Linda Noble-Haeusslein PhD
Professor, Department of Neurological Surgery and Department of Physical Therapy and Rehabilitation
Alvera L. Kan Endowed Chair of Neurological Surgery
Co-Director, Neurobehavioral Core for Rehabilitation Research
Dr. Noble focuses on the neurobiology of traumatic injury to the central nervous system. The extent of functional recovery after traumatic brain or spinal cord injury is not simply the consequence of the initial mechanical destruction of tissue, but is also attributed to the evolution of complex secondary events that contribute to early and delayed cell injury. The Noble laboratory employs experimental models of traumatic brain and spinal cord injury in the rodent to study the early events that contribute to cell injury and impair functional recovery. Researchers are focused on the role of the blood-brain and spinal-cord barriers in early pathogenesis after traumatic injury, the acute and chronic influences of inflammation on both injury and repair mechanisms, and the identification of those cellular defense mechanisms, intrinsic to the brain and spinal cord, that protect against secondary injury and may be essential for limiting the extent of cell injury. These studies are funded by the National Institutes of Health.
Education, Training, and Previous Positions
- 1975: BS, University of Utah
1975-76: Physical Therapist, Cedars-Sinai Medical Center, Los Angeles
1977-78: Physical Therapist, University of California Medical Center, Los Angeles
1982: PhD, University of California at Los Angeles
1982-83: Instructor, Department of Anatomy, University of Maryland, Baltimore
1983-85: Research Associate, Department of Anatomy, Georgetown University
1985-90: Assistant Research Neuroanatomist, Neurology Department, UCSF
1990-93: Assistant Professor, Neurological Surgery, UCSF
1993-99: Associate Professor, Neurological Surgery, UCSF
2000-present: Professor, Neurological Surgery, UCSF
Selected Professional Memberships and Appointments
- Society for Neuroscience
American Association of Anatomists
Society for Neurotrauma
Editorial Board: Journal of Neurotrauma
Editorial Board: International Journal of Neuroprotection and Neuroregeneration
Selected Recent Publications
Hsu JY, McKeon R, Goussev S, Werb Z, Lee JU, Trivedi A, Noble-Haeusslein LJ. Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci 2006;26(39):9841-50.
Pullela R, Raber J, Pfankuch T, Ferriero DM, Claus CP, Koh SE, Yamauchi T, Rola R, Fike JR, Noble-Haeusslein LJ. Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments. Dev Neurosci 2006;28(4-5):396-409.
Lin Y, Vreman HJ, Wong RJ, Tjoa T, Yamauchi T, Noble-Haeusslein LJ. Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord. J Cereb Blood Flow Metab 2007;27(5):1010-21.
Hsu JY, Bourguignon LY, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci 2008;28(50):13467-77.
Tsuru-Aoyagi K, Potts MB, Trivedi A, Pfankuch T, Raber J, Wendland M, Claus CP, Koh SE, Ferriero D, Noble-Haeusslein LJ. Glutathione peroxidase activity modulates recovery in the injured immature brain. Ann Neurol 2009;65(5):540-9.
Yoneyama-Sarnecky T, Olivas AD, Azari S, Ferriero DM, Manvelyan HM, Noble-Haeusslein LJ. Heme oxygenase-2 modulates early pathogenesis after traumatic injury to the immature brain. Dev Neurosci 2010;32(1):81-90.