Institute of Technology
1996: MD, Stanford University School of Medicine
1998: Outcomes Research And Clinical Epidemiology (ORACLE),UCSF Department of Epidemiology and Biostatistics
1996-1997: Internship, General Surgery, UCSF
1997-2002: Residency in Neurosurgery, UCSF
2002-2003: Fellowship in Cerebrovascular and Skull Base Surgery, Brigham and Women's and Children's Hospital
2003-2013: Director, Division of Skull Base Surgery, Department of Neurosurgery, University of Cincinnati
2003-2013: Clinical Director, Goodyear Microsurgery Laboratory, Departments of Neurosurgery and ENT, University of Cincinnati
2003-2013: Director, Skull Base Surgery Fellowship, Department of Neurosurgery, University of Cincinnati
2003-2009: Assistant Professor, Department of Neurosurgery, University of Cincinnati
2008-2013: Director, Neurosurgery Residency Program, Department of Neurosurgery, University of Cincinnati
2009-2013: Associate Professor, Department of Neurosurgery, University of Cincinnati

Selected Professional Memberships and Appointments

Society of Neurological Surgeons 
Society of University Neurosurgeons
Congress of Neurological Surgeons
American Association of Neurological Surgeons
European Association of Neurosurgical Societies
International Stereotactic Radiosurgery Society
AANS/CNS Joint Section on Tumors
AANS/CNS Joint Section on Neurotrauma and Critical Care
California Association of Neurological Surgeons
North American Skull Base Society
Pituitary Network Association
Acoustic Neuroma Association

Selected Honors and Awards

2013: Visiting Lecturer, Department of Neurosurgery, Baylor School of
Medicine, Houston, TX 2010: Khatib Lecturer and Visiting Professor, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA
2006: Franklin M. Rizer Lecturer, American Neuro-otology Society, Fall Scientific Meeting, Toronto, Canada
1997: Honorable mention for outstanding teaching in surgical core clerkship UCSF, Department of Surgery
1996: Dean’s award for Distinguished Research in Neurobiology, Stanford University School of Medicine
1993: Hellenic Medical and Dental Association award for excellence in the Health Sciences
1993: Medical Scholars scholarship, Stanford University School of Medicine

Selected Recent Publications

Magill ST, Lee DS, Yen AJ, Lucas CG, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW. Surgical outcomes after reoperation for recurrent skull base meningiomas. J Neurosurg. 2018 May 4:1-8. doi: 10.3171/2017.11.JNS172278. [Epub ahead of print] PubMed PMID: 29726777.

Magill ST, Rick JW, Chen WC, Haase DA, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW. Petrous Face Meningiomas: Classification, Clinical Syndromes, and Surgical Outcomes. World Neurosurg. 2018 Apr 4. pii: S1878-8750(18)30676-4. doi: 10.1016/j.wneu.2018.03.194. [Epub ahead of print] PubMed PMID: 29626689.

Chen WC, Magill ST, Wu A, Vasudevan HN, Morin O, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Braunstein SE, Raleigh DR. Histopathological features predictive of local control of atypical meningioma after surgery and adjuvant radiotherapy. J Neurosurg. 2018 Apr 6:1-8. doi: 10.3171/2017.9.JNS171609. [Epub ahead of print] PubMed PMID: 29624151.

Magill ST, Young JS, Chae R, Aghi MK, Theodosopoulos PV, McDermott MW. Relationship between tumor location, size, and WHO grade in meningioma. Neurosurg Focus. 2018 Apr;44(4):E4. doi: 10.3171/2018.1.FOCUS17752. PubMed PMID: 29606048.

Magill ST, Morshed RA, Lucas CG, Aghi MK, Theodosopoulos PV, Berger MS, de Divitiis O, Solari D, Cappabianca P, Cavallo LM, McDermott MW. Tuberculum sellae meningiomas: grading scale to assess surgical outcomes using the transcranial versus transsphenoidal approach. Neurosurg Focus. 2018 Apr;44(4):E9. doi: 10.3171/2018.1.FOCUS17753. PubMed PMID: 29606045.

