Peer-reviewed articles

2016

  1. Salegio EA, Bringas J, Bankiewicz KS.MRI-Guided Delivery of Viral Vectors. Methods Mol Biol. 2016;1382:217-30.
  2. Samaranch L, Bringas J, Pivirotto P, San Sebastian W, Forsayeth J, Bankiewicz K. Cerebellomedullary cistern delivery for AAV-based Gene therapy: A technical note for non-human primates. Hum Gene Ther Methods. 2016 Jan 12.
  3. Rowland NC, Kalia SK, Kalia LV, Larson PS, Lim DA, Bankiewicz KS. Merging DBS with viral vector or stem cell implantation: "hybrid" stereotactic surgery as an evolution in the surgical treatment of Parkinson's disease. Mol Ther Methods Clin Dev. 2016 Jan 13;3:15051

2015

  1. Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW. GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. Exp Neurol. 2015 Jan;263:177-89
  2. Ciesielska A, Sharma N, Beyer J, Forsayeth J, Bankiewicz K. Carbidopa-based modulation of the functional effect of the AAV2-hAADC gene therapy in 6-OHDA lesioned rats. PLoS One. 2015 Apr 10;10(4)
  3. Forsayeth J, Bankiewicz KS. Transduction of antigen-presenting cells in the brain by AAV9 warrants caution in preclinical studies. Mol Ther. 2015 Apr;23(4):612.
  4. Seo JW, Ang J, Mahakian LM, Tam S, Fite B, Ingham ES, Beyer J, Forsayeth J, Bankiewicz KS, Xu T, Ferrara KW. Self-assembled 20-nm (64)Cu-micelles enhance accumulation in rat glioblastoma. J Control Release. 2015 Dec 28;220
  5. Samaranch L, Hadaczek P, Kells AP, Bringas JR, Stockinger D, San Sebastian W, Macayan M, Samineni S, Pivirotto P, Forsayeth J, Bankiewicz KS. Slow AAV2 clearance from the brain of nonhuman primates and anti-capsid immune response. Gene Ther. 2015 Aug 23.

