Videos

3D Reconstructions and Renderings

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3D Reconstruction of the MRI scans of Gracie, our dog patient, with infusions for brain cancer colored red
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MRI 3D reconstruction: cortical (yellow) and brain stem (red) regions were infused with MRI contrast liposomes by CED technique
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3D Reconstruction of AAV2-AADC infusions into the putamen: entire MRI cut-away rotated to reveal the putamen (red) within. This and similar work allowed us to optimize AADC gene transfer in PD patients.
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3D rendering of our Convection-Enhanced Delivery method: access port attached to skull, cannula aimed at target structure (red), infusion fills target structure (grey), and access port closed. Animation created by John Doval (UCD).

MRI-Visible Infusions

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MRI video of real-time infusions of liposomes into a different region of the brain: the brainstem
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MRI video of brain tumor therapy (liposomal CPT-11) infused into Gunnar, another dog patient. The tumor is at the lower left.
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Example of MRI-guided AAV delivery into the brain: MRI video of AAV2-GFP with the infusion (white) and an overlay of GFP expression (black) showing overlap of delivery and expression
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Second MRI video: AAV2-AADC infusion (white) and an overlay of AADC expression (black) showing overlap of delivery and expression
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MRI video of brain tumor therapy (liposomal CPT-11) infused into Gracie's tumor.
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Post-surgery video of Gracie, running and frolicking a day after receiving CED treatment.


Cannula Tests

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Modeling of convection-enhanced delivery in an agarose gel: standard cannula (left) shows reflux upwards, but our step cannula (right) delivers dye at the cannula tip without reflux.
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Example of reflux (right gel) with an unmodified cannula unsuitable for CED. No reflux is observed with our CED cannulae as shown in the middle and left agarose gels.