Edward F. Chang MD

Edward F. Chang MD

Associate Professor in Residence of Neurological Surgery and Physiology 

Co-Director, Center for Neural Engineering at UC Berkeley and San Francisco

Faculty, Keck Center for Integrative Neuroscience

Faculty, Biological Sciences Graduate Program


Edward Chang MD is Associate Professor of Neurological Surgery and Physiology at UCSF. Dr. Chang’s clinical expertise is surgical therapies for intractable epilepsy, trigeminal neuralgiapain, and adult brain tumors. He specializes in advanced neurophysiologic brain mapping methods, including awake speech and motor mapping, to safely perform neurosurgical procedures in eloquent areas of the brain. He is the recipient of the NIH Director’s New Innovator Award, Klingenstein Fellowship, and Grass Foundation Young Investigator Award from the American Epilepsy Society.

His groundbreaking work has been featured by the US News and World Report ("Secrets of Your Brain" 2011 special issue), San Francisco Magazine, San Francisco Chronicle, New York Times and Wall Street Journal.

Read About Dr. Chang's Current Research ►

Education, Training, and Previous Positions

1997: BA, Amherst College
2004: MD, University of California, San Francisco
2004-2010: Residency, Neurological Surgery, University of California, San Francisco
2008-2009: Fellowship, Cognitive Neurophysiology Helen Wills Neuroscience Institute, University of California, Berkeley

Selected Professional Memberships and Appointments

Congress of Neurological Surgeons
American Association of Neurological Surgeons (Harvey Cushing Society)
Society for Neuroscience

Selected Honors and Awards

1997: Magna cum laude, Amherst College
1997: Sigma Xi Award
1998: John Woodruff Simpson Medical Studies Fellowship Award, Amherst College
2001: HHMI Medical Student Research Fellowship
2003: HHMI Continued Support for Completion of Medical Studies Award
2002: Michael Goldberger Award, National and International Neurotrauma Societies
2002: Otological Research Fellowship Award, Deafness Research Foundation
2003: American Heart Association Medical Student Research Award
2003: Alpha Omega Alpha
2004: UCSF Dean's Prize for Research
2004: UCSF Distinguished Teaching Award (Neuroanatomy)
2006: Kaiser Resident Research Award, San Francisco Neurological Society
2006: Clinical Research Award, Western Neurosurgical Society
2008: Wilder Penfield Fellowship, Congress of Neurological Surgeons
2008: Ruth L. Kirschstein National Research Service Award (NRSA) Research Training Grant (NIH-NINDS)
2008: Howard Nafzigger Award, UCSF Neurological Surgery
2008: Clinical Research Award, Western Neurosurgical Society
2009: Ronald Bittner Award, American Association of Neurological Surgeons
2010: Henry Newman Award, San Francisco Neurological Society
2009-13: Pathway to Independence Award (K99/R00 NIH NINDS)
2011: Klingenstein Fellowship Award in the Neurosciences,
2011: Young Investigator Award, Grass Foundation-American Epilepsy Society
2011-16: NIH New Director's Innovation Award (DP2)

Selected Recent Publications

Clinical Articles

Chang EF, Wang DD, Perry DW, Barbaro NM, Berger MS. Homotopic organization of right hemisphere essential language sites in right and bilateral cerebral hemispheric dominance. J Neurosurg 2011;114(4):893-902.

Chang EF, Wang DD, Barkovich AJ, Tihan T, Auguste KI, Sullivan JE, Garcia PA, Barbaro NM. Seizure freedom after surgery for malformations of cortical development. Ann Neurol 2011;70(1):151-62.

Englot DJ, Barbaro NM, Berger MS, Chang EF. Predictors of seizure freedom after surgical resection of supratentorial low-grade gliomas. J Neurosurg 2011;115(2):240-4.

Englot DJ, Han SJ, Lawton MT, Chang EF. Predictors of seizure-freedom in the surgical treatment of supratentorial cavernous malformations. Clinical article. J Neurosurg 2011;115(6):1169-74.

Englot DJ, Berger MS, Barbaro NM, Chang EF. Extent of surgical resection predicts seizure freedom in low-grade temporal lobe brain tumors. Neurosurgery 2012;70(4):921-8.

Englot DJ, Berger MS, Barbaro NM, Chang EF. Factors associated with seizure freedom in the surgical resection of glioneuronal tumors. Epilepsia 2012;53(1):51-7.

Englot DJ, Ouyang D, Barbaro NM, Garcia PA, Chang EF. Epilepsy surgery trends in United States, 1990-2008. Neurology 2012;17;78(16):1200-6.

Rolston JD, Englot DJ, Wang DD, Shih T, Chang EF. Comparison of seizure control outcomes and safety of vagus nerve, deep brain, and responsive neurostimulation: evidence from randomized controlled trials. Neurosurg Focus 2012;32(3)E14.

Englot DJ, Ouyang D, Wang DD, Rolston JD, Garcia PA, Chang EF. Relationship between hospital surgical volume, lobectomy rates, and adverse perioperative events at U.S. Epilepsy Centers. J Neurosurg 2013;118(1):169-74.

Wang DD, Deans A, Barkovich AJ, Tihan T, Garcia PA, Barbaro NM, Chang EF. Transmantle sign in cortical dysplasia: a unique radiologic entity with excellent prognosis for seizure-control. J Neurosurg 2013;118(2):337-44.

Chang EF, Clark A, Smith JS, Polley MY, Chang SM, Barbaro NM, McDermott MW, Berger MS. Functional mapping-guided resection of low-grade gliomas in eloquent areas of the brain: improvement of long-term survival. J Neurosurg 2011; 114(3):566-73.

Chang EF, Quigg M, Oh MC, Dillon WP, Ward MM, Laxer KD, Broshek DK, Barbaro NM. Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy. Neurology 2010; 74(2):165-72.

Research Articles

Bouchard KE, Mesgarani N, Johnson K, Chang EF. Functional organization of human sensorimotor cortex for speech articulation. Nature 2013;495(7441):327-32.

Chang EF*, Niziolek C*, Nagarajan SS, Knight RT, Houde JS. Human cortical sensorimotor network underlying feedback control of vocal pitch. PNAS 2013;110(7):2653-8.

Mesgarani N, Chang EF. Selective cortical representation of attended speaker in multi-talker speech perception. Nature 2012; 485(7397):233-6.

Pasley B, David SV, Mesgarani N, Flinker A, Shamma SA, Crone NE, Knight RT, Chang EF. Reconstructing speech from human auditory cortex. PLoS Biology 2012;10(1):e1001251.

Cheung C, Chang EF. Real-time, single-trial mapping of cortical event-related activation. J Neural Eng 2012;9(4):046018.

Chang EF*, Edwards E*, Nagarajan SS, Fogelson N, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT. Cortical spatiotemporal dynamics underlying phonological target detection in humans. J Cog Neurosci 2011;23(6):1437-46.

Chang EF*, Rieger J*, Johnson KD, Berger MS, Barbaro NM, Knight RT. Categorical speech representation in the human superior temporal gyrus. Nat Neurosci 2010;13(11):1428-32.