2014

  1. Passini MA, Bu J, Richards AR, Treleaven CM, Sullivan JA, O'Riordan CR, Scaria A, Kells AP, Samaranch L, San Sebastian W, Federici T, Fiandaca MS, Boulis NM, Bankiewicz K, Shihabuddin LS, Cheng SH.
    Translational Fidelity of Intrathecal Delivery of scAAV9-SMN1 for Spinal Muscular Atrophy. Hum Gene Ther.
  2. Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW.
    Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors. Nanomedicine (Lond).
  3. Ryapolova-Webb E, Afshar P, Stanslaski S, Denison T, de Hemptinne C, Bankiewicz K, Starr PA.
    Chronic cortical and electromyographic recordings from a fully implantable device: preclinical experience in a nonhuman primate. J Neural Eng.
  4. Samaranch L, Sebastian WS, Kells AP, Salegio EA, Heller G, Bringas JR, Pivirotto P, Dearmond S, Forsayeth J, Bankiewicz KS.
    AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction. Mol Ther.
  5. Park I, Larson PE, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ.
    Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain. Magn Reson Med.
  6. Dube N, Shu JY, Dong H, Seo JW, Ingham E, Kheirolomoom A, Chen PY, Forsayeth J, Bankiewicz K, Ferrara KW, Xu T.
    Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers. Biomacromolecules.
  7. Park I, Larson PE, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ. Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain. Magn Reson Med. 2014 Jan;71(1):19-25.
  8. Samaranch L, Sebastian WS, Kells AP, Salegio EA, Heller G, Bringas JR, Pivirotto P, Dearmond S, Forsayeth J, Bankiewicz KS. AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction. Mol Ther. 2014 Feb;22(2):329-37.
  9. Ryapolova-Webb E, Afshar P, Stanslaski S, Denison T, de Hemptinne C, Bankiewicz K, Starr PA. Chronic cortical and electromyographic recordings from a fully implantable device: preclinical experience in a nonhuman primate. J Neural Eng. 2014 Jan 20;11(1)
  10. Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW. Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors. Nanomedicine (Lond). 2014 Jul;9(14):2099-108
  11. Ernesto A Salegio, Hillary Streeter, Nikhil Dube, Lluis Samaranch, Adrian Kells, Waldy San Sebastián, John Bringas, Ting Xu, John Forsayeth, Krystof S Bankiewicz. Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy. Front Neuroanat. 2014; 8: 9. Published online 2014 March 17
  12. Ahn M, Bajsarowicz K, Oehler A, Lemus A, Bankiewicz K, DeArmond SJ. Convection-Enhanced Delivery of AAV2-PrPshRNA in Prion-Infected Mice. PLoS One. 2014 May 27;9(5)
  13. Yang X, Saito R, Nakamura T, Zhang R, Sonoda Y, Kumabe T, Forsayeth J, Bankiewicz K, Tominaga T. Peri-tumoral leakage during intra-tumoral convection-enhanced delivery has implications for efficacy of peri-tumoral infusion before removal of tumor. Drug Deliv. 2014 May 28:1-6.
  14. Barak S, Wang J, Ahmadiantehrani S, Ben Hamida S, Kells AP, Forsayeth J, Bankiewicz KS, Ron D. Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse. Addict Biol. 2014 May 6.
  15. Burnett R, Ibanez CE, Pettersson PL, Chen CI, Parab S, Huang T, Robbins J, Bankiewicz KS, Aghi M, Logg C, Kasahara N, Pertschuk D, Gruber HE, Jolly DJ. Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids. Molecular Therapy — Methods & Clinical Development (2014) 1, 14024
  16. Joniec-Maciejak I, Ciesielska A, Wawer A, Sznejder-Pachołek A, Schwenkgrub J, Cudna A, Hadaczek P, Bankiewicz KS, Członkowska A, Członkowski A. The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease. Pharmacol Rep. 2014 Aug;66(4):660-9.
  17. Passini MA, Bu J, Richards AM, Treleaven CM, Sullivan JA, O'Riordan CR, Scaria A, Kells AP, Samaranch L, San Sebastian W, Federici T, Fiandaca MS, Boulis NM, Bankiewicz KS, Shihabuddin LS, Cheng SH. Translational fidelity of intrathecal delivery of self-complementary AAV9-survival motor neuron 1 for spinal muscular atrophy. Hum Gene Ther. 2014 Jul;25(7):619-30

2013

  1. Samaranch L, Salegio EA, San Sebastian W, Kells AP, Bringas JR, Forsayeth J, Bankiewicz KS.
    Strong Cortical and Spinal Cord Transduction After AAV7 and AAV9 Delivery Into the Cerebrospinal Fluid of Nonhuman Primates. Hum Gene Ther.
  2. Rosenbluth KH, Martin AJ, Mittermeyer S, Eschermann J, Dickinson PJ,Bankiewicz KS.
    Rapid inverse planning for pressure-driven drug infusions in the brain. PLoS One.
  3. Levine ND, Rademacher DJ, Collier TJ, O'Malley JA, Kells AP, San Sebastian W, Bankiewicz KS, Steece-Collier K.
    Advances in thin tissue Golgi-Cox impregnation: fast, reliable methods for multi-assay analyses in rodent and non-human primate brain. J Neurosci Methods.
  4. Ciesielska A, Hadaczek P, Mittermeyer G, Zhou S, Wright JF, Bankiewicz KS, Forsayeth J.
    Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses. Mol Ther.