Breshears JD, Chang J, Molinaro AM, Sneed PK, McDermott MW, Tward A, Theodosopoulos PV. Temporal Dynamics of Pseudoprogression After Gamma Knife Radiosurgery for Vestibular Schwannomas-A Retrospective Volumetric Study. Neurosurgery. 2018 Mar 5. doi: 10.1093/neuros/nyy019. [Epub ahead of print] PubMed PMID: 29518221.

Chen WC, Hara J, Magill ST, Wu A, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Raleigh DR, Braunstein SE. Salvage therapy outcomes for atypical meningioma. J Neurooncol. 2018 Jun;138(2):425-433. doi: 10.1007/s11060-018-2813-9. Epub 2018 Feb 26. PubMed PMID: 29480505.

Yu Y, El-Sayed IH, McDermott MW, Theodosopoulos PV, van Zante A, Kased N, Glastonbury CM, Garsa AA, Yom SS. Dural recurrence among esthesioneuroblastoma patients presenting with intracranial extension. Laryngoscope. 2018 Feb 10. doi: 10.1002/lary.27126. [Epub ahead of print] PubMed PMID: 29427378.

Wu A, Garcia MA, Magill ST, Chen W, Vasudevan HN, Perry A, Theodosopoulos PV, McDermott MW, Braunstein SE, Raleigh DR. Presenting Symptoms and Prognostic Factors for Symptomatic Outcomes Following Resection of Meningioma. World Neurosurg. 2018 Mar;111:e149-e159. doi: 10.1016/j.wneu.2017.12.012. Epub 2017 Dec 14. PubMed PMID: 29248774.

Byer L, Rutledge C, Wallender E, Osorio JA, Jacobs R, Theodosopoulos PV. Salmonella Infection After Craniotomy. Cureus. 2017 Aug 15;9(8):e1566. doi: 10.7759/cureus.1566. PubMed PMID: 29057178; PubMed Central PMCID: PMC5640389.

Paulsson AK, Braunstein S, Phillips J, Theodosopoulos PV, McDermott M, Sneed PK, Ma L. Patient-Specific Fetal Dose Determination for Multi-Target Gamma Knife Radiosurgery: Computational Model and Case Report. Cureus. 2017 Jul 31;9(7):e1527. doi: 10.7759/cureus.1527. PubMed PMID: 28975062; PubMed Central PMCID: PMC5621780.

Breshears JD, Osorio JA, Cheung SW, Barani IJ, Theodosopoulos PV. Surgery After Primary Radiation Treatment for Sporadic Vestibular Schwannomas: Case Series. Oper Neurosurg (Hagerstown). 2017 Aug 1;13(4):441-447. doi: 10.1093/ons/opx023. PubMed PMID: 28838116.

Vasudevan HN, Raleigh DR, Johnson J, Garsa AA, Theodosopoulos PV, Aghi MK, Ames C, McDermott MW, Barani IJ, Braunstein SE. Management of Chordoma and Chondrosarcoma with Fractionated Stereotactic Radiotherapy. Front Surg. 2017 Jun 23;4:35. doi: 10.3389/fsurg.2017.00035. eCollection 2017. PubMed PMID: 28691010; PubMed Central PMCID: PMC5481320.

Safaee MM, McDermott MW, Benet A, Theodosopoulos PV. Tailored Extended Bifrontal Craniotomy for Anterior Skull Base Tumors: Anatomic Description of a Modified Surgical Technique and Case Series. Oper Neurosurg (Hagerstown). 2018 Apr 1;14(4):386-394. doi: 10.1093/ons/opx134. PubMed PMID: 28541579.

Magill ST, Theodosopoulos PV, McDermott MW. Resection of falx and parasagittal meningioma: complication avoidance. J Neurooncol. 2016 Nov;130(2):253-262. Epub 2016 Oct 24. Review. PubMed PMID: 27778211.

