Edward F. Chang MD

Edward F. Chang MD

Professor of Neurological Surgery and Bowes Biomedical Investigator

Co-Director, Center for Neural Engineering at UC Berkeley and San Francisco

Faculty, Center for Integrative Neuroscience

Faculty, Biological Sciences Graduate Program

Edward Chang MD is Professor of Neurological Surgery at UCSF. Dr. Chang’s clinical expertise is surgical therapies for intractable epilepsy, trigeminal neuralgiapain, hemifacial spasm, and adult brain tumors. He specializes in advanced neurophysiologic brain mapping methods, including awake speech and motor mapping, to safely perform neurosurgical procedures in eloquent areas of the brain. He also specializes in laser thermal ablation to treat epilepsy. Dr. Chang is a New York Stem Cell Foundation - Robertson Investigator. Dr. Chang was awarded the 2015 Blavatnik National Laureate in Life Sciences in 2015.

His groundbreaking work has been featured by the US News and World Report ("Secrets of Your Brain" special issue), San Francisco Magazine, San Francisco Chronicle, New York Times and Wall Street Journal.

Read About Dr. Chang's Current Research ►

Education, Training, and Previous Positions

1997: BA, Amherst College
2004: MD, University of California, San Francisco
2004-2010: Residency, Neurological Surgery, University of California, San Francisco
2008-2009: Fellowship, Cognitive Neurophysiology Helen Wills Neuroscience Institute, University of California, Berkeley

Selected Professional Memberships and Appointments

Congress of Neurological Surgeons
American Association of Neurological Surgeons (Harvey Cushing Society)
Society for Neuroscience

Selected Honors and Awards

2003: Alpha Omega Alpha
2004: UCSF Dean's Prize for Research
2009-13: Pathway to Independence Award (K99/R00 NIH NINDS)
2011: Klingenstein Fellowship Award in the Neurosciences,
2011: Young Investigator Award, Grass Foundation-American Epilepsy Society
2011-16: NIH New Director's Innovation Award (DP2)
2015-20:  New York Stem Cell Foundation - Robertson Investigator
2015: Blavatnik National Award Laureate in Life Sciences
2018: Bowes Biomedical Investigator

Selected Recent Publications

Ramanathan DS, Guo L, Gulati T, Davidson G, Hishinuma AK, Won SJ, Knight RT, Chang EF, Swanson RA, Ganguly K. Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke. Nat Med. 2018 Jun 18. doi: 10.1038/s41591-018-0058-y. [Epub ahead of print] PubMed PMID: 29915259.

Leonard MK, Desai M, Hungate D, Cai R, Singhal NS, Knowlton RC, Chang EF. Direct cortical stimulation of inferior frontal cortex disrupts both speech and music production in highly trained musicians. Cogn Neuropsychol. 2018 May 22:1-9. doi: 10.1080/02643294.2018.1472559. [Epub ahead of print] PubMed PMID: 29786470.

Hamilton LS, Edwards E, Chang EF. A Spatial Map of Onset and Sustained Responses to Speech in the Human Superior Temporal Gyrus. Curr Biol. 2018 Jun 18;28(12):1860-1871.e4. doi: 10.1016/j.cub.2018.04.033. Epub 2018 May 31. PubMed PMID: 29861132.

Chartier J, Anumanchipalli GK, Johnson K, Chang EF. Encoding of Articulatory Kinematic Trajectories in Human Speech Sensorimotor Cortex. Neuron. 2018 May 8. pii: S0896-6273(18)30339-8. doi: 10.1016/j.neuron.2018.04.031. [Epub ahead of print] PubMed PMID: 29779940.

Winkler EA, Rutledge C, Ward M, Tihan T, Sneed PK, Barbaro N, Garcia P, McDermott M, Chang EF. Radiation-induced Cavernous Malformation as a Late Sequelae of Stereotactic Radiosurgery for Epilepsy. Cureus. 2018 Mar 11;10(3):e2308. doi: 10.7759/cureus.2308. PubMed PMID: 29755904; PubMed Central PMCID: PMC5947923.