2012

  1. Rosenbluth KH, Martin AJ, Bringas J, Bankiewicz KS.
    Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 Tesla MRI. J Magn Reson Imaging.
  2. Bu J, Ashe KM, Bringas J, Marshall J, Dodge JC, Cabrera-Salazar MA, Forsayeth J, Schuchman EH, Bankiewicz KS, Cheng SH, Shihabuddin LS, Passini MA.
    Merits of combination cortical, subcortical, and cerebellar injections for the treatment of Niemann-Pick disease type A. Mol Ther.
  3. Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, Sebastian WS, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J.
    Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain. Hum Gene Ther.
  4. Mittermeyer G, Christine CW, Rosenbluth KH, Baker SL, Starr P, Larson P, Kaplan PL, Forsayeth J, Aminoff MJ, Bankiewicz KS.
    Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease. Hum Gene Ther.
  5. Salegio EA, Samaranch L, Kells AP, Mittermeyer G, San Sebastian W, Zhou S, Beyer J, Forsayeth J, Bankiewicz KS.
    Axonal transport of adeno-associated viral vectors is serotype-dependent. Gene Ther.
  6. Mendiburu-Elicabe M, Yin D, Hadaczek P, Zhai Y, Forsayeth J, Bankiewicz KS.
    Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study. J Neurooncol.
  7. Samaranch L, Salegio EA, San Sebastian W, Kells AP, Foust KD, Bringas JR, Lamarre C, Forsayeth J, Kaspar BK, Bankiewicz KS.
    Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates. Hum Gene Ther.
  8. Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS.
    Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. PLoS One.
  9. Fiandaca MS, Berger MS, Bankiewicz KS. The use of convection-enhanced delivery with liposomal toxins in neurooncology. Toxins (Basel). Kells AP, Forsayeth J, Bankiewicz KS.
    Glial-derived neurotrophic factor gene transfer for Parkinson's disease: anterograde distribution of AAV2 vectors in theprimate brain. Neurobiol Dis.
  10. Kells AP, Forsayeth J, Bankiewicz KS.
    Glial-derived neurotrophic factor gene transfer for Parkinson's disease: anterograde distribution of AAV2 vectors in theprimate brain. Neurobiol Dis.
  11. San Sebastian W, Richardson RM, Kells AP, Lamarre C, Bringas J, Pivirotto P, Salegio EA, Dearmond SJ, Forsayeth J, Bankiewicz KS.
    Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum. Hum Gene Ther.
  12. Rosenbluth KH, Eschermann JF, Mittermeyer G, Thomson R, Mittermeyer S, Bankiewicz KS.
    Analysis of a simulation algorithm for direct brain drug delivery. Neuroimage.

2011

  1. Forsayeth JR, Bankiewicz KS.
    AAV9: over the fence and into the woods Mol Ther.
  2. Khodr CE, Sapru MK, Pedapati J, Han Y, West NC, Kells AP, Bankiewicz KS, Bohn MC.
    An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons. Brain Res.
  3. Richardson RM, Kells AP, Martin AJ, Larson PS, Starr PA, Piferi PG, Bates G, Tansey L, Rosenbluth KH, Bringas JR, Berger MS, Bankiewicz KS.
    Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain. Stereotact Funct Neurosurg.
  4. Richardson RM, Gimenez F, Salegio EA, Su X, Bringas J, Berger MS, Bankiewicz KS.
    T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery. Neurosurgery.
  5. Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS.
    Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease. Mol Ther.
  6. Rosenbluth KH, Luz M, Mohr E, Mittermeyer S, Bringas J, Bankiewicz KS.
    Design of an in-dwelling cannula for convection-enhanced delivery. J Neurosci Methods.
  7. Fiandaca MS, Salegio EA, Yin D, Richardson RM, Valles FE, Larson PS, Starr PA, Lonser RR, Bankiewicz KS.
    Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements. J Neurosci Methods.
  8. Laganiere J, Kells AP, Lai JT, Guschin D, Paschon DE, Meng X, Fong LK, Yu Q, Rebar EJ, Gregory PD, Bankiewicz KS, Forsayeth J, Zhang HS.
    An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease. J Neurosci.
  9. Ciesielska A, Mittermeyer G, Hadaczek P, Kells AP, Forsayeth J, Bankiewicz KS.
    Anterograde axonal transport of AAV2-GDNF in rat basal ganglia. Mol Ther.

