Michael W. McDermott MD

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Professor in Residence of Neurological Surgery, Halperin Endowed Chair

Neurosurgical Director, UCSF Gamma Knife® Radiosurgery Program

Vice Chairman, Department of Neurological Surgery, UCSF


Dr. McDermott's clinical specialty interests include stereotactic neurosurgery and Gamma Knife® radiosurgery, in particular for tumors of the central nervous system, meningiomas, and skull base surgery. Co-director of the UCSF Gamma Knife® Radiosurgery Program, he also practices in the Department's Adult Brain Tumor Program, Clinical Neuro-Oncology Program, Central Nervous System Infections and AIDS Program, and Hydrocephalus and Shunt Program for Adults.

Dr. McDermott's research includes studies related to malignant meningiomas and novel agents for treatment, toxicity to normal tissue after radiosurgery in a rat model, and the ability of a biologic compound to enhance the delivery of oxygen to tumors and thereby increase the effectiveness of therapy. Dr. McDermott's clinical research is focused on correlations of intraoperative tumor pathology with spectroscopy of genetic markers in primary brain tumors and comparative genomic hybridization techniques, and he is a participating research clinician in the human gene therapy clinical trials at UCSF.

Education, Training, and Previous Positions

1978: BS, University of Toronto
1982: MD, University of Toronto Medical School
1982-1983: Mixed Internship, St. Michael's Hospital, Toronto, Ontario
1983-1988: Neurosurgery Residency, University of British Columbia
1988-1989: Clinical Instructor, Neuro-Oncology Service, Brain Tumor Research Center, UCSF
1989-1990: Research Fellow, UCSF
1990-1992: Assistant Clinical Professor, Division of Neurosurgery, Department of Surgery, University of British Columbia
1992-1998: Assistant Professor, Department of Neurological Surgery, UCSF
1998-2004: Associate Professor, Department of Neurological Surgery, UCSF
2004-present: Professor, Department of Neurological Surgery, UCSF

Selected Professional Memberships and Appointments

Canadian Medical Association
Fellow, Royal College of Physicians and Surgeons of Canada
Canadian Neurosurgical Society
American Association of Neurological Surgeons: Joint Section on Tumors and Joint Section on Stereotactic and Functional Neurosurgery
Foundation for International Education in Neurological Surgery
California Neurosurgical Society
North American Skull Base Society
American Society of Stereotactic and Functional Neurosurgery
International Society for Functional & Stereotactic Neurosurgery
Society for Neuro-oncology
Congress of Neurological Surgeons

Selected Honors and Awards

1982: Frank K. Horner Silver Medal Award, Graduate with Honors, University of Toronto Medical School
1988: Graduating Residents Award, Department of Surgery, University of British Columbia
1991: Master Teacher in Surgery Award, Department of Surgery, University of British Columbia
1995: Harold Rosegay Resident Teaching Award, Department of Neurological Surgery, University of California, San Francisco

Selected Recent Publications

Striedinger K, VandenBerg SR, Baia GS, McDermott MW, Gutmann DH, Lal A. The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP. Neoplasia 2008;10(11):1204-12.
 
Sughrue ME, McDermott MW, Parsa AT. Vision salvage after resection of a giant meningioma in a patient with a loss in light perception [published online ahead of print October 24, 2008]. J Neurosurg. doi: 10.3171/2008.7.JNS08260
 
Baia GS, Stifani S, Kimura ET, McDermott MW, Pieper RO, Lal A. Notch activation is associated with tetraploidy and enhanced chromosomal instability in meningiomas. Neoplasia 2008;10(6):604-12.
 
Sanai N, Wachhorst SP, Gupta NM, McDermott MW. Transcerebellar stereotactic biopsy for lesions of the brainstem and peduncles under local anesthesia. Neurosurgery 2008;63(3):460-8.
 
Huang K, Sneed PK, Kunwar S, Kragten A, Larson DA, Berger MS, Chan A, Pouliot J, McDermott MW. Surgical resection and permanent iodine-125 brachytherapy for brain metastases [published online ahead of print August 22, 2008]. J Neurooncol. doi: 10.1007/s11060-008-9686-2
 
Carvalho LH, Smirnov I, Baia GS, Modrusan Z, Smith JS, Jun P, Costello JF, McDermott MW, Vandenberg SR, Lal A. Molecular signatures define two main classes of meningiomas. Mol Cancer 2007;6:64.
 
Baia GS, Dinca EB, Ozawa T, Kimura ET, McDermott MW, James CD, Vandenberg SR, Lal A. An Orthotopic Skull Base Model of Malignant Meningioma. Brain Pathol 2007;18(2):172-9.
 