Shirvalkar P, Veuthey TL, Dawes HE, Chang EF. Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain. Front Comput Neurosci. 2018 Mar 26;12:18. doi: 10.3389/fncom.2018.00018. eCollection 2018. PubMed PMID: 29632482; PubMed Central PMCID: PMC5879131.

Barbaro NM, Quigg M, Ward MM, Chang EF, Broshek DK, Langfitt JT, Yan G, Laxer KD, Cole AJ, Sneed PK, Hess CP, Yu W, Tripathi M, Heck CN, Miller JW, Garcia PA, McEvoy A, Fountain NB, Salanova V, Knowlton RC, Bagić A, Henry T, Kapoor S, McKhann G, Palade AE, Reuber M, Tecoma E. Radiosurgery versus open surgery for mesial temporal lobe epilepsy: The randomized, controlled ROSE trial. Epilepsia. 2018 Mar 30. doi: 10.1111/epi.14045. [Epub ahead of print] PubMed PMID: 29600809.

Chan AY, Rolston JD, Rao VR, Chang EF. Effect of neurostimulation on cognition and mood in refractory epilepsy. Epilepsia Open. 2018 Feb 13;3(1):18-29. doi: 10.1002/epi4.12100. eCollection 2018 Mar. Review. PubMed PMID: 29588984; PubMed Central PMCID: PMC5839311.

Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 Mar 15;555(7696):377-381. doi: 10.1038/nature25975. Epub 2018 Mar 7. PubMed PMID: 29513649.

Conant DF, Bouchard KE, Leonard MK, Chang EF. Human Sensorimotor Cortex Control of Directly Measured Vocal Tract Movements during Vowel Production. J Neurosci. 2018 Mar 21;38(12):2955-2966. doi: 10.1523/JNEUROSCI.2382-17.2018. Epub 2018 Feb 8. PubMed PMID: 29439164; PubMed Central PMCID: PMC5864145.

Khoshkhoo S, Leonard MK, Mesgarani N, Chang EF. Neural correlates of sine-wave speech intelligibility in human frontal and temporal cortex. Brain Lang. 2018 Jan 31. pii: S0093-934X(17)30071-8. doi: 10.1016/j.bandl.2018.01.007. [Epub ahead of print] PubMed PMID: 29397190.

Moses DA, Leonard MK, Chang EF. Real-time classification of auditory sentences using evoked cortical activity in humans. J Neural Eng. 2018 Jun;15(3):036005. doi: 10.1088/1741-2552/aaab6f. Epub 2018 Jan 30. PubMed PMID: 29378977.

Baud MO, Kleen JK, Mirro EA, Andrechak JC, King-Stephens D, Chang EF, Rao VR. Multi-day rhythms modulate seizure risk in epilepsy. Nat Commun. 2018 Jan 8;9(1):88. doi: 10.1038/s41467-017-02577-y. PubMed PMID: 29311566; PubMed Central PMCID: PMC5758806.

Winkler EA, Birk H, Burkhardt JK, Chen X, Yue JK, Guo D, Rutledge WC, Lasker GF, Partow C, Tihan T, Chang EF, Su H, Kim H, Walcott BP, Lawton MT. Reductions in brain pericytes are associated with arteriovenous malformation vascular instability. J Neurosurg. 2018 Jan 5:1-11. doi: 10.3171/2017.6.JNS17860. [Epub ahead of print] PubMed PMID: 29303444.

Chang EF, Kurteff G, Wilson SM. Selective Interference with Syntactic Encoding during Sentence Production by Direct Electrocortical Stimulation of the Inferior Frontal Gyrus. J Cogn Neurosci. 2018 Mar;30(3):411-420. doi: 10.1162/jocn_a_01215. Epub 2017 Dec 6. PubMed PMID: 29211650; PubMed Central PMCID: PMC5819756.