2010

  1. Aguilar Salegio EA, Kells AP, Richardson M, Hadaczek P, Forsayeth J, Bringas J, Sardi P, Passini MA, Shihabuddin LS, Cheng SH, Fiandaca MS, Bankiewicz K.
    MRI-guided delivery of AAV2 to the primate brain for the treatment of lysosomal storage disorders. Hum Gene Ther.
  2. Yin D, Forsayeth J, Bankiewicz KS. (2010)
    Optimized cannula design and placement for convection-enhanced delivery in rat striatum.
  3. Yin D, Richardson RM, Fiandaca MS, Bringas J, Forsayeth J, Berger MS, Bankiewicz KS (2010)
    Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics. Journal of Neurosurgery.
  4. Martínez-Cerdeño V, Noctor SC, Espinosa A, Ariza J, Parker P, Orasji S, Daadi MM, Bankiewicz K, Alvarez-Buylla A, Kriegstein AR (2010)
    Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats. Cell Stem Cell.
  5. Gimenez F, Krauze MT, Valles F, Hadaczek P, Bringas J, Sharma N, Forsayeth J, Bankiewicz KS (2010)
    Image-guided convection-enhanced delivery of GDNF protein into monkey putamen. NeuroImage.
  6. Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS (2010)
    Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology.
  7. Valles F, Fiandaca MS, Eberling JL, Starr PA, Larson PS, Christine CW, Forsayeth J, Richardson MR, Su X, Aminoff MJ, Bankiewicz KS. (2010)
    Qualitative Imaging of AAV2-hAADC Gene Therapy in a Phase I Study for the Treatment of Parkinson's Disease. Neurosurgery
  8. Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. (2010)
    Regeneration of the MPTP-lesioned Dopaminergic System after Convection-enhanced Delivery of AAV2-GDNF. Journal of Neuroscience.
  9. Aguilar-Salegio E, Kells AP, Richardson RM, Hadaczek P, Forsayeth J, Bringas J, Sardi PS, Passini M, Shihabuddin L, Fiandaca MS, Bankiewicz KS. (2010)
    MRI-controlled delivery of AAV2 to the primate brain for the treatment of lysosomal storage disorders. Human Gene Therapy.
  10. Su X, Kells AP, Aguilar-Salegio A, Richardson M, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS. (2010)
    MRI Predicts Distribution of GDNF in the NHP Brain After Convection-enhanced Delivery of AAV2-GDNF. Molecular Therapy.
  11. Hadaczek P, Eberling JL, Pivirotto P, Bringas J, Forsayeth J, Bankiewicz KS. (2010)
    Eight Years of Clinical Improvement in MPTP-lesioned Primates After Gene Therapy With AAV2-hAADC. Molecular Therapy.

