Edward F. Chang MD
Assistant Professor in Residence of Neurological Surgery and Physiology
Co-Director, Center for Neural Engineering at UC Berkeley and San Francisco
Faculty, Keck Center for Integrative Neuroscience
Faculty, Biological Sciences Graduate Program
Edward Chang MD is Assistant Professor of Neurological Surgery and Physiology at UCSF. Dr. Chang conducted both his medical school and neurosurgery residency training at the top-ranked UCSF School of Medicine. He is recipient of numerous national awards and prestigious NIH grant funding for his contributions to neurosurgery and neuroscience.
Dr. Chang’s clinical expertise is surgical therapies for intractable epilepsy, movement disorders, pain, and adult brain tumors. He specializes in advanced brain mapping methods, including awake speech and motor mapping, to safely perform neurosurgical procedures in eloquent areas of the brain. He also has received extensive training in deep brain stimulation for movement disorders and other implantable devices for neuromodulation, as well as neurosurgery for intractable facial pain.
His work has been featured by the US News and World Report ("Secrets of Your Brain" 2011 special issue) and World Journal (Chinese language, June 2011).
Education, Training, and Previous Positions
- 1997: BA, Amherst College
2004: MD, University of California, San Francisco
2004-2010: Residency, Neurological Surgery, University of California, San Francisco
2008-2009: Fellowship, Cognitive Neurophysiology Helen Wills Neuroscience Institute, University of California, Berkeley
Selected Professional Memberships and Appointments
- Congress of Neurological Surgeons
American Association of Neurological Surgeons (Harvey Cushing Society)
Society for Neuroscience
Selected Honors and Awards
- 1997: Magna cum laude, Amherst College
1997: Sigma Xi Award
1998: John Woodruff Simpson Medical Studies Fellowship Award, Amherst College
2001: HHMI Medical Student Research Fellowship
2003: HHMI Continued Support for Completion of Medical Studies Award
2002: Michael Goldberger Award, National and International Neurotrauma Societies
2002: Otological Research Fellowship Award, Deafness Research Foundation
2003: American Heart Association Medical Student Research Award
2003: Alpha Omega Alpha
2004: UCSF Dean's Prize for Research
2004: UCSF Distinguished Teaching Award (Neuroanatomy)
2006: Kaiser Resident Research Award, San Francisco Neurological Society
2006: Clinical Research Award, Western Neurosurgical Society
2008: Wilder Penfield Fellowship, Congress of Neurological Surgeons
2008: Ruth L. Kirschstein National Research Service Award (NRSA) Research Training Grant (NIH-NINDS)
2008: Howard Nafzigger Award, UCSF Neurological Surgery
2008: Clinical Research Award, Western Neurosurgical Society
2009: Ronald Bittner Award, American Association of Neurological Surgeons
2010: Henry Newman Award, San Francisco Neurological Society
2009-13: Pathway to Independence Award (K99/R00 NIH NINDS)
2011: Klingenstein Fellowship Award in the Neurosciences,
2011: Young Investigator Award, Grass Foundation-American Epilepsy Society
2011-16: NIH New Director's Innovation Award (DP2)
Selected Recent Publications
Mesgarani N, Chang EF. Selective cortical representation of attended speaker in multi-talker speech perception [published online ahead of print]. Nature. 2012 Apr 18. doi: 10.1038/nature11020.
Englot DJ, Ouyang D, Garcia PA, Barbaro NM, Chang EF. Epilepsy surgery trends in the United States, 1990–2008. Neurology 2012;78:1200-06.
Englot DJ, Berger MS, Chang EF, Garcia PA. Characteristics and treatment of seizures in patients with high-grade glioma: a review. Neurosurg Clin N Am 2012;23(2):227-35, vii-viii.
Rolston JD, Englot DJ, Wang DD, Shih T, Chang EF. Comparison of seizure control outcomes and the safety of vagus nerve, thalamic deep brain, and responsive neurostimulation: evidence from randomized controlled trials. Neurosurg Focus 2012;32(3):E14.
Southwell DG, Garcia PA, Berger MS, Barbaro NM, Chang EF. Long-Term Seizure Control Outcomes After Resection of Gangliogliomas [published online ahead of print]. Neurosurgery. 2012 Feb 17. doi: 10.1227/NEU.0b013e3182500a4c
Rowland NC, Englot DJ, Cage TA, Sughrue ME, Barbaro NM, Chang EF. A meta-analysis of predictors of seizure freedom in the surgical management of focal cortical dysplasia [published online ahead of print]. J Neurosurg. 2012 Feb 10. doi: 10.3171/2012.1.JNS111105.
Englot DJ, Wang DD, Rolston JD, Shih TT, Chang EF. Rates and predictors of long-term seizure freedom after frontal lobe epilepsy surgery: a systematic review and meta-analysis [published online ahead of print]. J Neurosurg. 2012 Feb 3. doi: 10.3171/2012.1.JNS111620.
Pasley BN, David SV, Mesgarani N, Flinker A, Shamma SA, Crone NE, Knight RT, Chang EF. Reconstructing speech from human auditory cortex. PLoS Biol 2012;10(1):e1001251.
