Edward F. Chang MD
Associate Professor in Residence of Neurological Surgery and Physiology
Faculty, Keck Center for Integrative Neuroscience
Faculty, Biological Sciences Graduate Program
Edward Chang MD is Associate Professor of Neurological Surgery and Physiology at UCSF. Dr. Chang’s clinical expertise is surgical therapies for intractable epilepsy, trigeminal neuralgia, pain, hemifacial spasm, and adult brain tumors. He specializes in advanced neurophysiologic brain mapping methods, including awake speech and motor mapping, to safely perform neurosurgical procedures in eloquent areas of the brain. He also specializes in laser thermal ablation to treat epilepsy. Dr. Chang is a New York Stem Cell Foundation - Robertson Investigator. Dr. Chang is the recipient of the NIH Director’s New Innovator Award, Klingenstein Fellowship, and Grass Foundation Young Investigator Award from the American Epilepsy Society.
His groundbreaking work has been featured by the US News and World Report ("Secrets of Your Brain" 2011 special issue), San Francisco Magazine, San Francisco Chronicle, New York Times and Wall Street Journal.
Education, Training, and Previous Positions
- 1997: BA, Amherst College
2004: MD, University of California, San Francisco
2004-2010: Residency, Neurological Surgery, University of California, San Francisco
2008-2009: Fellowship, Cognitive Neurophysiology Helen Wills Neuroscience Institute, University of California, Berkeley
Selected Professional Memberships and Appointments
- Congress of Neurological Surgeons
American Association of Neurological Surgeons (Harvey Cushing Society)
Society for Neuroscience
Selected Honors and Awards
- 1997: Magna cum laude, Amherst College
1997: Sigma Xi Award
1998: John Woodruff Simpson Medical Studies Fellowship Award, Amherst College
2001: HHMI Medical Student Research Fellowship
2003: HHMI Continued Support for Completion of Medical Studies Award
2002: Michael Goldberger Award, National and International Neurotrauma Societies
2002: Otological Research Fellowship Award, Deafness Research Foundation
2003: American Heart Association Medical Student Research Award
2003: Alpha Omega Alpha
2004: UCSF Dean's Prize for Research
2004: UCSF Distinguished Teaching Award (Neuroanatomy)
2006: Kaiser Resident Research Award, San Francisco Neurological Society
2006: Clinical Research Award, Western Neurosurgical Society
2008: Wilder Penfield Fellowship, Congress of Neurological Surgeons
2008: Ruth L. Kirschstein National Research Service Award (NRSA) Research Training Grant (NIH-NINDS)
2008: Howard Nafzigger Award, UCSF Neurological Surgery
2008: Clinical Research Award, Western Neurosurgical Society
2009: Ronald Bittner Award, American Association of Neurological Surgeons
2010: Henry Newman Award, San Francisco Neurological Society
2009-13: Pathway to Independence Award (K99/R00 NIH NINDS)
2011: Klingenstein Fellowship Award in the Neurosciences,
2011: Young Investigator Award, Grass Foundation-American Epilepsy Society
2011-16: NIH New Director's Innovation Award (DP2)
2015-20: New York Stem Cell Foundation - Robertson Investigator
2015: Blavatnik National Award, Finalist (Life Sciences)
Selected Recent Publications
Burneo JG, Sirven JI, Kiesel LW, Vecht CJ, Jehi L, Chung SS, Uhm J, Politsky JM, Chang EF, Husain AM, Tatum WO, Meador KJ, Noe K, Hesdorffer DC, Herman ST, Wiebe S, Engel J Jr, Schrader S, Parko KL, Dichter MA, Kwan P, Kossoff E, Sperling MR. Managing common complex symptomatic epilepsies: tumors and trauma: american epilepsy society - 2012 annual course summary. Epilepsy Curr 2013;13(5):232-5.
Cheng JS, Lim DA, Chang EF, Barbaro NM. A Review of Percutaneous Treatments for Trigeminal Neuralgia. Neurosurgery. 2013 Sep 23. [Epub ahead of print] PubMed PMID: 24064481.
Wang DD, Ouyang D, Englot DJ, Rolston JD, Molinaro AM, Ward M, Chang EF. Trends in surgical treatment for trigeminal neuralgia in the United States of America from 1988 to 2008. J Clin Neurosci 2013;20(11):1538-45.
Englot DJ, Lee AT, Tsai C, Halabi C, Barbaro NM, Auguste KI, Garcia PA, Chang EF. Seizure types and frequency in patients who "fail" temporal lobectomy for intractable epilepsy. Neurosurgery 2013;73(5):838-44.
