Scott Baraban PhD

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• Professor in Residence of Neurological Surgery
• William K. Bowes Jr. Endowed Chair in Neuroscience Research
• Faculty Member, PIBS Graduate Program in Neuroscience
• Faculty Member, Biomedical Sciences Graduate Program
• Faculty Member, Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research

 

Dr. Baraban's laboratory has active research projects on epilepsy associated with a malformed brain; seizures and seizure resistance in zebrafish; and anticonvulsant strategies using neural progenitor cells.

Read about Dr. Baraban's current research ►

Education, Training, and Previous Positions

1987: BA, Johns Hopkins University
1994: PhD, University of Virginia
1994-1997: Postdoctoral Fellow, University of Washington, Department of Neurological Surgery
1996-1997: Postdoctoral Fellow, University of Washington, Howard Hughes Medical Institute
1997-1999: Assistant Professor, Case Western Reserve University, Departments of Pediatrics (primary appointment) and Neuroscience (secondary appointment)
1999-Present: Department of Neurological Surgery, UCSF

Selected Professional Memberships and Appointments

Society for Neuroscience
American Epilepsy Society

Selected Honors and Awards

1995: American Epilepsy Society and Milken Family Foundation, Postdoctoral Research Fellowship
1998: Epilepsy Foundation of America, Junior Investigator Research Award
1999: March of Dimes Foundation, Basil O'Connor Starter Scholar Award
2000: Sandler Family Supporting Foundation, UCSF Innovation in Basic Science Award
2001: Symposium Faculty, 21st Merritt-Putnam Symposium (Epilepsy and Disorders of Brain Development)
2003: Esther and Joseph Klingenstein Fund, Fellowship Award in Neuroscience

Selected Recent Publications

Baraban SC, Southwell DG, Estrada RC, Jones DL, Sebe JY, Alfaro-Cervello C, García-Verdugo JM, Rubenstein JL, Alvarez-Buylla A. Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. Proc Natl Acad Sci U S A. 2009;106(36):15472-7. doi: 10.1073/pnas.0900141106

Greenwood JS, Wang Y, Estrada RC, Ackerman L, Ohara PT, Baraban SC. Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant mice. Ann Neurol 2009;66(5):644-53.

Battaglia G, Becker AJ, LoTurco J, Represa A, Baraban SC, Roper SN, Vezzani A. Basic mechanisms of MCD in animal models. Epileptic Disord 2009;11(3):206-14.

Jones DL, Baraban SC. Jones DL, Baraban SC. Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice. J Neurophysiol 2009;102(2):648-58.

Wang Y, Baraban SC. Aberrant dentate gyrus cytoarchitecture and fiber lamination in Lis1 mutant mice. Hippocampus 2008;18(8):758-65.

Richardson RM, Barbaro NM, Alvarez-Buylla A, Baraban SC. Developing cell transplantation for temporal lobe epilepsy [review]. Neurosurg Focus 2008;24(3-4):E17.

Jones DL, Baraban SC. Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice. J Neurophysiol 2007;98(5):2737-46.
 
Baraban SC, Dinday MT, Castro PA, Chege S, Guyenet S, Taylor MR. A large-scale mutagenesis screen to identify seizure-resistant zebrafish. Epilepsia 2007;48(6):1151-7.
 
Baraban SC. Emerging epilepsy models: insights from mice, flies, worms and fish [Review]. Curr Opin Neurol 2007;20(2):164-8.
 
Wang Y, Greenwood JS, Calcagnotto ME, Kirsch HE, Barbaro NM, Baraban SC. Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1. Ann Neurol 2007;61(2):139-52.
 
Harrington EP, Möddel G, Najm IM, Baraban SC. Altered glutamate receptor - transporter expression and spontaneous seizures in rats exposed to methylazoxymethanol in utero. Epilepsia 2007;48(1):158-68.
 
Wang Y, Baraban SC. Granule cell dispersion and aberrant neurogenesis in the adult hippocampus of an LIS1 mutant mouse. Dev Neurosci 2007;29(1-2):91-8.
 
Paredes MF, Li G, Berger O, Baraban SC, Pleasure SJ. Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains. J Neurosci 2006;26(37):9404-12.
 
Alvarez-Dolado M, Calcagnotto ME, Karkar KM, Southwell DG, Jones-Davis DM, Estrada RC, Rubenstein JL, Alvarez-Buylla A, Baraban SC. Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. J Neurosci 2006;26(28):7380-9.
 
Wang Y, Barbaro MF, Baraban SC. A role for the mTOR pathway in surface expression of AMPA receptors. Neurosci Lett 2006;401(1-2):35-9.
 
Paredes M, Pleasure SJ, Baraban SC. Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia. J Comp Neurol 2006;495(1):133-48.
 
Baraban SC, Taylor MR, Castro PA, Baier H. Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience 2005;131(3):759-68.
 
Barbaro NM, Takahashi DK, Baraban SC. A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro. Neuroscience 2004;128(3):655-63.
 
Calcagnotto ME, Paredes M, Baraban SC. Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy. J Neurosci 2002;22(17):7596-605.
 
Castro PA, Cooper EC, Lowenstein DH, Baraban SC. Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy. J Neurosci 2001;21(17):6626-34.