Michael S. Beattie PhD

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• Professor in Residence of Neurological Surgery

• Principal Investigator, Brain and Spinal Injury Center









Dr. Beattie has been interested in the neural mechanisms of recovery after brain and spinal cord injury for many years. He and his wife and collaborator, Dr. Jacqueline Bresnahan (also a member of the Neurosurgery faculty), have recently moved their laboratory to the Brain and Spinal Injury Center (BASIC) at UCSF from Ohio State University. Their group is known for developing preclinical models to study recovery of function after spinal cord injury, and for studies of the biology of neural injury and repair. Current projects include analyses of the interrelationship of post-injury inflammatory events and excitotoxic cell death, the roles of oligodendrocyte death and replacement in recovery after injury, and the development of stem and progenitor cell transplantation strategies for promoting recovery after spinal cord injury. The laboratory continues to develop new animal paradigms for modeling human neurotrauma. BASIC's location at the SFGH along with the physician-scientists of UCSF Neurotrauma program will promote basic and clinical science interactions, and new animal models will be generated based on knowledge of current treatments and outcomes in the human neurotrauma arena. For example, there is an emerging interest in post injury edema, studied in rodents using high field MR imaging. Acute studies of interventions that can reduce edema in animal studies may be taken directly to clinical studies in the neurotrauma ICU. Dr. Beattie's goal is to help translate the laboratory's expertise in the biology of injury and recovery to treatments that can be implemented and tested in neurotrauma patients at SFGH and other centers.

Education, Training, and Previous Positions

1972: BS, University of California, Davis
1974: MA, Ohio State University
1977: PhD, Ohio State University
1977-1978: NIH Postdoctoral Fellow, Neuropsychology/Neuroanatomy, Ohio State University
1978-1979: Postdoctoral Fellow, Neuroanatomy, Michigan State University
1979-1985: Assistant Professor, Neurosurgery and Anatomy, Ohio State University
1985-1992: Associate Professor, Neurosurgery, Neurobiology, Anatomy and Cell Biology, Ohio State University
1992-1999: Professor, Neurosurgery, Neurobiology, Anatomy and Cell Biology, Ohio State University
1999-2002: Professor and Interim Chair, Neuroscience, Ohio State University
2002-2006: Professor and Chair, Neuroscience, Ohio State University
2006-Present: Department of Neurological Surgery, UCSF

Selected Professional Memberships and Appointments

Society for Neuroscience
National Neurotrauma Society
International Neurotrauma Society (Founding Member)
Inernational Society for Stem Cell Research

Selected Honors and Awards

1979: National Research Service Award, Individual NIH Fellowship
1994: Knight Lecture in Neuroscience, University of Miami
1997: Rudolf Magnus Lecture, Utrecht University
2000: John D. and E. Olive Brumbaugh Chair of Brain Research and Teaching

Selected Recent Publications

Downing TL, Wang A, Yan ZQ, Nout Y, Lee AL, Beattie MS, Bresnahan JC, Farmer DL, Li S. Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. J Control Release 2012;161(3):910-917.

Stück ED, Christensen RN, Huie JR, Tovar CA, Miller BA, Nout YS, Bresnahan JC, Beattie MS, Ferguson AR. Tumor necrosis factor alpha mediates GABA(A) receptor trafficking to the plasma membrane of spinal cord neurons in vivo. Neural Plast 2012;2012:261345.

Gensel JC, Tovar CA, Bresnahan JC, Beattie MS. Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury. PLoS One 2012;7(3):e33519.

Nout YS, Rosenzweig ES, Brock JH, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Courtine G, Ferguson AR, Edgerton VR, Beattie MS, Bresnahan JC, Tuszynski MH. Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury. Neurotherapeutics 2012;9(2):380-92.

Sorani MD, Beattie MS, Bresnahan JC. A Quantitative Analysis of Clinical Trial Designs in Spinal Cord Injury Based on ICCP Guidelines. J Neurotrauma 2012;29(9):1736-46.

Nout YS, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Zhong H, Rosenzweig ES, Brock JH, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC. Methods for Functional Assessment After C7 Spinal Cord Hemisection in the Rhesus Monkey. Neurorehabil Neural Repair. 2012 Feb 13. [Epub ahead of print].

Saadai P, Nout YS, Encinas J, Wang A, Downing TL, Beattie MS, Bresnahan JC, Li S, Farmer DL. Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds-a pilot study in sheep. J Pediatr Surg 2011;46(12):2279-83.

Bresnahan JC, Beattie MS. Spinal cord injury: taking a detour to recovery (Commentary on Schnell et al.). Eur J Neurosci 2011;34(8):1254-5.

Veiga S, Ly J, Chan PH, Bresnahan JC, Beattie MS. SOD1 overexpression improves features of the oligodendrocyte precursor response in vitro. Neurosci Lett 2011;503(1):10-4.

Beattie MS, Manley GT. Tight squeeze, slow burn: inflammation and the aetiology of cervical myelopathy. Brain 2011;134(Pt 5):1259-61.