Hamilton LS, Chang DL, Lee MB, Chang EF. Semi-automated Anatomical Labeling and Inter-subject Warping of High-Density Intracranial Recording Electrodes in Electrocorticography. Front Neuroinform. 2017 Oct 31;11:62. doi: 10.3389/fninf.2017.00062. eCollection 2017. PubMed PMID: 29163118; PubMed Central PMCID: PMC5671481.

Muller L, Rolston JD, Fox NP, Knowlton R, Rao VR, Chang EF. Direct electrical stimulation of human cortex evokes high gamma activity that predicts conscious somatosensory perception. J Neural Eng. 2018 Apr;15(2):026015. doi: 10.1088/1741-2552/aa9bf9. PubMed PMID: 29160232.

Wang DD, Deng H, Hervey-Jumper SL, Molinaro AA, Chang EF, Berger MS. Seizure Outcome After Surgical Resection of Insular Glioma. Neurosurgery. 2017 Nov 8. doi: 10.1093/neuros/nyx486. [Epub ahead of print] PubMed PMID: 29126238.

Martin S, Mikutta C, Leonard MK, Hungate D, Koelsch S, Shamma S, Chang EF, Millán JDR, Knight RT, Pasley BN. Neural Encoding of Auditory Features during Music Perception and Imagery. Cereb Cortex. 2017 Oct 27:1-12. doi: 10.1093/cercor/bhx277. [Epub ahead of print] PubMed PMID: 29088345.

Bouchard KE, Bujan AF, Chang EF, Sommer FT. Sparse coding of ECoG signals identifies interpretable components for speech control in human sensorimotor cortex. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:3636-3639. doi: 10.1109/EMBC.2017.8037645. PubMed PMID: 29060686.

Yuxiao Yang, Chang EF, Shanechi MM. Dynamic tracking of non-stationarity in human ECoG activity. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:1660-1663. doi: 10.1109/EMBC.2017.8037159. PubMed PMID: 29060203.

McCarron A, Chavez A, Babiak M, Berger MS, Chang EF, Wilson SM. Connected speech in transient aphasias after left hemisphere resective surgery. Aphasiology. 2017;31(11):1266-1281. doi: 10.1080/02687038.2017.1278740. Epub 2017 Jan 17. PubMed PMID: 29056810; PubMed Central PMCID: PMC5646839.

Rolston JD, Chang EF. Critical Language Areas Show Increased Functional Connectivity in Human Cortex. Cereb Cortex. 2017 Oct 17:1-8. doi: 10.1093/cercor/bhx271. [Epub ahead of print] PubMed PMID: 29045564.

Baud MO, Kleen JK, Anumanchipalli GK, Hamilton LS, Tan YL, Knowlton R, Chang EF. Unsupervised Learning of Spatiotemporal Interictal Discharges in Focal Epilepsy. Neurosurgery. 2017 Oct 10. doi: 10.1093/neuros/nyx480. [Epub ahead of print] PubMed PMID: 29040672.

Chiong W, Leonard MK, Chang EF. Neurosurgical Patients as Human Research Subjects: Ethical Considerations in Intracranial Electrophysiology Research. Neurosurgery. 2017 Jul 22. doi: 10.1093/neuros/nyx361. [Epub ahead of print] PubMed PMID: 28973530; PubMed Central PMCID: PMC5777911.

Tang C, Hamilton LS, Chang EF. Intonational speech prosody encoding in the human auditory cortex. Science. 2017 Aug 25;357(6353):797-801. doi: 10.1126/science.aam8577. PubMed PMID: 28839071.

Rolston JD, Deng H, Wang DD, Englot DJ, Chang EF. Multiple Subpial Transections for Medically Refractory Epilepsy: A Disaggregated Review of Patient-Level Data. Neurosurgery. 2018 May 1;82(5):613-620. doi: 10.1093/neuros/nyx311. PubMed PMID: 28637175; PubMed Central PMCID: PMC5738293.

