Marco Sorani, PhD


Adjunct Assistant Professor of Neurological Surgery

Senior Manager, Genentech, Inc.

Dr. Sorani is a Senior Manager at Genentech, Inc. and an Adjunct Assistant Professor in the Department of Neurosurgery at UCSF. His research areas include biomarker discovery, outcomes research, clinical trials, computational characterization of genetic variation and gene expression, systems biology, and pharmacogenomics. His focus areas include the analysis of large data sets of genetic, gene expression, protein and clinical biomarkers in neurotrauma and neurodegenerative diseases. He has also developed database infrastructure and operational processes to support integrated biomarker discovery and has functioned as a liaison between clinical, experimental and informatics communities.

Previously, Dr. Sorani worked as an informatics professional with expertise in computational biology research and consulting, as well as software entrepreneurship, development, and project management. He was co-founder and vice president of product management at SSB Technologies, Inc. as well as a senior information technology manager at Oracle Corporation. He began his career as a management consultant at Ernst & Young and Andersen Consulting (now Accenture). He holds a B.S.E. in Operations Research from Princeton University and a Ph.D. in Biological & Medical Informatics from the University of California, San Francisco, where he trained under co-advisors Dr. Geoffrey Manley and Dr. Kathleen Giacomini and investigated the role of genetic variation in aquaporin-4 on physiological and therapeutic response after brain injury. As a graduate student, he was also the recipient of an NIH (NINDS) Kirchstein pre-doctoral fellowship and an American Society for Clinical Pharmacology and Therapeutics presidential trainee award.

Education, Training, and Previous Positions

1991: BS, Princeton University
1991-1994: Systems Integration Consultant, Andersen Consulting
1994-1996: Senior Management Consultant, Ernst & Yound
1996-2000: Senior IT Manager, Oracle Corporation
2000-2002: Co-founder, VIP of Product Management, SSB Technologies
2002-2005: Bioinformatics Consultant
2007-2010: Computational Biologist, Immunology Diagnostics, Genentech Inc.
2010-2013: Senior Manager, Market Analysis & Strategy, Genentech Inc.
2013-present: Senior Manager, Pipeline & Portfolio Planning, Genentech Inc.

Selected Honors and Awards

2009: Genentech Development organization's Innovation Award
2006: American Society for Clinical Pharmacology and Therapeutics Presidential Trainee Award
2005: Dean's Award for Excellence in Teaching as T.A. to Prof. Patricia Babbitt for BPS114, UCSF
2005: Recipient of a UCSF Graduate Student Association Research Award
2004: Recipient of an NRSA\NIH (NINDS) Kirchstein Pre-doctoral Fellowship
2004: Recipient of the 2004 Genentech Scholars Program Graduate Fellowship
2001: Forbes Magazine “Best of the Web”
2001: Federal Computer Week Magazine “10 Companies to Watch”

Selected Recent Publications

Sorani MD, Zador Z, Hurowitz E, Yan D, Giacomini KM, Manley GT. Novel variants in human Aquaporin-4 reduce cellular water permeability. Hum Mol Genet 2008;17(15):2379-89.

Rosenthal G, Hemphill JC 3rd, Sorani M, Martin C, Morabito D, Obrist WD, Manley GT. Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Crit Care Med 2008;36(6):1917-24.

Sorani MD, Manley GT, Giacomini KM. Genetic variation in human aquaporins and effects on phenotypes of water homeostasis [Review]. Hum Mutat 2008;29(9):1108-17.

Sorani MD, Morabito D, Rosenthal G, Giacomini KM, Manley GT. Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system. J Neurotrauma 2008;25(4):291-8.

Sorani MD, Manley GT. Dose-response relationship of mannitol and intracranial pressure: a metaanalysis. J Neurosurg 2008;108(1):80-7. Rosenthal G, Hemphill JC, Sorani M, Martin C, Morabito D, Meeker M, Wang V, Manley GT. The role of lung function in brain tissue oxygenation following traumatic brain injury. J Neurosurg 2008;108(1):59-65.

Sorani MD, Hemphill JC 3rd, Morabito D, Rosenthal G, Manley GT. New approaches to physiological informatics in neurocritical care. Neurocrit Care 2007;7(1):45-52.

Chen Y, Zhang S, Sorani M, Giacomini KM. Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. J Pharmacol Exp Ther 2007;322(2):695-700.

Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network. Pharmacol Rev 2006;58(1):5-6.

Berlin A, Sorani M, Sim I. A taxonomic description of computer-based clinical decision support systems. J Biomed Inform 2006;39(6):656-67.

Berlin A, Sorani M, Sim I. Characteristics of outpatient clinical decision support systems: a taxonomic description. Stud Health Technol Inform 2004;107(Pt 1):578-81.