Nout YS, Beattie MS, Bresnahan JC. Severity of locomotor and cardiovascular derangements after experimental high-thoracic spinal cord injury is anesthesia dependent in rats. J Neurotrauma 2012;29(5):990-9.

Irvine KA, Ferguson AR, Mitchell KD, Beattie SB, Beattie MS, Bresnahan JC. A novel method for assessing proximal and distal forelimb function in the rat: the Irvine, Beatties and Bresnahan (IBB) forelimb scale. J Vis Exp 2010;(46). pii: 2246.

Rosenzweig ES, Courtine G, Jindrich DL, Brock JH, Ferguson AR, Strand SC, Nout YS, Roy RR, Miller DM, Beattie MS, Havton LA, Bresnahan JC, Edgerton VR, Tuszynski MH. Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nat Neurosci 2010;13(12):1505-10.

Nout YS, Culp E, Schmidt MH, Tovar CA, Pröschel C, Mayer-Pröschel M, Noble MD, Beattie MS, Bresnahan JC. Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats. Exp Neurol 2011;227(1):159-71.

Beattie MS, Ferguson AR, Bresnahan JC. AMPA-receptor trafficking and injury-induced cell death. Eur J Neurosci 2010;32(2):290-7.

Sun F, Lin CL, McTigue D, Shan X, Tovar CA, Bresnahan JC, Beattie MS. Effects of axon degeneration on oligodendrocyte lineage cells: dorsal rhizotomy evokes a repair response while axon degeneration rostral to spinal contusion induces both repair and apoptosis. Glia 2010;58(11):1304-19.

Kwon BK, Okon EB, Tsai E, Beattie MS, Bresnahan JC, Magnuson DK, Reier PJ, McTigue DM, Popovich PG, Blight AR, Oudega M, Guest JD, Weaver LC, Fehlings MG, Tetzlaff W. A grading system to evaluate objectively the strength of pre-clinical data of acute neuroprotective therapies for clinical translation in spinal cord injury. J Neurotrauma 2011;28(8):1525-43.

Nout YS, Mihai G, Tovar CA, Schmalbrock P, Bresnahan JC, Beattie MS. Hypertonic saline attenuates cord swelling and edema in experimental spinal cord injury: a study utilizing magnetic resonance imaging. Crit Care Med 2009;37(7):2160-6.

Ferguson AR, Christensen RN, Gensel JC, Miller BA, Sun F, Beattie EC, Bresnahan JC, Beattie MS.Cell death after spinal cord injury is exacerbated by rapid TNF alpha-induced trafficking of GluR2-lacking AMPARs to the plasma membrane. J Neurosci 2008;28(44):11391-400.
 
Mihai G, Nout YS, Tovar CA, Miller BA, Schmalbrock P, Bresnahan JC, Beattie MS. Longitudinal comparison of two severities of unilateral cervical spinal cord injury using magnetic resonance imaging in rats. J Neurotrauma 2008;25(1):1-18.
 
Miller BA, Crum JM, Tovar CA, Ferguson AR, Bresnahan JC, Beattie MS. Developmental stage of oligodendrocytes determines their response to activated microglia in vitro. J Neuroinflammation 2007;4:28.
 
Nout YS, Bresnahan JC, Culp E, Tovar CA, Beattie MS, Schmidt MH. Novel technique for monitoring micturition and sexual function in male rats using telemetry. Am J Physiol Regul Integr Comp Physiol 2007;292(3):R1359-67.
 
Christensen RN, Ha BK, Sun F, Bresnahan JC, Beattie MS. Kainate induces rapid redistribution of the actin cytoskeleton in ameboid microglia. J Neurosci Res 2006;84(1):170-81.
 
Gensel JC, Tovar CA, Hamers FP, Deibert RJ, Beattie MS, Bresnahan JC. Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats. J Neurotrauma 2006;23(1):36-54.
 
Miller BA, Sun F, Christensen RN, Ferguson AR, Bresnahan JC, Beattie MS. A sublethal dose of TNFalpha potentiates kainate-induced excitotoxicity in optic nerve oligodendrocytes. Neurochem Res 2005;30(6-7):867-75.
 
Beattie MS. Inflammation and apoptosis: linked therapeutic targets in spinal cord injury. Trends Mol Med 2004;10(12):580-3.
 
Hill CE, Proschel C, Noble M, Mayer-Proschel M, Gensel JC, Beattie MS, Bresnahan JC. Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration. Exp Neurol 2004;190(2):289-310.
 
Beattie MS, Harrington AW, Lee R, Kim JY, Boyce SL, Longo FM, Bresnahan JC, Hempstead BL, Yoon SO. ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron 2002;36(3):375-86.
 
Beattie EC, Stellwagen D, Morishita W, Bresnahan JC, Ha BK, Von Zastrow M, Beattie MS, Malenka RC. Control of synaptic strength by glial TNFalpha. Science. 2002 Mar 22;295(5563):2282-5.
 
Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 1997;3(1):73-6. Erratum in: Nat Med 1997;3(2):240.