Jennifer Clarke MD
Assistant Clinical Professor of Neurology and Neurological Surgery
Principal Investigator, Brain Tumor Research Center
Dr. Clarke specializes in novel approaches to the treatment of brain tumors in adult patients. As a member of the Brain Tumor Research Center, she is a co-investigator on single-institution clinical trials designed and run at UCSF, as well as multi-institution trials through the National Cancer Institute’s North American Brain Tumor Consortium. In addition to the design of clinical trials, her research interests include novel imaging methods of characterizing tumors and their response to treatment. In particular, she is interested in the delineation of treatment effect from recurrent tumor and in the imaging of tumors in patients receiving anti-angiogenic agents. Other research interests include the evaluation of molecular methods of characterizing tumors and the assessment/improvement of quality of life in brain tumor patients. She also teaches and precepts neurology residents, introducing them to the subspecialty field of neuro-oncology.
Education, Training, and Previous Positions
- 1995: BS, California Institute of Technology (Caltech)
2001: MPH, University of California, Berkeley School of Public Health
2002: MD, University of California, San Francisco
2002-2003: Internship, Medicine, St. Mary's Medical Center, San Francisco
2003-2006: Resident, Department of Neurology, University of California, San Francisco
2006-2008: Fellow, Neuro-Oncology, Memorial Sloan-Kettering Cancer Center
Selected Professional Memberships and Appointments
- American Academy of Neurology
Society for Neuro-Oncology
American Society of Clinical Oncology
Selected Honors and Awards
- 1991-1992: Millikan Scholar, Caltech
1993-1994: McLean Scholarship, Caltech
1994: Doris S. Perpall Speaking Award, Caltech
2000: University Fellowship, UC Berkeley
2001: UCSF Class of 1966 Scholarship
2003: Intern of the Year, St. Mary's Medical Center
2008: ASCO Foundation Merit Award
Selected Recent Publications
Clarke J, Abrey L, Karimi S, Lassman A. Psuedoprogression (PsPr) after concurrent radiotherapy (RT) and temozolomide (TMZ) for newly diagnosed glioblastoma multiforme (GBM). J Clin Oncol 2008;26(20 suppl; abstr 2025).
De Angelis L, Clarke J, Perez H. Retrospective analysis of patients with leptomeningeal disease (LMD) in the MRI era. J Clin Oncol 2008;26(20 suppl; abstr 2070).
Clarke J, Sul J, DeAngelis L, Lassman A, Hormigo A, Nolan C, Gavrilovic I, Gu B, Panageas K, Abrey L. A randomized phase II trial of concurrent temozolomide (TMZ) and radiotherapy (RT) followed by dose-dense compared to metronomic TMZ and maintenance cis-retinoic acid for patients with newly diagnosed glioblastoma multiforme (GBM). Presented on November 15-18, 2007 at the 12th Annual Meeting of the Society for Neuro-Oncology, Dallas, TX.
Clarke J, Johnston SC, Bernstein R, Tong D, Hemphill III JC. External validation of the ICH score. Neurocrit Care 2004;1(1):53-60.