Rao VR, Leonard MK, Kleen JK, Lucas BA, Mirro EA, Chang EF. Chronic ambulatory electrocorticography from human speech cortex. Neuroimage. 2017 Jun;153:273-282. doi: 10.1016/j.neuroimage.2017.04.008. Epub 2017 Apr 7. PubMed PMID: 28396294; PubMed Central PMCID: PMC5482367.

Wang DD, Raygor KP, Cage TA, Ward MM, Westcott S, Barbaro NM, Chang EF. Prospective comparison of long-term pain relief rates after first-time microvascular decompression and stereotactic radiosurgery for trigeminal neuralgia. J Neurosurg. 2018 Jan;128(1):68-77. doi: 10.3171/2016.9.JNS16149. Epub 2017 Feb 24. PubMed PMID: 28298026.

Pailla T, Jiang W, Dichter B, Chang EF, Gilja V. ECoG data analyses to inform closed-loop BCI experiments for speech-based prosthetic applications. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:5713-5716. doi: 10.1109/EMBC.2016.7592024. PubMed PMID: 28269552.

Jiang W, Pailla T, Dichter B, Chang EF, Gilja V. Decoding speech using the timing of neural signal modulation. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:1532-1535. doi: 10.1109/EMBC.2016.7591002. PubMed PMID: 28268618.

Muller L, Felix S, Shah KG, Kye Lee, Pannu S, Chang EF. Thin-film, high-density micro-electrocorticographic decoding of a human cortical gyrus. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:1528-1531. doi: 10.1109/EMBC.2016.7591001. PubMed PMID: 28268617; PubMed Central PMCID: PMC5789448.

Perry A, Stiso J, Chang EF, Lin JJ, Parvizi J, Knight RT. Mirroring in the Human Brain: Deciphering the Spatial-Temporal Patterns of the Human Mirror Neuron System. Cereb Cortex. 2018 Mar 1;28(3):1039-1048. doi: 10.1093/cercor/bhx013. PubMed PMID: 28137724.

Leonard MK, Baud MO, Sjerps MJ, Chang EF. Perceptual restoration of masked speech in human cortex. Nat Commun. 2016 Dec 20;7:13619. doi: 10.1038/ncomms13619. PubMed PMID: 27996973; PubMed Central PMCID: PMC5187421.

Simonyan K, Ackermann H, Chang EF, Greenlee JD. New Developments in Understanding the Complexity of Human Speech Production. J Neurosci. 2016 Nov 9;36(45):11440-11448. Review. PubMed PMID: 27911747; PubMed Central PMCID: PMC5125211.

Rübel O, Dougherty M, Prabhat, Denes P, Conant D, Chang EF, Bouchard K. Methods for Specifying Scientific Data Standards and Modeling Relationships with Applications to Neuroscience. Front Neuroinform. 2016 Nov 4;10:48. eCollection 2016. PubMed PMID: 27867355; PubMed Central PMCID: PMC5095137.

Rolston JD, Han SJ, Chang EF. Systemic inaccuracies in the National Surgical Quality Improvement Program database: Implications for accuracy and validity for neurosurgery outcomes research. J Clin Neurosci. 2017 Mar;37:44-47. doi: 10.1016/j.jocn.2016.10.045. Epub 2016 Nov 15. PubMed PMID: 27863971.

Muller L, Hamilton LS, Edwards E, Bouchard KE, Chang EF. Spatial resolution dependence on spectral frequency in human speech cortex electrocorticography. J Neural Eng. 2016 Oct;13(5):056013. doi: 10.1088/1741-2560/13/5/056013. Epub 2016 Aug 31. PubMed PMID: 27578414; PubMed Central PMCID: PMC5081035.

Moses DA, Mesgarani N, Leonard MK, Chang EF. Neural speech recognition: continuous phoneme decoding using spatiotemporal representations of human cortical activity. J Neural Eng. 2016 Oct;13(5):056004. doi: 10.1088/1741-2560/13/5/056004. Epub 2016 Aug 3. PubMed PMID: 27484713; PubMed Central PMCID: PMC5031534.