2009

  1. Dickinson, PJ, LeCouteur RA, Higgins RJ, Bringas JR, Roberts B, Larson, RF, Yamashita, Y, Krauze, MT, Noble, CO, Drummond, D, Kirpotin, DB, Park, JW, Mitchel S Berger, MB, Bankiewicz KS.(2009)
    Canine spontaneous glioma: A translational model system for convection-enhanced delivery. NeuroOncology
  2. Yin D, Forsayeth J, Bankiewicz KS. (2009)
    Optimized cannula design and placement for convection-enhanced delivery in rat striatum. J Neurosci methods.
  3. Krauze MT, Forsayeth J, Yin D, Bankiewicz KS. (2009)
    Convection-enhanced delivery of liposomes to primate brain. Methods Enzymol.
  4. Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ. (2009)
    Safety and tolerability of putaminal AADC gene therapy for Parkinson disease. Neurology.
  5. Yin D, Valles FE, Fiandaca MS, Bringas J, Gimenez F, Berger MS, Forsayeth J, Bankiewicz KS. (2009)
    Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates. Neuroimage.
  6. Valles F, Fiandaca MS, Bringas J, Dickinson P, LeCouteur R, Higgins R, Berger M, Forsayeth J, Bankiewicz KS. (2009)
    Anatomic compression caused by high-volume convection-enhanced delivery to the brain. Neuroimage.
  7. Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS. (2009)
    Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Hum Gene Ther.
  8. Varenika V, Kells AP, Valles F, Hadaczek P, Forsayeth J, Bankiewicz KS. (2009)
    Controlled dissemination of AAV vectors in the primate brain. Prog Brain Res.
  9. Richardson RM, Varenika V, Forsayeth JR, Bankiewicz KS. (2009)
    Future applications: gene therapy. Prog Brain Res.
  10. Grahn AY, Bankiewicz KS, Dugich-Djordjevic M, Bringas JR, Hadaczek P, Johnson GA, Eastman S, Luz M. (2009)
    Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience. J Neurooncol.
  11. Hadaczek P, Forsayeth J, Mirek H, Munson K, Bringas J, Pivirotto P, McBride JL, Davidson BL, Bankiewicz KS. (2009)
    Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response. Hum Gene Ther.
  12. Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ, Forsayeth J, Bankiewicz KS. (2009)
    Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys. Hum Gene Ther.
  13. Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS. (2009)
    Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Hum Gene Ther.
  14. Kells AP, Hadaczek P, Yin D, Bringas J, Varenika V, Forsayeth J, Bankiewicz KS. (2009)
    Efficient gene therapy-based method for the delivery of therapeutics to primate cortex. Proc Natl Acad Sci U S A.
  15. Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. (2009)
    Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage.
  16. Yin, D., F. E. Valles, et al. (2009).
    Striatal volume differences between non-human and human primates." J Neurosci Methods 176(2): 200-5.

2008

  1. Dickinson, PJ, LeCouteur RA, Higgins RJ, Bringas JR, Roberts B, Larson, RF, Yamashita, Y, Krauze, MT, Noble, CO, Drummond, D, Kirpotin, DB, Park, JW, Mitchel S Berger, MB, Bankiewicz KS., 2008.
    Convection enhanced delivery of liposomes containing CPT-11 monitored with real time magnetic resonance imaging in a canine large animal model system. Journal of Neurosurgery.
  2. Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, and Michael J. Aminoff MJ., 2008.
    Results from a Phase I Safety Trial of hAADC Gene Therapy for Parkinson's Disease. Neurology.
  3. Fiandaca, M. S., V. Varenika, et al. (2008).
    "Real-time MR imaging of adeno-associated viral vector delivery to the primate brain." Neuroimage.
  4. Fiandaca, M., Forsayeth, J., and Bankiewicz, K., 2008.
    Current status of gene therapy trials for Parkinson's disease. Exp Neurol 209, 51-57
  5. Fiandaca, M. S., Forsayeth, J. R., Dickinson, P. J., and Bankiewicz, K. S., 2008.
    Image-guided convection-enhanced delivery platform in the treatment of neurological diseases. Neurotherapeutics 5, 123-127
  6. Varenika V, Dickinson P, Bringas J, LeCouteur R, Higgins R, Park J, Fiandaca MS, Berger M, Sampson J and Bankiewicz KS., 2008.
    Real-Time Imaging of CED in the Brain Permits Detection of Infusate Leakage. Journal of Neurosurgery.
  7. Hadaczek, P., J. Forsayeth, et al. (2008).
    "Transduction of non-human primate brain with adeno-associated virus serotype 1: vector trafficking and immune response." Hum Gene Ther.
  8. Herzog, C. D., B. Dass, et al. (2008).
    "Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum." Mol Ther 16(10): 1737-44.
  9. Johnston, L. C., X. Su, et al. (2008).
    "Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease." Mol Ther 16(8): 1392-9.
  10. Kells, A. P., P. Hadaczek, et al. (2009).
    "Efficient gene therapy-based method for the delivery of therapeutics to primate cortex." Proc Natl Acad Sci U S A.
  11. Kikuchi, T., R. Saito, et al. (2008).
    "Convection-enhanced delivery of polyethylene glycol-coated liposomal doxorubicin: characterization and efficacy in rat intracranial glioma models." J Neurosurg 109(5): 867-73.
  12. Krauze, M. T., S. R. Vandenberg, et al. (2008).
    "Safety of real-time convection-enhanced delivery of liposomes to primate brain: a long-term retrospective." Exp Neurol 210(2): 638-44.
  13. Richardson, R. M., P. S. Larson, et al. (2008).
    "Gene and cell delivery to the degenerated striatum: status of preclinical efforts in primate models." Neurosurgery 63(4): 629-442; dicussion 642-4.
  14. Varenika, V., P. Dickinson, et al. (2008).
    "Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery." J Neurosurg 109(5): 874-80.