Achrol AS, Kim H, Pawlikowska L, Trudy Poon KY, McCulloch CE, Ko NU, Johnston SC, McDermott MW, Zaroff JG, Lawton MT, Kwok PY, Young WL. Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment. Neurosurgery 2007;61(4):731-40.
 
Carvalho LH, Smirnov I, Baia GS, Modrusan Z, Smith JS, Jun P, Costello JF, McDermott MW, Vandenberg SR, Lal A. Molecular signatures define two main classes of meningiomas. Mol Cancer 2007;6:64.
 
Martin AJ, Cha S, Higashida RT, Cullen SP, Halbach V, Dowd CF, McDermott MW, Saloner DA. Assessment of vasculature of meningiomas and the effects of embolization with intra-arterial MR perfusion imaging: a feasibility study. AJNR Am J Neuroradiol 2007;28(9):1771-7.
 
Kased N, Huang K, Nakamura JL, Sahgal A, Larson DA, McDermott MW, Sneed PK. Gamma Knife radiosurgery for brainstem metastases: the UCSF experience. J Neurooncol 2008;86(2):195-205.
 
Dagnew E, Kanski J, McDermott MW, Sneed PK, McPherson C, Breneman JC, Warnick RE. Management of newly diagnosed single brain metastasis using resection and permanent iodine-125 seeds without initial whole-brain radiotherapy: a two institution experience. Neurosurg Focus 2007;22(3):E3.
 
Smith JS, Lal A, Harmon-Smith M, Bollen AW, McDermott MW. Association between absence of epidermal growth factor receptor immunoreactivity and poor prognosis in patients with atypical meningioma. J Neurosurg 2007;106(6):1034-40.
 
Wang VY, Barbaro NM, Lawton MT, Pitts L, Kunwar S, Parsa AT, Gupta N, McDermott MW. Complications of lumboperitoneal shunts. Neurosurgery 2007;60(6):1045-1049.
 
Chen AM, Chang S, Pouliot J, Sneed PK, Prados MD, Lamborn KR, Malec MK, McDermott MW, Berger MS, Larson DA. Phase I trial of gross total resection, permanent iodine-125 brachytherapy, and hyperfractionated radiotherapy for newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys 2007;69(3):825-30.
 
Smith JS, Parney IF, Lamborn KR, McDermott MW, Sneed PK, Chang SM. Treatment for posterior fossa dissemination of primary supratentorial glioma. J Neurosurg 2007;106(4):567-74.
 
Yoo H, Baia GS, Smith JS, McDermott MW, Bollen AW, Vandenberg SR, Lamborn KR, Lal A. Expression of the hypoxia marker carbonic anhydrase 9 is associated with anaplastic phenotypes in meningiomas. Clin Cancer Res 2007;13(1):68-75.
 
Chi JH, Parsa AT, Berger MS, Kunwar S, McDermott MW. Extended bifrontal craniotomy for midline anterior fossa meningiomas: minimization of retraction-related edema and surgical outcomes. Neurosurgery 2006;59(4 Suppl 2):ONS426-33.
 
Smith JS, Quiñones-Hinojosa A, Phillips JJ, Bollen AW, McDermott MW, Cha S. Limitations of diffusion-weighted imaging in distinguishing between a brain tumor and a central nervous system histoplasmoma. J Neurooncol 2006;79(2):217-8.
 
Baia GS, Slocum AL, Hyer JD, Misra A, Sehati N, VandenBerg SR, Feuerstein BG, Deen DF, McDermott MW, Lal A. A genetic strategy to overcome the senescence of primary meningioma cell cultures. J Neurooncol 2006;78(2):113-21.
 
Jun P, Garcia J, Tihan T, McDermott MW, Cha S. Perfusion MR imaging of an intracranial collision tumor confirmed by image-guided biopsy. AJNR Am J Neuroradiol 2006;27(1):94-7.
 
Goldsmith B, McDermott MW. Meningioma [Review]. Neurosurg Clin N Am 2006;17(2):111-20, vi.
 
Barker FG 2nd, McDermott MW. Prizes, lectures, and awards of the American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on Tumors. Neurosurg Focus [serial on the Internet]. 2005 [cited 2005 Aug 25];18(4):[8p.]. Available from: http://www.aans.org/education/journal/neurosurgical/apr05/18-4-11.pdf.
 
Cuevas IC, Slocum AL, Jun P, Costello JF, Bollen AW, Riggins GJ, McDermott MW, Lal A. Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cancer Res 2005;65(12):5070-5.