S. Scott Panter PhD
Assistant Professor of Neurological Surgery
Principal Investigator, Cerebrovascular Research
Research Chemist, Veterans Affairs Medical Center
Dr. Panter's research focus is the role of iron, heme, or hemoglobin in central nervous system injury, using experimental systems including biochemistry, cell culture, and in vivo models to study this process of tissue damage. He showed in mixed cultures of neurons and astrocytes that hemoglobin causes neuronal injury, which was subsequently confirmed in the clinical trials of a hemoglobin-based blood substitute. He has developed models of subarachnoid and intracerebral hemorrhage, showing that hemoglobin causes significant infarcts and induces heat shock proteins. Currently, his laboratory is developing new models of focal and global ischemia and traumatic brain injury. These models are being used to test a new method of drug delivery into the brain — intranasal, which bypasses the blood-brain barrier.
Education, Training, and Previous Positions
- 972: BA, University of Colorado
1976: MA, University of Colorado
1981: PhD, University of Colorado
1981-1984: NIMH Postdoctoral Fellow, Dight Institute for Human Genetics, University of Minnesota
1984-1987: Postdoctoral Associate, Department of Laboratory Medicine and Pathology and The Dight Laboratories, University of Minnesota
1987-1990: Research Neurochemist, Department of Neurology, UCSF and San Francisco Veterans Administration Hospital
1990-1993: Research Chemist, Letterman Army Institute of Research, Presidio of San Francisco, CA
Selected Professional Memberships and Appointments
- Sigma Xi
Society for Neurotrauma
Society for Neuroscience
American Federation for Medical Research
Society for Free Radical Biology and Medicine
International BioIron Society
Network for the Advancement of Transfusion Alternatives
Selected Honors and Awards
- NIMH Predoctoral Fellow in Pharmacogenetics (University of Colorado)
NINCDS Postdoctoral Fellow in Behavioral Genetics (University of Minnesota)
1992: Sustained Superior Performance Award, U.S. Army
1994-1997: DOD/DVA Cooperative Research Grant
1994-present: NIH RO1, NHLBI
2002-present: DOD-ONR, G.T. Manley, MD, PhD, Co-PI
2004: John Alexander MD Research Award, American Heart Association
2004-2006: Grant-in-Aid Award, American Heart Association
Selected Recent Publications
Stankiewicz J, Panter SS, Neema M, Arora A, Batt CE, Bakshi R. Iron in chronic brain disorders: imaging and neurotherapeutic implications [Review]. Neurotherapeutics. 2007;4(3):371-86.
Wei G, Wang D, Lu H, Parmentier S, Wang Q, Panter SS, Frey WH 2nd, Ying W. Intranasal administration of a PARG inhibitor profoundly decreases ischemic brain injury. Front Biosci 2007;12:4986-96.
Manley GT, Rosenthal G, Lam M, Morabito D, Yan D, Derugin N, Bollen A, Knudson MM, Panter SS. Controlled cortical impact in swine: pathophysiology and biomechanics. J Neurotrauma 2006;23(2):128-39.
Gum ET, Swanson RA, Alano C, Liu J, Hong S, Weinstein PR, Panter SS. Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death. Stroke 2004;35(2):590-5.
Mautes AE, Bergeron M, Sharp FR, Panter SS, Weinzierl M, Guenther K, Noble LJ. Sustained induction of heme oxygenase-1 in the traumatized spinal cord. Exp Neurol. 2000;166(2):254-65.
Tsuchiya D, Hong S, Suh SW, Kayama T, Panter SS, Weinstein PR. Mild hypothermia reduces zinc translocation, neuronal cell death, and mortality after transient global ischemia in mice. J Cereb Blood Flow Metab. 2002;22(10):1231-8.