Corey Raffel MD, PhD

Professor of Clinical Neurological Surgery 

 

Dr. Corey Raffel is a board-certified pediatric neurosurgeon and leads UCSF's pediatric neurosurgery outreach service at Good Samaritan Hospital in San Jose, CA. Dr. Raffel joined UCSF from Ohio State University, where he served as professor and vice chair. He has also served as chief of pediatric neurosurgery at Nationwide Children’s Hospital and been the principal investigator of several research programs aimed at finding new treatments for childhood brain tumors. He is currently the surgical PI of a clinical trial evaluating an oncolytic measles vaccine for recurrent medulloblastoma or atypical teratoid/rhabdoid tumor. 

At Good Samaritan Hospital, Dr. Raffel brings his outstanding expertise in diagnosis and surgical management of pediatric neurosurgical disorders to the community surrounding San Jose. He is available for consultation or referrals regarding all types of pediatric neurological disorders.

Education, Training, and Previous Positions

1974: AB, Harvard University
1980: MD, University of California, San Diego
1980: PhD, University of California, San Diego
1980-1986: Resident, Department of Neurological Surgery, UCSF
1986: Pediatric Neurosurgery Fellow, Hospital for Sick Kids, Toronto
1987: Pediatric Neurosurgery Fellow, UCSF
1987: Clinical Instructor, Department of Neurological Surgery, UCSF
1987-1992: Assistant Professor of Neurological Surgery, University of Southern California School of Medicine, Los Angeles, CA
1992-1995: Associate Professor of Neurological Surgery, University of Southern California School of Medicine, Los Angeles, CA
1996-1999: Associate Professor of Neurosurgery, Mayo Clinic College of Medicine
1999-2007: Professor of Neurosurgery, Mayo Clinic College of Medicine
2007-2012: Professor of Neurological Surgery, Ohio State University School of Medicine
2008-2012: Vice Chair of Neurological Surgery, Ohio State University School of Medicine

Selected Professional Memberships and Appointments

American Board of Pediatric Neurosurgery
American Association of Neurological Surgeons
Congress of Neurological Surgeons
American College of Surgeons
American Medical Association
American Society of Pediatric Neurosurgeons
Society for Neuro-Oncology
American Academy of Neurological Surgery
Society of Neurological Surgeons
Editorial Board Member, Journal of Neurosurgery
Editorial Board Member, Neurosurgery

Selected Recent Publications

Lal S, Carrera D, Phillips JJ, Weiss WA, Raffel C. An oncolytic measles virus-sensitive Group 3 medulloblastoma model in immune-competent mice. Neuro Oncol. 2018 Jun 14. doi: 10.1093/neuonc/noy089. [Epub ahead of print] PubMed PMID: 29912438.

Kline CN, Packer RJ, Hwang EI, Raleigh DR, Braunstein S, Raffel C, Bandopadhayay P, Solomon DA, Aboian M, Cha S, Mueller S. Case-based review: pediatric medulloblastoma. Neurooncol Pract. 2017 Sep;4(3):138-150. doi: 10.1093/nop/npx011. Epub 2017 Aug 11. Review. PubMed PMID: 29692919; PubMed Central PMCID: PMC5909805.

Sankar K, Kyono W, Raffel C, Nicolaides T. Suprasellar Germinoma Presenting with Slipped Capital Femoral Epiphysis: Case Report. Cureus. 2017 Dec 16;9(12):e1954. doi: 10.7759/cureus.1954. PubMed PMID: 29487768; PubMed Central PMCID: PMC5815654.

Lal S, Raffel C. Using Cystine Knot Proteins as a Novel Approach to Retarget Oncolytic Measles Virus. Mol Ther Oncolytics. 2017 Sep 29;7:57-66. doi: 10.1016/j.omto.2017.09.005. eCollection 2017 Dec 15. PubMed PMID: 29367943; PubMed Central PMCID: PMC5771132.

Quintanilla-Bordás C, Nourbakhsh B, Strober J, Raffel C, Waubant E. Clinical Reasoning: A 16-year-old girl with subacute weakness and sensory loss. Neurology. 2017 Jun 6;88(23):e225-e229.

Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AG, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol 2017 May 1;19(5):699-709.

