S. Scott Panter PhD
Assistant Professor of Neurological Surgery
Principal Investigator, Cerebrovascular Research
Research Chemist, Veterans Affairs Medical Center
Dr. Panter's research focus is the role of iron, heme, or hemoglobin in central nervous system injury, using experimental systems including biochemistry, cell culture, and in vivo models to study this process of tissue damage. He showed in mixed cultures of neurons and astrocytes that hemoglobin causes neuronal injury, which was subsequently confirmed in the clinical trials of a hemoglobin-based blood substitute. He has developed models of subarachnoid and intracerebral hemorrhage, showing that hemoglobin causes significant infarcts and induces heat shock proteins. Currently, his laboratory is developing new models of focal and global ischemia and traumatic brain injury. These models are being used to test a new method of drug delivery into the brain — intranasal, which bypasses the blood-brain barrier.
Education, Training, and Previous Positions
- 972: BA, University of Colorado
1976: MA, University of Colorado
1981: PhD, University of Colorado
1981-1984: NIMH Postdoctoral Fellow, Dight Institute for Human Genetics, University of Minnesota
1984-1987: Postdoctoral Associate, Department of Laboratory Medicine and Pathology and The Dight Laboratories, University of Minnesota
1987-1990: Research Neurochemist, Department of Neurology, UCSF and San Francisco Veterans Administration Hospital
1990-1993: Research Chemist, Letterman Army Institute of Research, Presidio of San Francisco, CA
Selected Professional Memberships and Appointments
- Sigma Xi
Society for Neurotrauma
Society for Neuroscience
American Federation for Medical Research
Society for Free Radical Biology and Medicine
International BioIron Society
Network for the Advancement of Transfusion Alternatives
Selected Honors and Awards
- NIMH Predoctoral Fellow in Pharmacogenetics (University of Colorado)
NINCDS Postdoctoral Fellow in Behavioral Genetics (University of Minnesota)
1992: Sustained Superior Performance Award, U.S. Army
1994-1997: DOD/DVA Cooperative Research Grant
1994-present: NIH RO1, NHLBI
2002-present: DOD-ONR, G.T. Manley, MD, PhD, Co-PI
2004: John Alexander MD Research Award, American Heart Association
2004-2006: Grant-in-Aid Award, American Heart Association
Selected Recent Publications
Silvestrini MT, Yin D, Martin AJ, Coppes VG, Mann P, Larson PS, Starr PA, Zeng
X, Gupta N, Panter SS, Desai TA, Lim DA. Interventional magnetic resonance
imaging-guided cell transplantation into the brain with radially branched
deployment. Mol Ther. 2015 Jan;23(1):119-29.
Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim DA. Radially branched deployment for more efficient cell transplantation at the scale of the human brain. Stereotact Funct Neurosurg. 2013;91(2):92-103.
Bingham D, John CM, Levin J, Panter SS, Jarvis GA. Post-injury conditioning with lipopolysaccharide or lipooligosaccharide reduces inflammation in the brain. J Neuroimmunol. 2013 Mar 15;256(1-2):28-37.
Hanson LR, Fine JM, Renner DB, Svitak AL, Burns RB, Nguyen TM, Tuttle NJ, Marti DL, Panter SS, Frey WH 2nd. Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice. Drug Deliv Transl Res. 2012 Jun;2(3):160-8.
Bingham D, John CM, Panter SS, Jarvis GA. Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures. Brain Res Bull. 2011 Jul 15;85(6):403-9.
Odland RM, Panter SS, Rockswold GL. The effect of reductive ventricular osmotherapy on the osmolarity of artificial cerebrospinal fluid and the water content of cerebral tissue ex vivo. J Neurotrauma. 2011 Jan;28(1):135-42.
Hanson LR, Roeytenberg A, Martinez PM, Coppes VG, Sweet DC, Rao RJ, Marti DL, Hoekman JD, Matthews RB, Frey WH 2nd, Panter SS. Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke. J Pharmacol Exp Ther. 2009 Sep;330(3):679-86.
Rosenthal G, Morabito D, Cohen M, Roeytenberg A, Derugin N, Panter SS, Knudson MM, Manley G. Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation. J Neurosurg. 2008 Mar;108(3):575-87.
Stankiewicz J, Panter SS, Neema M, Arora A, Batt CE, Bakshi R. Iron in chronic brain disorders: imaging and neurotherapeutic implications [Review]. Neurotherapeutics. 2007;4(3):371-86.
Wei G, Wang D, Lu H, Parmentier S, Wang Q, Panter SS, Frey WH 2nd, Ying W. Intranasal administration of a PARG inhibitor profoundly decreases ischemic brain injury. Front Biosci 2007;12:4986-96.
Manley GT, Rosenthal G, Lam M, Morabito D, Yan D, Derugin N, Bollen A, Knudson MM, Panter SS. Controlled cortical impact in swine: pathophysiology and biomechanics. J Neurotrauma 2006;23(2):128-39.
Gum ET, Swanson RA, Alano C, Liu J, Hong S, Weinstein PR, Panter SS. Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death. Stroke 2004;35(2):590-5.
Mautes AE, Bergeron M, Sharp FR, Panter SS, Weinzierl M, Guenther K, Noble LJ. Sustained induction of heme oxygenase-1 in the traumatized spinal cord. Exp Neurol. 2000;166(2):254-65.
Tsuchiya D, Hong S, Suh SW, Kayama T, Panter SS, Weinstein PR. Mild hypothermia reduces zinc translocation, neuronal cell death, and mortality after transient global ischemia in mice. J Cereb Blood Flow Metab. 2002;22(10):1231-8.