Leonard MK, Cai R, Babiak MC, Ren A, Chang EF. The peri-Sylvian cortical network underlying single word repetition revealed by electrocortical stimulation and direct neural recordings. Brain Lang. 2016 Jul 19. pii: S0093-934X(15)30194-2. doi: 10.1016/j.bandl.2016.06.001. [Epub ahead of print] PubMed PMID: 27450996; PubMed Central PMCID: PMC5790638.

Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2017 Jan 1;80(1):129-139. doi: 10.1227/NEU.0000000000001344. PubMed PMID: 27428784; PubMed Central PMCID: PMC5235998.

Dichter BK, Bouchard KE, Chang EF. Dynamic Structure of Neural Variability in the Cortical Representation of Speech Sounds. J Neurosci. 2016 Jul 13;36(28):7453-63. doi: 10.1523/JNEUROSCI.0156-16.2016. PubMed PMID: 27413155; PubMed Central PMCID: PMC4945665.

Rolston JD, Englot DJ, Knowlton RC, Chang EF. Rate and complications of adult epilepsy surgery in North America: Analysis of multiple databases. Epilepsy Res. 2016 Aug;124:55-62. doi: 10.1016/j.eplepsyres.2016.05.001. Epub 2016 May 18. PubMed PMID: 27259069; PubMed Central PMCID: PMC5260847.

Bouchard KE, Conant DF, Anumanchipalli GK, Dichter B, Chaisanguanthum KS, Johnson K, Chang EF. High-Resolution, Non-Invasive Imaging of Upper Vocal Tract Articulators Compatible with Human Brain Recordings. PLoS One. 2016 Mar 28;11(3):e0151327. doi: 10.1371/journal.pone.0151327. eCollection 2016. PubMed PMID: 27019106; PubMed Central PMCID: PMC4809489.

Hullett PW, Hamilton LS, Mesgarani N, Schreiner CE, Chang EF. Human Superior Temporal Gyrus Organization of Spectrotemporal Modulation Tuning Derived from Speech Stimuli. J Neurosci. 2016 Feb 10;36(6):2014-26. doi: 10.1523/JNEUROSCI.1779-15.2016. PubMed PMID: 26865624; PubMed Central PMCID: PMC4748082.

Voytek B, Kayser AS, Badre D, Fegen D, Chang EF, Crone NE, Parvizi J, Knight RT, D'Esposito M. Oscillatory dynamics coordinating human frontal networks in support of goal maintenance. Nat Neurosci. 2015 Sep;18(9):1318-24. doi: 10.1038/nn.4071. Epub 2015 Jul 27. PubMed PMID: 26214371; PubMed Central PMCID: PMC4551604.

Cibelli ES, Leonard MK, Johnson K, Chang EF. The influence of lexical statistics on temporal lobe cortical dynamics during spoken word listening. Brain Lang. 2015 Aug;147:66-75. doi: 10.1016/j.bandl.2015.05.005. Epub 2015 Jun 11. PubMed PMID: 26072003; PubMed Central PMCID: PMC4521602.

Leonard MK, Bouchard KE, Tang C, Chang EF. Dynamic encoding of speech sequence probability in human temporal cortex. J Neurosci. 2015 May 6;35(18):7203-14. doi: 10.1523/JNEUROSCI.4100-14.2015. PubMed PMID: 25948269; PubMed Central PMCID: PMC4420784.

Nahum M, Van Vleet TM, Sohal VS, Mirzabekov JJ, Rao VR, Wallace DL, Lee MB, Dawes H, Stark-Inbar A, Jordan JT, Biagianti B, Merzenich M, Chang EF. Immediate Mood Scaler: Tracking Symptoms of Depression and Anxiety Using a Novel Mobile Mood Scale. JMIR Mhealth Uhealth. 2017 Apr 12;5(4):e44. doi: 10.2196/mhealth.6544. PubMed PMID: 28404542; PubMed Central PMCID: PMC5406620.