2007

  1. Krauze, M. T., Noble, C. O., Kawaguchi, T., Drummond, D., Kirpotin, D. B., Yamashita, Y., Kullberg, E., Forsayeth, J., Park, J. W., and Bankiewicz, K. S., 2007.
    Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts. Neuro Oncol 9, 393-403
  2. Yamashita, Y., Krauze, M. T., Kawaguchi, T., Noble, C. O., Drummond, D. C., Park, J. W., and Bankiewicz, K. S., 2007.
    Convection-enhanced delivery of a topoisomerase I inhibitor (nanoliposomal topotecan) and a topoisomerase II inhibitor (pegylated liposomal doxorubicin) in intracranial brain tumor xenografts. Neuro Oncol 9, 20-28
  3. Krauze, M. T., Vandenberg, S. R., Yamashita, Y., Saito, R., Forsayeth, J., Noble, C., Park, J., and Bankiewicz, K. S., 2007.
    Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective. Exp Neurol

2006

  1. Hadaczek, P., Yamashita, Y., Mirek, H., Tamas, L., Bohn, M. C., Noble, C., Park, J. W., and Bankiewicz, K., 2006.
    The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther 14, 69-78
  2. Hadaczek, P., Kohutnicka, M., Krauze, M. T., Bringas, J., Pivirotto, P., Cunningham, J., and Bankiewicz, K., 2006.
    Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain. Hum Gene Ther 17, 291-302
  3. Noble, C. O., Krauze, M. T., Drummond, D. C., Yamashita, Y., Saito, R., Berger, M. S., Kirpotin, D. B., Bankiewicz, K. S., and Park, J. W., 2006.
    Novel nanoliposomal CPT-11 infused by convection-enhanced delivery in intracranial tumors: pharmacology and efficacy. Cancer Res 66, 2801-2806
  4. Saito, R., Krauze, M. T., Noble, C. O., Drummond, D. C., Kirpotin, D. B., Berger, M. S., Park, J. W., and Bankiewicz, K. S., 2006.
    Convection-enhanced delivery of Ls-TPT enables an effective, continuous, low-dose chemotherapy against malignant glioma xenograft model. Neuro Oncol 8, 205-214
  5. Sampson, J. H., Akabani, G., Friedman, A. H., Bigner, D., Kunwar, S., Berger, M. S., and Bankiewicz, K. S., 2006.
    Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies. Neurosurg Focus 20, E14
  6. Krauze, M. T., Forsayeth, J., Park, J. W., and Bankiewicz, K. S., 2006.
    Real-time imaging and quantification of brain delivery of liposomes. Pharm Res 23, 2493-2504
  7. Saito, R., Krauze, M. T., Noble, C. O., Tamas, M., Drummond, D. C., Kirpotin, D. B., Berger, M. S., Park, J. W., and Bankiewicz, K. S., 2006.
    Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: implications for local drug delivery. J Neurosci Methods 154, 225-232
  8. Bankiewicz, K. S., Daadi, M., Pivirotto, P., Bringas, J., Sanftner, L., Cunningham, J., Forsayeth, J. R., and Eberling, J. L., 2006
    Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys. Exp Neurol 197, 363-372
  9. Bankiewicz, K. S., Forsayeth, J., Eberling, J. L., Sanchez-Pernaute, R., Pivirotto, P., Bringas, J., Herscovitch, P., Carson, R. E., Eckelman, W., Reutter, B., and Cunningham, J., 2006.
    Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC. Mol Ther 14, 564-570
  10. Forsayeth, J. R., Eberling, J. L., Sanftner, L. M., Zhen, Z., Pivirotto, P., Bringas, J., Cunningham, J., and Bankiewicz, K. S., 2006.
    A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys. Mol Ther 14, 571-577