Englot DJ, Han SJ, Berger MS, Barbaro NM, Chang EF. Extent of surgical resection predicts seizure freedom in low-grade temporal lobe brain tumors. Neurosurgery 2012;70(4):921-8.
Change EF, Wang DD, Barkovich AJ, Tihan T, Auguste KI, Sullivan JE, Garcia PA, Barbaro NM. Seizure freedom after surgery for malformations of cortical development. Ann Neurol 2011;70(1):151-62.
Chang EF, Wang DD, Perry DW, Barbaro NM, Berger MS. Homotopic organization of right hemisphere essential language sites in right and bilateral cerebral hemispheric dominance. J Neurosurg 2011;114(4):893-902.
Chang EF, Gabriel RA, Potts MB, Berger MS, Lawton MT. Supratentorial cavernous malformations in eloquent and deep locations: surgical approaches and outcomes. J Neurosurg 2011;114(3):814-27.
Chang EF, Clark A, Smith JS, Polley MY, Chang SM, Barbaro NM, Parsa AT, McDermott MW, Berger MS. Functional mapping-guided resection of low-grade gliomas in eloquent areas of the brain: improvement of long-term survival. J Neurosurg 2011;114(3):566-73.
Chang EF, Rieger JW, Johnson K, Berger MS, Barbaro NM, Knight RT. Categorical speech representation in human superior temporal gyrus. Nat Neurosci 2010;13(11):1428-32
Chang EF, Schrock LE, Starr PA, Ostrem JL. Long-term benefit sustained after bilateral pallidal deep brain stimulation in patients with refractory tardive dystonia. Stereotact Funct Neurosurg 2010;88(5):304-10.
Chang EF, Edwards E, Nagarajan SS, Fogelson N, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT. Cortical spatio-temporal dynamics underlying phonological target detection in humans. J Cogn Neurosci 2011;23(6):1437-46.
Chang EF, Sughrue ME, Zada G, Wilson CB, Blevins LS Jr, Kunwar S. Long term outcome following repeat transsphenoidal surgery for recurrent endocrine-inactive pituitary adenomas. Pituitary 2010;13(3):223-9.
Chang EF, Christie C, Sullivan JE, Garcia PA, Tihan T, Gupta N, Berger MS, Barbaro NM. Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients. J Neurosurg Pediatr 2010;5(1):123-30.
Ganguly K, Secundo L, Ranade G, Orsborn A, Chang EF, Dimitrov DF, Wallis JD, Barbaro NM, Knight RT, Carmena JM. Cortical representation of ipsilateral arm movements in monkey and man. J Neurosci 2009;29(41):12948-56.
Chang EF, Barbaro NM. Nonresective epilepsy surgery. Epilepsia. 2010 Feb;51 Suppl 1:87-9.
Chang EF, Quigg M, Oh MC, Dillon WP, Ward MM, Laxer KD, Broshek DK, Barbaro NM; Epilepsy Radiosurgery Study Group. Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy. Neurology 2010;74(2):165-72.
Chang EF, Gabriel RA, Potts MB, Garcia PA, Barbaro NM, Lawton MT. Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformations. Neurosurgery 2009;65(1):31-7; discussion 37-8.
Chang EF, Clark A, Jensen RL, Bernstein M, Guha A, Carrabba G, Mukhopadhyay D, Kim W, Liau LM, Chang SM, Smith JS, Berger MS, McDermott MW. Multiinstitutional validation of the University of California at San Francisco Low-Grade Glioma Prognostic Scoring System. Clinical article. J Neurosurg 2009;111(2):203-10.
Chang EF, Nagarajan SS, Mantle M, Barbaro NM, Kirsch HE. Magnetic source imaging for the surgical evaluation of electroencephalography-confirmed secondary bilateral synchrony in intractable epilepsy. J Neurosurg 2009;111(6):1248-56.
Lim DA, Tarapore P, Chang E, Burt M, Chakalian L, Barbaro N, Chang S, Lamborn KR, McDermott MW. Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. J Neurooncol. 2009;93(3):349-54.
Chang, EF, Smith, JS, Chang, SM, Lamborn, KR, Prados, MD, Butowksi, N, Barbaro, NM, Parsa, AT, Berger, MS, McDermott, MM. Pre-operative prognostic classification for hemispheric low grade gliomas in adults. J Neurosurg 2008;109(5):817-24.
Smith JS, Chang EF, Lamborn KR, Chang SM, Prados MD, Cha S, Tihan T, Vandenberg S, McDermott MW, Berger MS. Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. J Clin Oncol 2008;26(8):1338-45.
Chang EF, Potts MB, Keles GE, Lamborn KR, Chang SM, Barbaro NM, Berger MS. Seizure characteristics and control following resection in 332 patients with low-grade gliomas. J Neurosurg 2008;108(2):227-35.
Chang EF, Zada G, Kim S, Lamborn KR, Quinones-Hinojosa A, Tyrrell JB, Wilson CB, Kunwar S. Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas. J Neurosurg 2008;108(4):736-45.