Ma L, Braunstein SE, Theodosopoulos PV, McDermott MW, Sneed PK. Inherent functional dependence among cochlear dose surrogates for stereotactic radiosurgery of vestibular schwannomas. Pract Radiat Oncol. 2017 Jan - Feb;7(1):e1-e7. doi: 10.1016/j.prro.2016.08.005. Epub 2016 Aug 20. PubMed PMID: 27742557.

Chiu J, Pierce M, Braunstein SE, Theodosopoulos PV, McDermott MW, Sneed PK, Ma L. Sharpening peripheral dose gradient via beam number enhancement from patient head tilt for stereotactic brain radiosurgery. Phys Med Biol. 2016 Oct 3;61(20):N532-N541. [Epub ahead of print] PubMed PMID: 27694708.

Theodosopoulos PV, Cebula H, Kurbanov A, Cabero AB, Osorio JA, Zimmer LA, Froelich SC, Keller JT. The Medial Extra-Sellar Corridor to the Cavernous Sinus: Anatomic Description and Clinical Correlation. World Neurosurg. 2016 Dec;96:417-422. doi: 10.1016/j.wneu.2016.09.046. Epub 2016 Sep 19. PubMed PMID: 27659813.

Han SJ, Reis G, Kohanbash G, Shrivastav S, Magill ST, Molinaro AM, McDermott MW, Theodosopoulos PV, Aghi MK, Berger MS, Butowski NA, Barani I, Phillips JJ, Perry A, Okada H. Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma. J Neurooncol. 2016 Dec;130(3):543-552. Epub 2016 Sep 13. PubMed PMID: 27624915; PubMed Central PMCID: PMC5560602.

Raleigh DR, Seymour ZA, Tomlin B, Theodosopoulos PV, Berger MS, Aghi MK, Geneser SE, Krishnamurthy D, Fogh SE, Sneed PK, McDermott MW. Resection and brain brachytherapy with permanent iodine-125 sources for brain metastasis. J Neurosurg. 2017 Jun;126(6):1749-1755. doi: 10.3171/2016.4.JNS152530. Epub 2016 Jul 1. PubMed PMID: 27367240.

Anaizi AN, DiNapoli VV, Pensak M, Theodosopoulos PV. Small Vestibular Schwannomas: Does Surgery Remain a Viable Treatment Option? J Neurol Surg B Skull Base. 2016 Jun;77(3):212-8. doi: 10.1055/s-0035-1564591. Epub 2015 Oct 8. PubMed PMID: 27175315; PubMed Central PMCID: PMC4862868.

Safaee MM, Blevins L, Liverman CS, Theodosopoulos PV. Abscess Formation in a Nonfunctioning Pituitary Adenoma. World Neurosurg. 2016 Jun;90:703.e15-703.e18. doi: 10.1016/j.wneu.2016.02.090. Epub 2016 Mar 2. PubMed PMID: 26944883.

Birk HS, Han SJ, Rolston JD, Rowland NC, Lau C, Theodosopoulos PV, McDermott MW. Resident-led Implementation of a Standardized Handoff System to Facilitate Transfer of Postoperative Neurosurgical Patients to the ICU. Cureus. 2016 Jan 18;8(1):e461. doi: 10.7759/cureus.461. PubMed PMID: 26929888; PubMed Central PMCID: PMC4762767.

Monfared A, Corrales CE, Theodosopoulos PV, Blevins NH, Oghalai JS, Selesnick SH, Lee H, Gurgel RK, Hansen MR, Nelson RF, Gantz BJ, Kutz JW Jr, Isaacson B, Roland PS, Amdur R, Jackler RK. Facial Nerve Outcome and Tumor Control Rate as a Function of Degree of Resection in Treatment of Large Acoustic Neuromas: Preliminary Report of the Acoustic Neuroma Subtotal Resection Study (ANSRS). Neurosurgery. 2016 Aug;79(2):194-203. doi: 10.1227/NEU.0000000000001162. PubMed PMID: 26645964.