Wang DD, Deans AE, Barkovich AJ, Tihan T, Barbaro NM, Garcia PA, Chang EF. Transmantle sign in focal cortical dysplasia: a unique radiological entity with excellent prognosis for seizure control. J Neurosurg 2013;118(2):337-44.
Englot DJ, Ouyang D, Wang DD, Rolston JD, Garcia PA, Chang EF. Relationship between hospital surgical volume, lobectomy rates, and adverse perioperative events at US epilepsy centers. J Neurosurg 2013;118(1):169-74.
Chang EF, Wang DD, Perry DW, Barbaro NM, Berger MS. Homotopic organization of right hemisphere essential language sites in right and bilateral cerebral hemispheric dominance. J Neurosurg 2011;114(4):893-902.
Chang EF, Wang DD, Barkovich AJ, Tihan T, Auguste KI, Sullivan JE, Garcia PA, Barbaro NM. Seizure freedom after surgery for malformations of cortical development. Ann Neurol 2011;70(1):151-62.
Englot DJ, Barbaro NM, Berger MS, Chang EF. Predictors of seizure freedom after surgical resection of supratentorial low-grade gliomas. J Neurosurg 2011;115(2):240-4.
Englot DJ, Han SJ, Lawton MT, Chang EF. Predictors of seizure-freedom in the surgical treatment of supratentorial cavernous malformations. Clinical article. J Neurosurg 2011;115(6):1169-74.
Englot DJ, Berger MS, Barbaro NM, Chang EF. Extent of surgical resection predicts seizure freedom in low-grade temporal lobe brain tumors. Neurosurgery 2012;70(4):921-8.
Englot DJ, Berger MS, Barbaro NM, Chang EF. Factors associated with seizure freedom in the surgical resection of glioneuronal tumors. Epilepsia 2012;53(1):51-7.
Englot DJ, Ouyang D, Barbaro NM, Garcia PA, Chang EF. Epilepsy surgery trends in United States, 1990-2008. Neurology 2012;17;78(16):1200-6.
Rolston JD, Englot DJ, Wang DD, Shih T, Chang EF. Comparison of seizure control outcomes and safety of vagus nerve, deep brain, and responsive neurostimulation: evidence from randomized controlled trials. Neurosurg Focus 2012;32(3)E14.
Englot DJ, Ouyang D, Wang DD, Rolston JD, Garcia PA, Chang EF. Relationship between hospital surgical volume, lobectomy rates, and adverse perioperative events at U.S. Epilepsy Centers. J Neurosurg 2013;118(1):169-74.
Wang DD, Deans A, Barkovich AJ, Tihan T, Garcia PA, Barbaro NM, Chang EF. Transmantle sign in cortical dysplasia: a unique radiologic entity with excellent prognosis for seizure-control. J Neurosurg 2013;118(2):337-44.
Chang EF, Clark A, Smith JS, Polley MY, Chang SM, Barbaro NM, McDermott MW, Berger MS. Functional mapping-guided resection of low-grade gliomas in eloquent areas of the brain: improvement of long-term survival. J Neurosurg 2011; 114(3):566-73.
Chang EF, Quigg M, Oh MC, Dillon WP, Ward MM, Laxer KD, Broshek DK, Barbaro NM. Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy. Neurology 2010; 74(2):165-72.
Bouchard KE, Mesgarani N, Johnson K, Chang EF. Functional organization of human sensorimotor cortex for speech articulation. Nature 2013;495(7441):327-32.
Chang EF*, Niziolek C*, Nagarajan SS, Knight RT, Houde JS. Human cortical sensorimotor network underlying feedback control of vocal pitch. PNAS 2013;110(7):2653-8.
Mesgarani N, Chang EF. Selective cortical representation of attended speaker in multi-talker speech perception. Nature 2012; 485(7397):233-6.
Pasley B, David SV, Mesgarani N, Flinker A, Shamma SA, Crone NE, Knight RT, Chang EF. Reconstructing speech from human auditory cortex. PLoS Biology 2012;10(1):e1001251.
Cheung C, Chang EF. Real-time, single-trial mapping of cortical event-related activation. J Neural Eng 2012;9(4):046018.
Chang EF*, Edwards E*, Nagarajan SS, Fogelson N, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT. Cortical spatiotemporal dynamics underlying phonological target detection in humans. J Cog Neurosci 2011;23(6):1437-46.
Chang EF*, Rieger J*, Johnson KD, Berger MS, Barbaro NM, Knight RT. Categorical speech representation in the human superior temporal gyrus. Nat Neurosci 2010;13(11):1428-32.