Sughrue ME, Chang EF, Tyrell JB, Kunwar S, Wilson CB, Blevins LS Jr. Preoperative dopamine agonist therapy improves post-operative tumor control following prolactinoma resection. Pituitary 2009;12(3):158-64.
Chang EF, Turner RS, Ostrem JL, Davis VR, Starr PA. Neuronal Responses to Passive Movement in the Globus Pallidus Internus in Primary Dystonia. J Neurophysiol 2007;98(6):3696-707.
Chang EF, Meeker M, Holland MC. Acute traumatic intraparenchymal hemorrhage: risk factors for progression in the early post-injury period. Neurosurgery 2007 Jul;61(1 Suppl):222-31.
Smith JS, Chang EF, Rosenthal G, Meeker M, von Koch C, Manley GT, Holland MC. The role of early follow-up computed tomography imaging in the management of traumatic brain injury patients with intracranial hemorrhage. J Trauma 2007;63(1):75-82.
de Villers-Sidani E, Chang EF, Bao S, Merzenich MM. Critical period window for spectral tuning defined in the primary auditory cortex (A1) in the rat. J Neurosci 2007;27(1):180-9.
Keles GE, Chang EF, Lamborn KR, Tihan T, Chang CJ, Chang SM, Berger MS. Volumetric extent of resection and residual contrast enhancement on initial surgery as predictors of outcome in adult patients with hemispheric anaplastic astrocytoma. J Neurosurg 2006;105(1):34-40.
Chang EF, Meeker M, Holland MC. Acute traumatic intraparenchymal hemorrhage: risk factors for progression in the early post-injury period. Neurosurgery 2006;58(4):647-56; discussion 647-56.
Quinones-Hinojosa A, Chang EF, Lawton MT. The extended retrosigmoid approach: an alternative to radical cranial base approaches for posterior fossa lesions. Neurosurgery 2006;58(4 Suppl 2):ONS208-14.
Chang EF, Meeker M, Holland MC. Acute traumatic intraparenchymal hemorrhage: risk factors for progression in the early post-injury period. Neurosurgery 2006;58(4):647-56; discussion 647-56.
Wang VY, Chang EF, Barbaro NM. Focal cortical dysplasia: a review of pathological features, genetics, and surgical outcome. Neurosurg Focus [serial on the Internet]. 2006 [cited 2006 Mar 1];20(1):[7 p.]. Available from: http://www.aans.org/education/journal/neurosurgical/jan06/20-1-7.pdf.
Strata F, Delpolyi AR, Bonham BH, Chang EF, Liu RC, Nakahara H, Merzenich MM. Perinatal anoxia degrades auditory system function in rats. Proc Natl Acad Sci U S A 2005;102(52):19156-61.
Chang EF, Bao S, Imaizumi K, Schreiner CE, Merzenich MM. Development of spectral and temporal response selectivity in the auditory cortex. Proc Natl Acad Sci U S A 2005;102(45):16460-5.
Chang EF, Claus CP, Vreman HJ, Wong RJ, Noble-Haeusslein LJ. Heme regulation in traumatic brain injury: relevance to the adult and developing brain. J Cereb Blood Flow Metab 2005; [Epub ahead of print].
Lawton MT, Quinones-Hinojosa A, Chang EF, Yu T. Thrombotic intracranial aneurysms: classification scheme and management strategies in 68 patients [Review]. Neurosurgery 2005;56(3):441-54; discussion 441-54.
Bao S, Chang EF, Woods J, Merzenich MM. Temporal plasticity in the primary auditory cortex induced by operant perceptual learning. Nat Neurosci 2004;7(9):974-81.
Quinones-Hinojosa A, Chang EF, Khan SA, Lawton MT, McDermott MW. Renal cell carcinoma metastatic to the choroid mimicking intraventricular meningioma. Can J Neurol Sci 2004;31(1):115-20.
Bao S, Chang EF, Davis JD, Gobeske KT, Merzenich MM. Progressive degradation and subsequent refinement of acoustic representations in the adult auditory cortex. J Neurosci 2003;23(34):10765-75.
Chang EF, Merzenich MM. Environmental noise retards auditory cortical development. Science 2003;300(5618):498-502.
Chang EF, Wong RJ, Vreman HJ, Igarashi T, Galo E, Sharp FR, Stevenson DK, Noble-Haeusslein LJ. Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J Neurosci 2003;23(9):3689-96.
Quinones-Hinojosa A, Chang EF, Khan SA, McDermott MW. Isolated trigeminal nerve sarcoid granuloma mimicking trigeminal schwannoma: case report [Review]. Neurosurgery 2003;52(3):700-4 discussion 704-5.
Quinones-Hinojosa A, Chang EF, McDermott MW. Falcotentorial meningiomas: clinical, neuroimaging, and surgical features in six patients. Neurosurg Focus [serial on the Internet] 2003 [cited 2004 July 1];14(6):[7 p]. Available from: http://www.aans.org/education/journal/neurosurgical/jun03/14-6-11.pdf
Sato M, Chang E, Igarashi T, Noble LJ. Neuronal injury and loss after traumatic brain injury: time course and regional variability. Brain Res 2001;917(1):45-54.