2005

  1. Hadaczek, P., Mirek, H., Berger, M. S., and Bankiewicz, K., 2005.
    Limited efficacy of gene transfer in herpes simplex virus-thymidine kinase/ganciclovir gene therapy for brain tumors. J Neurosurg 102, 328-335
  2. Krauze, M. T., McKnight, T. R., Yamashita, Y., Bringas, J., Noble, C. O., Saito, R., Geletneky, K., Forsayeth, J., Berger, M. S., Jackson, P., Park, J. W., and Bankiewicz, K. S., 2005.
    Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging. Brain Res Brain Res Protoc 16, 20-26
  3. Krauze, M. T., Saito, R., Noble, C., Bringas, J., Forsayeth, J., McKnight, T. R., Park, J., and Bankiewicz, K. S., 2005.
    Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen. Exp Neurol 196, 104-111
  4. Krauze, M. T., Saito, R., Noble, C., Tamas, M., Bringas, J., Park, J. W., Berger, M. S., and Bankiewicz, K., 2005.
    Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents. J Neurosurg 103, 923-929
  5. Saito, R., Krauze, M. T., Bringas, J. R., Noble, C., McKnight, T. R., Jackson, P., Wendland, M. F., Mamot, C., Drummond, D. C., Kirpotin, D. B., Hong, K., Berger, M. S., Park, J. W., and Bankiewicz, K. S., 2005.
    Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp Neurol 196, 381-389
  6. Sanftner, L. M., Sommer, J. M., Suzuki, B. M., Smith, P. H., Vijay, S., Vargas, J. A., Forsayeth, J. R., Cunningham, J., Bankiewicz, K. S., Kao, H., Bernal, J., Pierce, G. F., and Johnson, K. W., 2005.
    AAV2-mediated gene delivery to monkey putamen: evaluation of an infusion device and delivery parameters. Exp Neurol 194, 476-483

2004

  1. Hadaczek, P., Mirek, H., Bringas, J., Cunningham, J., and Bankiewicz, K., 2004.
    Basic fibroblast growth factor enhances transduction, distribution, and axonal transport of adeno-associated virus type 2 vector in rat brain. Hum Gene Ther 15, 469-479
  2. Saito, R., Bringas, J., Mirek, H., Berger, M. S., and Bankiewicz, K. S., 2004.
    Invasive phenotype observed in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant sublines of 9L rat glioma cells: a tumor model mimicking a recurrent malignant glioma. J Neurosurg 101, 826-831
  3. Saito, R., Bringas, J. R., Panner, A., Tamas, M., Pieper, R. O., Berger, M. S., and Bankiewicz, K. S., 2004.
    Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial glioblastoma xenograft model. Cancer Res 64, 6858-6862
  4. Mamot, C., Nguyen, J. B., Pourdehnad, M., Hadaczek, P., Saito, R., Bringas, J. R., Drummond, D. C., Hong, K., Kirpotin, D. B., McKnight, T., Berger, M. S., Park, J. W., and Bankiewicz, K. S., 2004.
    Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol 68, 1-9
  5. Saito, R., Bringas, J. R., McKnight, T. R., Wendland, M. F., Mamot, C., Drummond, D. C., Kirpotin, D. B., Park, J. W., Berger, M. S., and Bankiewicz, K. S., 2004.
    Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res 64, 2572-2579