Lal S, Peng KW, Steele MB, Jenks N, Ma H, Kohanbash G, Phillips JJ, Raffel C. Safety Study: Intraventricular Injection of a Modified Oncolytic Measles Virus into Measles-Immune, hCD46-Transgenic, IFNαRko Mice. Hum Gene Ther Clin Dev. 2016 Dec;27(4):145-151. PubMed PMID: 27604429.

Studebaker AW, Hutzen B, Pierson CR, Shaffer TA, Raffel C, Jackson EM. Oncolytic measles virus efficacy in murine xenograft models of atypical teratoid rhabdoid tumors. Neuro Oncol. 2015 Dec;17(12):1568-77. doi: 10.1093/neuonc/nov058. PubMed PMID: 25838138; PubMed Central PMCID: PMC4633925.

Hutzen B, Raffel C, Studebaker AW. Advances in the design and development of oncolytic measles viruses. Oncolytic Virother. 2015 Aug 27;4:109-18. doi: 10.2147/OV.S66078. Review. PubMed PMID: 27512675; PubMed Central PMCID: PMC4918395.

Ostling L, Raffel C. Complications following preresection shunting in patients with posterior fossa tumors. J Neurosurg Pediatr. 2015 Jan;15(1):1-3. doi: 10.3171/2014.9.PEDS14440. PubMed PMID: 25380172.

Muszynski JA, Nofziger R, Greathouse K, Nateri J, Hanson-Huber L, Steele L, Nicol K, Groner JI, Besner GE, Raffel C, Geyer S, El-Assal O, Hall MW. Innate immune function predicts the development of nosocomial infection in critically injured children. Shock. 2014 Oct;42(4):313-21. doi: 10.1097/SHK.0000000000000217. PubMed PMID: 24978895; PubMed Central PMCID: PMC4167175.

Hutzen B, Bid HK, Houghton PJ, Pierson CR, Powell K, Bratasz A, Raffel C, Studebaker AW. Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin. BMC Cancer. 2014 Mar 19;14:206. doi: 10.1186/1471-2407-14-206. PubMed PMID: 24646176; PubMed Central PMCID: PMC3995427.

Raffel C. Cerebellar tonsil position and Chiari malformation. J Neurosurg. 2013 Sep;119(3):810-1. doi: 10.3171/2013.3.JNS1339. PubMed PMID: 23767894.

Hutzen B, Pierson CR, Russell SJ, Galanis E, Raffel C, Studebaker AW. Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine. BMC Cancer 2012;12(1):508.

Raffel C. Editorial: glioblastoma subtype. J Neurosurg 2012;117(3):474; discussion 475.

Studebaker AW, Hutzen B, Pierson CR, Russell SJ, Galanis E, Raffel C. Oncolytic measles virus prolongs survival in a murine model of cerebral spinal fluid-disseminated medulloblastoma Neuro Oncol 2012;14(4):459-70.

Raffel C, Rutka JT. Central nervous system primitive neuroectodermal tumors: still a useful classification? Neurosurg Focus 2011;30(1):Introduction.

Hnojciková M, Nickels KC, Wetjen NM, Buchhalter JR, Raffel C, Wirrell EC. EEG and neuroimaging studies in young children having epilepsy surgery. Pediatr Neurol 2010;43(5):335-40.

Peruzzi P, Corbitt RJ, Raffel C. Magnetic resonance imaging versus ultrasonography for the in utero evaluation of central nervous system anomalies. J Neurosurg Pediatr 2010;6(4):340-5.

Gill K, Zachary B, Williams C, Raffel C, Boue D, Barson W. Recurrent meningitis in a teenager. Pediatr Infect Dis J 2010;29(10):984, 988-9.

Niazi TN, Klimo P Jr, Anderson RC, Raffel C. Diagnosis and management of arteriovenous malformations in children. Neurosurg Clin N Am 2010;21(3):443-56.

Studebaker AW, Kreofsky CR, Pierson CR, Russell SJ, Galanis E, Raffel C. Treatment of medulloblastoma with a modified measles virus. Neuro Oncol 2010;12(10):1034-42.

Johnson JN, Hartman TK, Barbaresi W, Raffel C, Colby CE. Developmental outcomes for neonatal dural arteriovenous fistulas. J Neurosurg Pediatr 2009;3(2):105-9.