2003

  1. D'Costa, J., Harvey-White, J., Qasba, P., Limaye, A., Kaneski, C. R., Davis-Warren, A., Brady, R. O., Bankiewicz, K. S., Major, E. O., and Arya, S. K., 2003.
    HIV-2 derived lentiviral vectors: gene transfer in Parkinson's and Fabry disease models in vitro. J Med Virol 71, 173-182
  2. Eberling, J. L., Cunningham, J., Pivirotto, P., Bringas, J., Daadi, M. M., and Bankiewicz, K. S., 2003.
    In vivo PET imaging of gene expression in Parkinsonian monkeys. Mol Ther 8, 873-875
  3. Emborg, M. E., Tetrud, J. W., Moirano, J., McLaughlin, W. W., and Bankiewicz, K. S., 2003.
    Rest tremor in rhesus monkeys with MPTP-induced parkinsonism. Front Biosci 8, a148-154
  4. Oiwa, Y., Eberling, J. L., Nagy, D., Pivirotto, P., Emborg, M. E., and Bankiewicz, K. S., 2003.
    Overlesioned hemiparkinsonian non human primate model: correlation between clinical, neurochemical and histochemical changes. Front Biosci 8, a155-166
  5. Oiwa, Y., Sanchez-Pernaute, R., Harvey-White, J., and Bankiewicz, K. S., 2003.
    Progressive and extensive dopaminergic degeneration induced by convection-enhanced delivery of 6-hydroxydopamine into the rat striatum: a novel rodent model of Parkinson disease. J Neurosurg 98, 136-144
  6. Goldstein, D. S., Li, S. T., Holmes, C., and Bankiewicz, K., 2003.
    Sympathetic innervation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease. J Pharmacol Exp Ther 306, 855-860

2002

  1. Kim, J. H., Auerbach, J. M., Rodriguez-Gomez, J. A., Velasco, I., Gavin, D., Lumelsky, N., Lee, S. H., Nguyen, J., Sanchez-Pernaute, R., Bankiewicz, K., and McKay, R., 2002.
    Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 418, 50-56

2001

  1. Hamilton, J. F., Morrison, P. F., Chen, M. Y., Harvey-White, J., Pernaute, R. S., Phillips, H., Oldfield, E., and Bankiewicz, K. S., 2001.
    Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin. Exp Neurol 168, 155-161
  2. Nguyen, J. B., Sanchez-Pernaute, R., Cunningham, J., and Bankiewicz, K. S., 2001.
    Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brain. Neuroreport 12, 1961-1964
  3. Sanchez-Pernaute, R., Harvey-White, J., Cunningham, J., and Bankiewicz, K. S., 2001.
    Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats. Mol Ther 4, 324-330
  4. Sanchez-Pernaute, R., Studer, L., Bankiewicz, K. S., Major, E. O., and McKay, R. D., 2001.
    In vitro generation and transplantation of precursor-derived human dopamine neurons. J Neurosci Res 65, 284-288

2000

  1. Bankiewicz, K. S., Bringas, J., Pivirotto, P., Kutzscher, E., Nagy, D., and Emborg, M. E., 2000.
    Technique for bilateral intracranial implantation of cells in monkeys using an automated delivery system. Cell Transplant 9, 595-607
  2. Cunningham, J., Oiwa, Y., Nagy, D., Podsakoff, G., Colosi, P., and Bankiewicz, K. S., 2000.
    Distribution of AAV-TK following intracranial convection-enhanced delivery into rats. Cell Transplant 9, 585-594
  3. Qureshi, N. H., Bankiewicz, K. S., Louis, D. N., Hochberg, F. H., Chiocca, E. A., and Harsh, G. R. t., 2000.
    Multicolumn infusion of gene therapy cells into human brain tumors: technical report. Neurosurgery 46, 663-668; discussion 668-669
  4. Bankiewicz, K. S., Eberling, J. L., Kohutnicka, M., Jagust, W., Pivirotto, P., Bringas, J., Cunningham, J., Budinger, T. F., and Harvey-White, J., 2000.
    Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach. Exp Neurol 164, 2-14
  5. Eberling, J. L., Pivirotto, P., Bringas, J., and Bankiewicz, K. S., 2000.
    Tremor is associated with PET measures of nigrostriatal dopamine function in MPTP-lesioned monkeys. Exp Neurol 165, 342-346